☆ 4.5 Article

Enantioselective Ring Opening Reaction of meso-Epoxides with Aromatic and Aliphatic Amines Catalyzed by Magnesium Complexes of BINOL Derivatives

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2010)

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

卷 2010, 期 35, 页码 6722-6726

出版社

WILEY-V C H VERLAG GMBH

DOI: 10.1002/ejoc.201001222

关键词

Asymmetric catalysis; Epoxides; Amino alcohols; Amines; Magnesium

类别

Chemistry, Organic

资金

National Natural Science Foundation of China [20923005, 20821002]
Chinese Academy of Sciences
Major Basic Research Development Program of China [2010CB833300]
Science and Technology Commission of Shanghai Municipality

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Protocol

Reagent

摘要

Catalyzed by the Mg complexes of BINOL derivatives, the enantioselective ring opening reaction of various meso-epoxides proceeded smoothly with either aromatic or aliphatic amines as the nucleophiles to afford the corresponding chiral beta-amino alcohols in moderate-to-high yields with good to excellent enantioselectivities.

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