4.5 Article

Randomized Comparative Trial of a Social Cognitive Skills Group for Children With Autism Spectrum Disorder

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.jaac.2014.12.005

关键词

social skills groups; autism; social cognition; cognitive behavioral intervention; social communication

资金

  1. Autism Speaks
  2. National Institute of Mental Health (NIMH) [R21MH089236-01]
  3. Brain and Behavior Research Foundation
  4. Seaver Foundation

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Objective: This study evaluated the efficacy of a targeted social skills training group in school-aged children with autism spectrum disorder (ASD). The intervention, Seaver-NETT (Nonverbal communication, Emotion recognition, and Theory of mind Training), is a 12-session cognitive-behavioral intervention (CBI) for verbal, school-aged children targeting ASD-specific social behavioral impairments. Method: Sixty-nine children with ASD, 8 to 11 years of age, with verbal IQs greater than 70, participated in a randomized comparative trial to examine the efficacy of NETT relative to a facilitated play group. Treatment outcomes included caregiver reports of social behavior and neuropsychological assessments of social cognition conducted by blinded raters. Outcomes were collected at baseline, endpoint, and 3 months posttreatment. Results: Significant improvements were found on social behavior outcomes such as nonverbal communication, empathic responding, and social relations in the NETT condition relative to the active control at endpoint. Verbal IQ moderated the interaction effect on social behavior, with higher verbal IQ associated with improvements in the CBI condition. No significant improvements were found on social cognitive outcomes. No significant group differences were found at 3-month follow-up conducted with approximately half the sample (n = 34). Conclusion: These data indicate that targeted CBI social skills groups such as NETT improve social communication deficits in verbal, school-aged children with ASD. The moderating effects of high verbal IQ suggest a need to consider participant and treatment characteristics associated with outcomes in future studies.

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Article Clinical Neurology

CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD

Lisa Pavinato, Andrea Delle Vedove, Diana Carli, Marta Ferrero, Silvia Carestiato, Jennifer L. Howe, Emanuele Agolini, Domenico A. Coviello, Ingrid van de Laar, Ping Yee Billie Au, Eleonora Di Gregorio, Alessandra Fabbiani, Susanna Croci, Maria Antonietta Mencarelli, Lucia P. Bruno, Alessandra Renieri, Danai Veltra, Christalena Sofocleous, Laurence Faivre, Benoit Mazel, Hana Safraou, Anne-Sophie Denomme-Pichon, Marjon A. van Slegtenhorst, Noor Giesbertz, Richard H. van Jaarsveld, Anna Childers, R. Curtis Rogers, Antonio Novelli, Silvia De Rubeis, Joseph D. Buxbaum, Stephen W. Scherer, Giovanni Battista Ferrero, Brunhilde Wirth, Alfredo Brusco

Summary: Pavinato et al. describe a novel autosomal dominant neurodevelopmental disorder associated with loss of CAPRIN1, a regulator of the transport/translation of neuronal mRNAs critical for synaptic plasticity. The disorder is characterized by language impairment/speech delay, intellectual disability, attention deficit hyperactivity disorder, and autism spectrum disorder. They demonstrate morphological and functional alterations associated with this disorder in human neuronal models.
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