Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

(2011) Morgane Bomsel et al.   IMMUNITY

Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen-Friedenreich Antigen and a Fluorine-Substituted Analogue

(2010) Anja Hoffmann-Röder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2

(2010) Anton Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria

(2010) Marco Tamborrini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Defining Criteria for Oligomannose Immunogens for HIV Using Icosahedral Virus Capsid Scaffolds

(2010) Rena D. Astronomo et al.   CHEMISTRY & BIOLOGY

Chemoenzymatic Synthesis of a Glycolipid Library and Elucidation of the Antigenic Epitope for Construction of a Vaccine Against Lyme Disease

(2010) Gunthard Stübs et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applications of synthetic carbohydrates to chemical biology

(2010) Bernd Lepenies et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Preparation, characterization and immunogenicity of HIV-1 related high-mannose oligosaccharides-CRM197 glycoconjugates

(2010) Anna Kabanova et al.   GLYCOCONJUGATE JOURNAL

Synthesis of a Single-Moleculel-Rhamnose-Containing Three-Component Vaccine and Evaluation of Antigenicity in the Presence of Anti-l-Rhamnose Antibodies

(2010) Sourav Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical approaches for the study of the mycobacterial glycolipids phosphatidylinositol mannosides, lipomannan and lipoarabinomannan

(2010) Benjamin Cao et al.   NATURAL PRODUCT REPORTS

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

Facile glycosylation strategy with two-stage activation of allyl glycosyl donors. Application to concise synthesis of Shigella flexneri serotype Y O-antigen

(2010) Yun Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

(2010) K. J. Doores et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine

(2009) Govind Ragupathi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Synthetic studies on the carbohydrate moiety of the antigen from the parasite Echinococcusmultilocularis

(2009) Akihiko Koizumi et al.   CARBOHYDRATE RESEARCH

Synthesis of monodeoxy and mono-O-methyl congeners of methyl β-d-mannopyranosyl-(1→2)-β-d-mannopyranoside for epitope mapping of anti-Candida albicans antibodies

(2009) Corwin M. Nycholat et al.   CARBOHYDRATE RESEARCH

Synthesis of trisaccharides containing internal galactofuranose O-linked in Trypanosoma cruzi mucins

(2009) Verónica M. Mendoza et al.   CARBOHYDRATE RESEARCH

Synthesis, Conjugation, and Immunological Evaluation of the Serogroup 6 Pneumococcal Oligosaccharides

(2009) Archana R. Parameswar et al.   CHEMBIOCHEM

Increasing the Antigenicity of Synthetic Tumor-Associated Carbohydrate Antigens by Targeting Toll-Like Receptors

(2009) Sampat Ingale et al.   CHEMBIOCHEM

β-glucan recognition by the innate immune system

(2009) Helen S. Goodridge et al.   IMMUNOLOGICAL REVIEWS

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Efficient Synthesis of Six Tri- to Hexasaccharide Fragments ofShigella flexneriSerotypes 3a and/or X O-Antigen, Including a Study on Acceptors ContainingN-Trichloroacetylglucosamine versusN-Acetylglucosamine

(2009) Julien Boutet et al.   JOURNAL OF ORGANIC CHEMISTRY

A Practical Total Synthesis of Globo-H for Use in Anticancer Vaccines

(2009) Insik Jeon et al.   JOURNAL OF ORGANIC CHEMISTRY

From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Model for the Presentation of Tumor-Associated Antigens and the Quest for an Anticancer Vaccine: A Solution to the Synthesis Challenge via Ring-Closing Metathesis

(2009) Insik Jeon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biologics through Chemistry: Total Synthesis of a Proposed Dual-Acting Vaccine Targeting Ovarian Cancer by Orchestration of Oligosaccharide and Polypeptide Domains

(2009) Jianglong Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates

(2009) Ravindra A. De Silva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

(2009) Johannes F. Scheid et al.   NATURE

Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

(2009) Thomas J. Boltje et al.   Nature Chemistry

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthesis, molecular dynamics simulations, and biology of a carba-analogue of the trisaccharide repeating unit of Streptococcus pneumoniae 19F capsular polysaccharide

(2009) Laura Legnani et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides

(2009) S. Gallorini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycans on influenza hemagglutinin affect receptor binding and immune response

(2009) C.-C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

‘Biologic’ level structures through chemistry: a total synthesis of a unimolecular pentavalent MUCI glycopeptide construct

(2009) Dongjoo Lee et al.   TETRAHEDRON LETTERS

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

The common Cryptococcus neoformans glucuronoxylomannan M2 motif elicits non-protective antibodies

(2009) Antonio Nakouzi et al.   VACCINE

Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody

(2009) Ussama M. Abdel-Motal et al.   VACCINE

Multivalent, Saccharide-Functionalized Gold Nanoparticles as Fully Synthetic Analogs of Type ANeisseria meningitidisAntigens

(2008) Flavio Manea et al.   ADVANCED MATERIALS

Glycoconjugates As Vaccines for Cancer Immunotherapy: Clinical Trials and Future Directions

(2008) Alssandra Franco   Anti-Cancer Agents in Medicinal Chemistry

Calix[4]arene Decorated with Four Tn Antigen Glycomimetic Units and P3CS Immunoadjuvant: Synthesis, Characterization, and Anticancer Immunological Evaluation

