期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 35, 页码 5957-5964出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800850
关键词
Calixarenes; Chiral resolution; Host-guest systems; Asymmetric catalysis; Michael addition; Organocatalysis
Newly designed, inherently chiral calix[4]arenes containing amino phenol structures have been synthesized and resolved to optically pure forms. The enantiomeric recognition ability of one chiral calix[4]arene was examined with mandelic acid by H-1 NMR spectroscopy, and we found that the inherently chiral calix[4]arene could be used as a chiral NMR solvating agent to determine the enantiopurity of mandelic acid at ambient temperature. In addition, the chiral calix[4]arenes were used as organocatalysts in asymmetric Michael-type addition reactions of thiophenols, and high catalytic efficiency with low enantioselectivity was observed. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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