期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2012, 期 19, 页码 3561-3565出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201200261
关键词
Scandium; Pyranose; Alkoxycarboxylation; Esterification; Chemoselectivity
A highly selective method for the alkoxycarboxylation and acylation of primary alcohols of pyranose derivatives is described. The reaction is high yielding and proceeds under mild conditions with 0.151 mol-% Sc(OTf)3 used in combination with anhydrides or pyrocarbonates at 4050 degrees C. Selectivities observed for alkoxycarboxylation of unprotected pyranose derivatives are > 95?%, and this constitutes a significant advantage over existing methods. Mechanistic implications, including the role of steric demand and metalheteroatom coordination are also discussed.
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