期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2011, 期 18, 页码 3283-3292出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100371
关键词
Boron; Cobalt; Cross-coupling; Cycloaddition; Rhodium
资金
- Universite Pierre et Marie Curie (UPMC)
- Universite Paris-Sud (UPS)
- Ministere de la Recherche
- Centre National de la Recherche Scientifique (CNRS)
- Institut Universitaire de France (IUF)
- National Science Foundation (NSF) [CHE 0907800]
- Direct For Mathematical & Physical Scien [0907800] Funding Source: National Science Foundation
- Division Of Chemistry [0907800] Funding Source: National Science Foundation
Oligoaryls were prepared through transition-metal-catalyzed [2+2+2] cycloadditions of borylated alkynes, followed by Suzuki cross-couplings with aryl halides. Ethynylboryl pinacolate took part in cobalt-catalyzed [2+2+2] cycloadditions of all types investigated (i.e., all-intermolecular cyclotrimerization, diyne-yne cocyclization, and all-intramolecular triyne cyclo-isomerization). The resulting platforms gave rise to linear and angular ter- and quateraryls after Pd-catalyzed cross-coupling. In addition, the first [2+2+2] cycloadditions involving alkynyl naphthaloboramides were developed. These derivatives could be cocyclized with diynes in the presence of a rhodium complex as catalyst. Because the boramide group is inactive under Suzuki coupling conditions, but can be readily deprotected to afford an active one, an iterative functionalization of a boronate-/boramide-substituted benzene could be achieved.
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