Article
Multidisciplinary Sciences
Florian Hubrich, Nina M. Bosch, Clara Chepkirui, Brandon Morinaka, Michael Rust, Muriel Gugger, Serina L. Robinson, Anna L. Vagstad, Jorn Piel
Summary: Lipopeptides are a group of microbial natural products that are important for their antibacterial and antifungal properties, as well as their strong biosurfactant effects. Most lipopeptides consist of cyclic peptides with various fatty acyl groups at the N-terminus. In this study, ribosomally derived lipopeptides called selidamides were discovered through genome-guided approaches. These selidamides were found to be widely distributed across different bacterial phyla and have cyclic peptide moieties with fatty acyl units attached to ornithine or lysine side chains. Unlike nonribosomal lipopeptides, selidamides are selectively acylated with different fatty acids. This study highlights the ability of ribosomal pathways to produce diverse lipopeptides and expands the potential for peptide drug development and targeted discovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Inga S. Shchelik, Karl Gademann
Summary: This study investigates the effect of newly synthesized cephalosporin derivatives with cyclic disulfide modifications on various strains of bacteria and biofilm formation. The incorporation of asparagusic acid was found to improve the activity of the drug against Gram-negative strains and reduce biofilm formation for Staphylococcus aureus and Pseudomonas aeruginosa. This suggests that incorporating cyclic disulfides may be an additional strategy to enhance antibiotic activity and combat bacterial infections.
ACS INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Manuela Voracova, Matej Zore, Jari Yli-Kauhaluoma, Paula Kiuru
Summary: This comprehensive review summarizes the use of phosphorus-containing compounds in antibacterial agents, including their role as β-lactamase inhibitors and antibacterial disinfectants. Phosphorus can serve as a pharmacophore to modify pharmacodynamic and pharmacokinetic properties.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Food Science & Technology
Lin Yue, Min Wang, Imran Mahmood Khan, Sobia Niazi, Bin Wang, Xiaoyuan Ma, Zhouping Wang, Wenshui Xia
Summary: Novel chitosan oligosaccharide derivatives modified with cinnamyl onto the NH2 position were synthesized in a one-step reaction, and their in vitro antibacterial activities were greatly improved compared to COS, sodium benzoate, and potassium sorbate. The derivatives showed DS-dependent antibacterial activities, with a higher sensitivity to S. aureus than E. coli. This study demonstrated the potential of the new derivatives as promising antimicrobial agents in the food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Qiaodeng Chen, Yepeng Xiang, Xiaojun Yin, Kai Hu, Yongfeng Li, Xiaoling Cheng, Yuan Liu, Guohua Xie, Chuluo Yang
Summary: Two bulky acridine moieties, DPAc and SpiroAc, were chosen as electron donors to create blue TADF emitters with high photoluminescent quantum yields in OLEDs. The molecules exhibited distinct TADF character and high external quantum efficiencies, demonstrating their potential for optoelectronic applications.
Article
Chemistry, Multidisciplinary
Simona Baroni, Rachele Stefania, Lionel M. Broche, Nicholas Senn, David J. Lurie, P. James Ross, Silvio Aime, Simonetta Geninatti Crich
Summary: This study introduces a novel class of MRI contrast agents with remarkable relaxation effects without the need for paramagnetic metal ions. Image acquisition at variable magnetic field strength is required for their detection using fast field cycling imaging scanners.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Xing Zhang, Hui He, Jiqian Xiang, Bin Li, Mengge Zhao, Tao Hou
Summary: The study showed that antioxidative peptides from selenium-containing soybeans exhibit high cellular antioxidant activity and protective effects against oxidative stress-related diseases. These peptides can be efficiently absorbed and reverse inflammatory responses in cells, while also inhibiting brain oxidative stress. Comparing with other forms of selenium, the synergistic effects of selenium and peptides in antioxidant activity were highlighted in this study.
