Review
Chemistry, Multidisciplinary
George Karageorgis, Daniel J. Foley, Luca Laraia, Susanne Brakmann, Herbert Waldmann
Summary: PNPs are compounds formed by combining NP fragments in unique ways, inheriting important biological characteristics of NPs while exhibiting unprecedented bioactivity. The importance of design principles, synthesis, and biological research on PNP scaffolds is emphasized. PNPs are considered as a human-driven branch of the evolution of natural product structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Davide Mendes, Sofia Branco, Maria Rosa Paiva, Stefan Schutz, Eduardo P. Mateus, Marco Gomes da Silva
Summary: Multidimensional gas chromatography is a powerful analytical tool that allows for precise identification of compounds in complex matrices. The research on host selection behavior of the eucalyptus weevil discovered an attractive pheromone blend for both male and female weevils. By combining different techniques, relevant compounds were successfully selected and identified.
Article
Chemistry, Multidisciplinary
Dongseok Jang, Minchul Choi, Jinglong Chen, Chulbom Lee
Summary: The first enantioselective total synthesis of (+)-garsubellin A was reported, showcasing high synthetic efficiency and simplicity. The synthesis relied on stereoselective construction of a cyclohexanone framework and double conjugate addition to promote aldol cyclization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biodiversity Conservation
Reza Erfanzadeh, Ali Ansari, Mohammad Jafari, Peter Torok
Summary: The aim of this study was to assess the effects of burning savin shrubs on the soil seed bank, microbial respiration, and organic matter. The immediate effects of burning were found to be significantly negative, particularly in terms of soil seed bank density, microbial respiration magnitude, and organic matter amount in the top 0-5 cm of soil. Additionally, savin burning caused soil alkalization and decreased soil quality, potentially hindering vegetation recovery in the long term.
GLOBAL ECOLOGY AND CONSERVATION
(2023)
Article
Plant Sciences
Yan Li, Christian Zidorn
Summary: The present review provides an overview of research on the seasonal variation of natural products in herbs growing in or grown in Europe. The study separates plants from Mediterranean, temperate, and cold climate zones due to differences in weather patterns. The review aims to summarize recent literature, identify seasonal trends, and discuss possible explanations. The investigations mainly focus on aerial parts and leaves, with some publications also examining flowers and roots. Essential oil composition and phenolics are the most frequently studied compound classes.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Yuan-Fei Zhou, Bing-Chao Yan, Qian Yang, Xin-Yan Long, Dan-Qi Zhang, Rong-Hua Luo, Han-Yu Wang, Han-Dong Sun, Xiao-Song Xue, Yong-Tang Zheng, Pema-Tenzin Puno
Summary: A pharmacophore-oriented semisynthesis approach was used to discover anti-SARS-CoV-2 agents by modifying (-)-maoelactone A and oridonin. The WRLC reaction was developed to construct the maoelactone-type scaffold, and further mechanistic study revealed the mechanisms of Wolff rearrangement and lactonization. The creation of a novel family by combining the maoelactone-type scaffold and the pharmacophore of oridonin resulted in a derivative with potent anti-SARS-CoV-2 activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Zachary Schwartz, Chelsea Valiton, Myles Lovasz, Andrew G. Roberts
Summary: Ammonium ylide based [2,3]-sigmatropic and [1,2]-Stevens rearrangements are used to convert tertiary amines into rearranged and functionalized intermediates for the synthesis of polycyclic natural products. This review summarizes recent applications of these rearrangement reactions in formal and total synthesis and discusses innovative improvements to these transformations.
SYNTHESIS-STUTTGART
(2023)
Review
Pharmacology & Pharmacy
Mihael Cristin Ichim, Anthony Booker
Summary: Chemical methods are crucial for identifying the authenticity of botanical products, with the majority being authentic but a significant proportion found to be adulterated. Varying levels of adulteration were reported across different countries, with the United Kingdom, Italy, the United States, and China reporting different percentages of adulterated products.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Meri Yulvianti, Christian Zidorn
Summary: Cyanogenic glycosides are important and widespread natural products found in more than 2500 plant species with 112 known compounds so far. They exhibit variations in both the sugar moiety and aglycone moiety, with glucose being the predominant sugar base and four different basic classes of aglycones identified.
Article
Chemistry, Organic
Mikhail Elyashberg, Ivan M. Novitskiy, Roderick W. Bates, Andrei G. Kutateladze, Craig M. Williams
Summary: In the pursuit of understanding biodiversity chemistry, the discovery of natural products is crucial. However, determining their chemical structure is not easy due to their inherent complexity. This study presents a combination of methods, including chemical intuition, synthesis, CASE, and DU8+ spectrum prediction, to accurately reassign the structures of counterfactual natural products.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Patil Shivprasad Suresh, Surekha Kumari, Dinkar Sahal, Upendra Sharma
Summary: Living organisms have developed diverse natural products through evolution, which play important roles in defense, growth regulation, metabolism, and other functions. These natural products are influenced by the ecological niche of organisms and contribute to the co-evolution and ecological relationships among different life forms. They also provide potential new therapeutic targets and drugs for humans.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Raphael E. Wildermuth, Christian Steinborn, David M. Barber, Kim S. Muehlfenzl, Mario Kendlbacher, Peter Mayer, Klaus Wurst, Thomas Magauer
Summary: This study provides a thorough account of the evolution of the first total synthesis of (+)-cornexistin. Utilizing a chiral-pool strategy, the challenges of low yields and difficulties in stereocenter installation were successfully addressed. Key steps included an intermolecular NHK coupling, a syn-Evans-aldol reaction, an intramolecular allylic alkylation, and a stepwise hydrolysis of a beta-keto nitrile.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Lorenzo Serusi, Federico Cuccu, Francesco Secci, David J. Aitken, Angelo Frongia
Summary: A novel Bronsted acid promoted condensation reaction has been developed for the synthesis of diverse tryptamine derivatives in moderate to good yields, involving an alpha-iminol rearrangement, ring expansion, ring closure, and a depart-and-return rearrangement process.
