期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2008, 期 16, 页码 2746-2750出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800018
关键词
N-heterocycles; benzimidazole; benzimidazolone; imidazole; N-arylation; cross-coupling
This paper describes copper-catalyzed N-C heteroarylation of benzimidazole, 1-methylbenzimidazolone, imidazole and pyrrole. The products of these reactions then undergo palladium-catalyzed C-C cross-couplings with aryl or heteroaryl-boronic acids under Suzuki-Miyaura conditions to provide a rapid entry, from readily-available reagents, into tris(hetero)-aryl scaffolds comprising two or three N-heterocyclic rings. The sequential N-C and C-C couplings can be performed in a one-pot process (two examples are given: > 50% overall yields). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
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