Article
Polymer Science
Yu-Ting Fang, Feng Gan, Jie Dong, Xin Zhao, Xiu-Ting Li, Qing-Hua Zhang
Summary: In this study, high-performance polyimide fibers were successfully prepared by introducing a fully rigid coplanar symmetric heterocyclic unit into the macromolecular backbone structure. The detailed structural analysis revealed the characteristics and advantages of the copolyimide fibers, showing significant improvements in tensile strength and modulus.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Feng Bao, Zhixin Dong, Ran Zhang, Fuling Qi, Xuemin Dai, Xuepeng Qiu
Summary: By incorporating HBOA as the third monomer, high-performance PI fibers with excellent thermal stability and mechanical properties were successfully fabricated. The co-PI fibers exhibited optimal mechanical properties at a suitable PRM/HBOA molar ratio. The relationship between structure and mechanical property was also studied.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Food Science & Technology
Houchuntai Wang, Zongcai Tu, Hui Wang
Summary: Collagen peptides are widely used as dietary supplements, bioactive ingredients in cosmetics, healthcare, and pharmaceuticals. This study aimed to prepare high-content collagen peptides from different raw materials and evaluate their biological activities. Porcine gelatin showed the highest content of collagen peptides after enzymatic digestion and isolation and purification. Increasing the content of collagen peptides enhanced antioxidant capacity and the ability to promote the growth of human dermal fibroblasts.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Anqi Yu, Yang Ji, Gaoxing Ma, Juan Xu, Qiuhui Hu
Summary: In this study, selenium-containing peptides were prepared from selenium-enriched Pleurotus eryngii protein hydrolysates, and the effects of these peptides on lead-induced oxidative stress were evaluated. The results showed that selenium-containing peptides were able to reduce reactive oxygen species levels, regulate the Keap1/Nrf2 pathway, increase antioxidant enzyme activity, and alleviate cell apoptosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Biochemistry & Molecular Biology
Kainat Ahmed, Delawar Ashraf, Ghayoor Abbas Chotana, Amir Faisal, Khalid Mohammed Khan, Rahman Shah Zaib Saleem
Summary: Selenium, as a trace element, plays important biological roles, including neuroprotection, anti-inflammatory, anticancer, antioxidant, hepatoprotective, and immunomodulatory activities. Selenium-containing peptides, such as selenoproteins, offer more health benefits compared to traditional selenium supplements.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yunxue Li, Jiazhi Liu, Qingqing Zhou, Jie Zhao, Ping Wang
Summary: A new method has been introduced for converting peptide acyl hydrazide into peptide selenoester, which can be used for high-yield peptide ligation without racemization. This method provides a useful alternative for accessing peptide C-terminal selenoesters in protein ligation.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Maryam Soleymani, Mohammad Hassani, Ali Asakereh, Sepideh Khoee
Summary: Micro/nanomotors are small artificial devices that convert different forms of energy into movement. Enzyme-powered nanomotors have gained attention in the biomedical field due to their biocompatibility, versatility, and availability of fuel. In this study, Janus enzymatic nanomotors were synthesized using magnetic iron oxide nanoparticles as a core. Different amounts of Candida Antarctica lipase B (CALB) were immobilized in the nanoparticles, resulting in multi-stimuli propelled nanomotors. The velocity of the nanomotors was found to change based on the enzyme concentration, and the optimal hydrolysis rate and maximum speed were determined. The effect of near-infrared (NIR) light on the velocity of the nanomotors was also investigated.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ona Illa, Jimena Ospina, Jose-Emilio Sanchez-Aparicio, Ximena Pulido, Maria Angeles Abengozar, Nerea Gaztelumendi, Daniel Carbajo, Carme Nogues, Luis Rivas, Jean-Didier Marechal, Miriam Royo, Rosa M. Ortuno
Summary: The newly synthesized hybrid beta,gamma-peptidomimetics show no toxicity on human tumoral cells but have limited cell uptake ability. They exhibit some antimicrobial activity against Leishmania parasites, but with modest intracellular accumulation. In contrast, the previously published gamma,gamma-peptidomimetics have higher antimicrobial activity and intracellular accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Paloma Garcia-Arroyo, Paula Navalpotro, Maria J. Mancheno, Elena Salagre, Jorge J. Cabrera-Trujillo, Enrique G. Michel, Jose L. Segura, Javier Carretero-Gonzalez
Summary: In this study, a novel two-dimensional polymer network, DAPT-TFP, was successfully synthesized and shown to exhibit high thermal and chemical stability. An application to conductive additive-free electrode demonstrated the potential of the material, with improved performance of the nanostructure through simple acidic treatment.
Article
Chemistry, Inorganic & Nuclear
Maria L. Buil, Alba Collado, Miguel A. Esteruelas, Mar Gomez-Gallego, Susana Izquierdo, Antonio Nicasio, Enrique Onate, Miguel A. Sierra
Summary: Rhodium and iridium diolefin catalysts are used for the acceptorless and base-free dehydrogenation of secondary alcohols, and their degradation during the reactions has been investigated. The study of the reactivity of the dimers has shown complex structural changes.
Article
Chemistry, Multidisciplinary
Fernando P. Cossio, Abel de Cozar, Miguel A. Sierra, Luis Casarrubios, Jaime G. Muntaner, Bimal K. Banik, Debasish Bandyopadhyay
Summary: Computational-experimental analysis has determined that the stereochemistry of the Staudinger reaction is closely associated with the nature of the imine, affecting the nucleophilic attack and electrocyclization steps. The impact of energetically accessible in situ isomerization patterns and substituents of the imine on the reaction's stereochemistry has been analyzed kinetically, with results supporting experimental findings.
Article
Chemistry, Inorganic & Nuclear
Sergio Aguado, Diego J. Vicent, Luis Casarrubios, Carmen Ramirez de Arellano, Miguel A. Sierra
Summary: This study prepared two series of silicon-supported hydrogenase mimics and nanostructures containing multiple mimics. These compounds were characterized and studied for their electrochemical properties. The results showed that these compounds were soluble in organic solvents and exhibited stable electrochemical behavior and electrocatalytic activity. Additionally, the integrity of the silicon cage was maintained even in the presence of acetic acid.
