Straightforward synthesis of fluorinated amphiphilic thiols

C8-perfluoroalkyl thiols bearing a polyoxyethylene chain of variable length were prepared in good yields following a straightforward synthetic strategy. These thiols are soluble in organic solvents of different polarities from chloroform to methanol. The thiol with a PEG550 chain shows very good solubility in water. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).