SYNTHESIS-STUTTGART
(2021)
Review
Biochemistry & Molecular Biology
Naoki Mori, Koji Noge
Summary: Chemical ecology is an interdisciplinary field studying biochemicals that mediate organism behavior and regulate physiological changes affecting interactions within or between species. Collaboration between chemists and biologists leads to significant advances in understanding organism survival strategies and developing targeted technologies for controlling pests in various fields sustainably.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Jian Zou, Sheng-Peng Wang, Yi-Tao Wang, Jian-Bo Wan
Summary: The NLRP3 inflammasome plays a crucial role in chemical-induced liver injury, but natural products have shown therapeutic potential in CILI by modulating inflammasome pathways.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Robyn E. Shaw, Sam C. Banks, Rod Peakall
Article
Biodiversity Conservation
D. Stojanovic, G. Olah, M. Webb, R. Peakall, R. Heinsohn
ANIMAL CONSERVATION
(2018)
Article
Plant Sciences
Ryan D. Phillips, Rod Peakall
AUSTRALIAN JOURNAL OF BOTANY
(2018)
Article
Chemistry, Medicinal
Bjorn Bohman, Ryan D. Phillips, Gavin R. Flematti, Rod Peakall
Article
Chemistry, Organic
Meng Yao Zhang, Russell A. Barrow
JOURNAL OF ORGANIC CHEMISTRY
(2018)
Article
Plant Sciences
Weihua Chen, Hooman Salari, Matthew C. Taylor, Ricarda Jost, Oliver Berkowitz, Russell Barrow, Deyun Qiu, Remi Branco, Josette Masle
Article
Plant Sciences
Weihua Chen, Matthew C. Taylor, Russell A. Barrow, Mikael Croyal, Josette Masle
Article
Veterinary Sciences
Y. Hood, J. Sadler, J. Poldy, C. S. Starkey, A. P. Robinson
PREVENTIVE VETERINARY MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Saliya Gurusinghe, Tabin L. Brooks, Russell A. Barrow, Xiaocheng Zhu, Agasthya Thotagamuwa, Paul G. Dennis, Vadakattu V. S. R. Gupta, Thiru Vanniasinkam, Leslie A. Weston
Article
Microbiology
Mariano Jordi Muria-Gonzalez, Yeannie Yeng, Susan Breen, Oliver Mead, Chen Wang, Yi-Heng Chooi, Russell A. Barrow, Peter S. Solomon
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sajid Latif, Paul A. Weston, Russell A. Barrow, Saliya Gurusinghe, John W. Piltz, Leslie A. Weston
Article
Biochemistry & Molecular Biology
Nisansala N. Perera, Paul A. Weston, Russell A. Barrow, Leslie A. Weston, Geoff M. Gurr
Summary: Volatile cues play a significant role in the location and discrimination of food resources by insects. This study investigated the behavioral responses and volatile organic compounds (VOCs) of the dung beetle Bubas bison to different types of animal dung. The results showed that horse dung attracted B. bison more strongly than cattle dung, and the diet of the horses also influenced their preference. Furthermore, the abundance and composition of VOCs varied with dung type and livestock diet.
Article
Biochemical Research Methods
Lachlan Dow, Russell A. Barrow, Rosemary G. White, Ulrike Mathesius
Summary: This study presents a novel cell-targeted method of activating a caged cytokinin in single plant cells. The technique combines multiphoton confocal microscopy and caged cytokinin treatment to achieve cell type-specific uncaging. The results demonstrate the potential of this method in elucidating various processes in plant development.
Article
Pathology
Jacqueline Poldy, Stefania Gelendi, Daria Starybrat, Jorge Del-Pozo
Summary: Phaeochromocytomas are rare tumours of the adrenal medulla that can cause various symptoms. Excessive catecholamine secretion from these tumours can lead to weakness, increased heart rate, and rapid breathing. Invasive phaeochromocytomas can also cause occlusion of the caudal vena cava, resulting in systemic cardiovascular compromise. This article reports on a dog with an invasive unilateral phaeochromocytoma that showed myocardial damage consistent with catecholamine-induced cardiomyopathy, as well as leukocytoclastic vasculitis in small vessels in multiple tissues. This is the first documented association between phaeochromocytoma and leukocytoclastic vasculitis in a non-human species.
JOURNAL OF COMPARATIVE PATHOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Jacqueline Poldy