Article
Chemistry, Inorganic & Nuclear
Alejandro Torres, Alba Collado, Mar Gomez-Gallego, Carmen Ramirez de Arellano, Miguel A. Sierra
Summary: In this study, tetranuclear [Fe2S2] hydrogenase mimic complexes containing Pt(II), Ni(II), and Ru(II) complexes were synthesized and their electrochemical properties were investigated. The incorporation of metal complexes in the structure modulated the electronic communication between the redox-active [Fe2S2] centers. Specifically, the structure of the phosphine ligand in the Pt compounds played a crucial role in facilitating or hindering the electronic communication, while the addition of a Ru-bis(bipyridine) complex promoted the communication. These experimental and computational findings provide insights into the electronic interaction between redox-active centers in hydrogenase.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Carmen Lorenzo-Aparicio, Sonia Moreno-Blazquez, Montserrat Olivan, Miguel A. Esteruelas, Mar Gomez Gallego, Pablo Garcia-Alvarez, Javier A. Cabeza, Miguel A. Sierra
Summary: The synthesis of Pt pincer complexes derived from purine and purine nucleosides is reported. The complexes have different coordination points due to the structure of the purine skeleton and substituents on the phenyl ring. The complexes show regioselectivity and have potential applications as interstrand cross-linking models.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Alejandro Torres, Diego J. Vicent, Alba Collado, Mar Gomez-Gallego, Carmen Ramirez de Arellano, Miguel A. Sierra
Summary: A new phosphite ligand with three [(mu-ADT)RFe2(CO)6] (R= p-HOC6H4) moieties (2) was successfully synthesized by the reaction of [(mu-ADT)RFe2(CO)6] (R= p-HOC6H4) 1a with PCl3. Coordination of this phosphite to [PdCl2(MeCN)2] or [PtCl2(DMSO)2] resulted in the formation of heterometallic square planar complexes 5. Reaction of phosphite 2 with [MCl2Cp*]2 (M = Rh, Ir) yielded three-legged piano stool complexes 6. The versatility of this new ligand in forming different heteropolymetallic complexes under mild reaction conditions was demonstrated by the formation of complexes 5 and 6.
Article
Chemistry, Physical
Daniele Antermite, Andrew J. P. White, Luis Casarrubios, James A. Bull
Summary: This study presents a combined experimental and computational investigation on the regio- and stereoselective C4 arylation of pyrrolidines and piperidines using C3 aminoquinoline amide directing groups. The mechanistic experiments reveal a cis-selective pathway and the discovery of an improved directing group. This study contributes to the understanding and improvement of C-H functionalization of N-heterocycles.
Article
Chemistry, Organic
Marta G. Avello, Maria Moreno-Latorre, Maria C. de la Torre, Luis Casarrubios, Heinz Gornitzka, Catherine Hemmert, Miguel A. Sierra
Summary: Triazolylidene MIC M-complexes (M = Au, Pd, Pt) with 2-azetidinones and penicillin G substituents at the triazole ring were synthesized and their catalytic properties were investigated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Carmen Lorenzo-Aparicio, Mar Gomez Gallego, Carmen Ramirez de Arellano, Miguel A. Sierra
Summary: In this study, new types of neutral and cationic phosphorescent complexes derived from 6-phenylpurine nucleosides and nucleotides were prepared and studied. The neutral complexes exhibit orange-red emission upon photoexcitation, while the cationic complexes emit yellow-green light.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Alejandro Torres, Alba Collado, Mar Gomez-Gallego, Carmen Ramirez de Arellano, Miguel A. Sierra
Summary: TTF and exTTF-containing complexes were prepared by the photochemical reaction with [(??-S2)Fe2(CO)6]. These complexes can interact with PAHs, and exhibit an electrocatalytic dihydrogen evolution reaction under certain conditions. The presence of air influences the electrochemistry of these systems, suggesting potential for the design of hydrogenase mimics combining the properties of [FeFe] cores with unique TTF properties.
ACS ORGANIC & INORGANIC AU
(2022)
Review
Chemistry, Inorganic & Nuclear
Mar Gomez-Gallego, Miguel A. Sierra
Summary: Hydrogen production is crucial for carbon-free energy production, and using hydrogenase mimics is an important approach to enhance efficiency. The use of isotopes, such as deuterium, can help unravel key steps in hydrogen generation mechanisms.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Samara Medina Rivero, Paloma Garcia Arroyo, Liang Li, Suman Gunasekaran, Thijs Stuyver, Maria Jose Mancheno, Mercedes Alonso, Latha Venkataraman, Jose L. Segura, Juan Casado
Summary: Experimental and modeling studies have shown that 1,1,2,2-tetrakis(4-aminophenyl)ethene can form molecular junctions with gold electrodes for single-molecule conductance measurements, exhibiting only two regimes of conduction. The linear transmission is achieved through-bond, while the cross-conjugated channel is further assisted by through-space transmission, partially alleviating destructive quantum interference.
CHEMICAL COMMUNICATIONS
(2021)