(2008) Corrada Geraci et al.   BIOCONJUGATE CHEMISTRY

Antitumor activity of a self-adjuvanting glyco-lipopeptide vaccine bearing B cell, CD4+ and CD8+ T cell epitopes

(2008) Ilham Bettahi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Automated carbohydrate synthesis as platform to address fundamental aspects of glycobiology—current status and future challenges

(2008) Peter H. Seeberger   CARBOHYDRATE RESEARCH

Synthesis of spacer-containing analogs of serogroup 6 pneumococcal oligosaccharides

(2008) Archana R. Parameswar et al.   CARBOHYDRATE RESEARCH

Synthesis of an anthrose derivative and production of polyclonal antibodies for the detection of anthrax spores

(2008) Sandrine G.Y. Dhénin et al.   CARBOHYDRATE RESEARCH

Synthesis of a heptasaccharide fragment of the mannan from Candida guilliermondii cell wall and its conjugate with BSA

(2008) Alexander A. Karelin et al.   CARBOHYDRATE RESEARCH

Chemical Synthesis and Immunological Properties of Oligosaccharides Derived from the Vegetative Cell Wall ofBacillus anthracis

(2008) Mahalakshmi Vasan et al.   CHEMBIOCHEM

A Novel Linker Methodology for the Synthesis of Tailored Conjugate Vaccines Composed of Complex Carbohydrate Antigens and Specific TH‐Cell Peptide Epitopes

(2008) Sebastian Dziadek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and Immunochemical characterization ofS-linked Glycoconjugate Vaccines againstCandida albicans

(2008) Xiangyang Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Towards a Self-Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

(2008) Olivier Renaudet et al.   ChemMedChem

Recent Trends in Glycodendrimer Syntheses and Applications

(2008) Yoann Chabre et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recent Developments in Synthetic Oligosaccharide-Based Bacterial Vaccines

(2008) Vince Pozsgay   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis of Two Tetra- and Four Pentasaccharide Fragments ofShigella flexneriSerotypes 3a and X O-Antigens from a Common Tetrasaccharide Intermediate

(2008) Julien Boutet et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Identification of the Smallest Structure Capable of Evoking Opsonophagocytic Antibodies against Streptococcus pneumoniae Type 14

(2008) D. Safari et al.   INFECTION AND IMMUNITY

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc

(2008) Tongzhong Ju et al.   JOURNAL OF CELL BIOLOGY

Efficient Chemical Synthesis of a Dodecasaccharidyl Lipomannan Component of Mycobacterial Lipoarabinomannan†

(2008) Bert Fraser-Reid et al.   JOURNAL OF ORGANIC CHEMISTRY

De Novo Asymmetric Synthesis of Anthrax Tetrasaccharide and Related Tetrasaccharide

(2008) Haibing Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Differential High-Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans Is Dependent upon Primary Structure and Is Influenced by Polymer Chain Length and Side-Chain Branching

(2008) E. L. Adams et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chemical Synthesis of All Phosphatidylinositol Mannoside (PIM) Glycans fromMycobacterium tuberculosis

(2008) Siwarutt Boonyarattanakalin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expeditious Synthesis of Water-Soluble, Monolayer-Protected Gold Nanoparticles of Controlled Size and Monolayer Composition

(2008) Flavio Manea et al.   LANGMUIR

Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?

(2008) Armelle Phalipon et al.   MICROBES AND INFECTION

Identification of O-glycosylated decapeptides within the MUC1 repeat domain as potential MHC class I (A2) binding epitopes

(2008) Tanja Ninkovic et al.   MOLECULAR IMMUNOLOGY

Synthetic GPI array to study antitoxic malaria response

(2008) Faustin Kamena et al.   Nature Chemical Biology

Immunity to malaria: more questions than answers

(2008) Jean Langhorne et al.   NATURE IMMUNOLOGY

Synthesis of a Hexasaccharide Repeating Unit fromBacillus anthracisVegetative Cell Walls

(2008) Matthias A. Oberli et al.   ORGANIC LETTERS

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN

(2008) S.-K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic glycopeptide vaccines combining  -mannan and peptide epitopes induce protection against candidiasis

(2008) H. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody

(2008) B. Vulliez-Le Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies

(2008) A. K. Kashyap et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of vaccines on pneumonia: Key lessons from Haemophilus influenzae type b conjugate vaccines

(2008) Bradford D. Gessner et al.   VACCINE

Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin

(2008) Manabu Igarashi et al.   VIROLOGY

The Galα1,3Galβ1,4GlcNAc-R (α-Gal) epitope: A carbohydrate of unique evolution and clinical relevance

(2007) Bruce A. Macher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Variant synthetic pathway to glucuronic acid-containing di- and trisaccharide thioglycoside building blocks for continued synthesis of Cryptococcus neoformans capsular polysaccharide structures

(2007) Jan Vesely et al.   CARBOHYDRATE RESEARCH

Automated oligosaccharide synthesis

(2007) Peter H. Seeberger   CHEMICAL SOCIETY REVIEWS

Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis

(2007) James C. Sacchettini et al.   NATURE REVIEWS MICROBIOLOGY

Immune responses to polysaccharides: Lessons from humans and mice

(2007) África González-Fernández et al.   VACCINE

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

(2007) James W. Huleatt et al.   VACCINE