☆ 4.5 Article

A Tandem Michael-SN2-Mediated General Route to Six-Membered Heterocycles and Carbocycles

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2010)

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

卷 2010, 期 35, 页码 6810-6819

出版社

WILEY-V C H VERLAG GMBH

DOI: 10.1002/ejoc.201000941

关键词

Carbocycles; Heterocycles; Sulfones; Desulfonylation; Michael addition; Nucleophilic substitution

类别

Chemistry, Organic

资金

Department of Science and Technology (DST), New Delhi
Council for Scientific and Industrial Research, New Delhi

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摘要

A powerful, flexible, and stereoselective general strategy for the construction of chirally pure six-membered heterocycles and carbocycles by utilizing a tandem Michael-S(N)2 sequence is described. The strategy avoids the tedious synthesis of separate starting materials prior to cyclization. The expedient and general strategy, which is virtually untapped until now, will enrich the arsenal of synthetic chemists for the preparation of cyclic compounds.

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