Article
Neuroimaging
Michael J. Firbank, Katrina daSilva Morgan, Daniel Collerton, Greg J. Elder, Jehill Parikh, Kirsty Olsen, Julia Schumacher, Dominic Ffytche, John-Paul Taylor
Summary: This study investigated structural brain changes in patients with Charles Bonnet Syndrome (CBS) using magnetic resonance imaging (MRI). The findings suggest that there are cortical and subcortical effects associated with sight loss, but structural changes alone cannot explain the occurrence of visual hallucinations. CBS may be related to changes in connectivity or excitability in brain networks linked to vision.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Lomelin-Lopez Diana, Jaime Carmona-Huerta, J. Guillermo Patino, Aldana-Lopez Alejandro, Durand-Arias Sol
Summary: Charles Bonnet Syndrome (CBS) presents with visual hallucinations and preserved reality judgment, often associated with alterations in the optic pathway. Atypical clinical presentations may indicate underlying structural pathologies in the central nervous system, necessitating a thorough evaluation for optimal diagnosis and treatment. In this case, a frontal tumor lesion adjacent to the olfactory groove and compression of the optic chiasm led to visual hallucinations and depressive symptoms, highlighting the importance of considering basic structural pathologies in cases of isolated visual hallucinations.
Review
Ophthalmology
Yousif Subhi, Diana Chabane Schmidt, Daniella Bach-Holm, Miriam Kolko, Amardeep Singh
Summary: The prevalence of Charles Bonnet Syndrome (CBS) in patients with glaucoma varies depending on different factors such as age, gender, and visual acuity. The existing literature has limitations and more studies are needed to gain a better understanding of CBS among patients with glaucoma.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Katrina daSilva Morgan, Julia Schumacher, Daniel Collerton, Sean Colloby, Greg J. Elder, Kirsty Olsen, Dominic H. Ffytche, John-Paul Taylor
Summary: This study investigated the potential therapeutic benefits and tolerability of inhibitory transcranial direct current stimulation (tDCS) in treating visual hallucinations in patients with CBS. The results showed that tDCS of the visual cortex significantly reduced the frequency of visual hallucinations, especially in individuals with higher occipital excitability prior to stimulation. The treatment was found to be feasible and without significant side effects.
Article
Ophthalmology
Marta Isabel Martinez-Sanchez, Gema Bolivar
Summary: This case report describes a 78-year-old man with Charles Bonnet syndrome as the initial presentation of occipital infarction, despite preserved visual acuity. The patient experienced visual hallucinations of flowers and fruits intermittently for two months, which improved over time without any specific treatment. It is important to consider Charles Bonnet syndrome in patients with non-disturbing visual hallucinations, even in the presence of good visual acuity.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Hanako Sasaki, Yasunori Fujimoto, Hiroyuki Ima, Yu Kageyama
Summary: A 74-year-old man presented with complex visual hallucinations, with MRI showing a right occipital falx meningioma. FDG-PET imaging revealed hypometabolism in the right primary and secondary visual cortices, and hypermetabolism in the ventral visual pathway.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Psychiatry
Charmi Balsara, Alexander Shahin, Niharika Baviriseaty, Richard Czuma, Gregory A. Sullivan
Summary: Charles Bonnet syndrome is a disorder of visual hallucinations that occurs in psychologically normal patients with ocular disease or damage to visual pathways. The cause of CBS is not fully understood and it is often triggered by conditions such as age-related macular degeneration. Visual disturbances, including decreased visual acuity, visual field deficits, and visual hallucinations, are common symptoms.
JOURNAL OF PSYCHIATRIC PRACTICE
(2022)
Article
Psychiatry
Arda Karagol
Summary: The prevalence of CBS in younger patients was found to be 17.9%, which is consistent with the medical literature. Patients with CBS may experience negative emotions related to their hallucinations, and inquiring about this symptom during clinical examination could be the first step in helping these individuals.
PSYCHIATRIA DANUBINA
(2021)
Article
Medicine, General & Internal
Francisco J. Somoza-Cano, Ahmed Abuyakoub, Faris Hammad, Jasmin Jaber, Abdul Rahman Al Armashi
Summary: Charles Bonnet syndrome is a clinical entity characterized by visual hallucinations in patients with declining visual acuity and no underlying neuropsychiatric disorder. Clinical suspicion and reassurance are crucial for adequate patient care when encountering such cases.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
MaryKate Voit, Brian Jerusik, Justin Chu
Summary: CBS presents as vision loss and visual hallucinations in neurologically and psychiatrically intact patients. The syndrome can be caused by ophthalmologic disease or cerebral vascular issues. Diagnosis may be delayed due to patient reluctance to report symptoms and lack of physician awareness.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Suluma Aslan, Gloria Ngajilo, Azan Nyundo
Summary: This case discusses the complex neuropsychiatric manifestations, including complex visual hallucinations and visual impairment, in geriatrics due to recurrent pituitary macroadenoma. Remission of hallucination occurred within 2 weeks of oral administration of 1.5 mg of haloperidol once daily; this is a rare case of Charles Bonnet syndrome after recurrent pituitary macroadenoma.
CLINICAL CASE REPORTS
(2023)
Article
Medicine, General & Internal
Ricardo Irizarry, Ariel Sosa Gomez, Jean Tamayo Acosta, Leonel Gonzalez Diaz
Summary: This paper discusses the neuropsychiatric sequelae associated with traumatic brain injuries and presents a case of visual hallucinations consistent with Charles Bonnet syndrome.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Cell Biology
Andrea Piarulli, Jitka Annen, Ron Kupers, Steven Laureys, Charlotte Martial
Summary: This study revealed specific changes in electrical brain activity in CBS patients during visual hallucinations, including alterations in power and connectivity between different brain areas, changes in network properties, and increased signal complexity. These findings suggest that the emergence of hallucinations in CBS may be related to disruptions in the visual cortex and core cortical regions involved in attention and default mode networks.
Article
Medicine, General & Internal
Vesna Tepsic Ostojic, Zagorka Gojkovic, Bratislav Zivic
Summary: Charles Bonnet syndrome is a condition characterized by complex visual hallucinations due to visual impairment, with retention of insight. It is often misdiagnosed as psychosis or early stages of dementia, and is underreported by patients due to fear of being diagnosed with a mental illness.
VOJNOSANITETSKI PREGLED
(2023)
Article
Behavioral Sciences
Timothy Lawn, Dominic Ffytche
Summary: Hallucinations are perceptual experiences in the absence of external stimuli, shared features between eye-disease and Parkinson's disease. Structural changes in the cerebellum have been linked to visual hallucinations, independent of specific mechanisms. Lower GMV in cerebellar lobule VIII and IX/VII was observed in hallucinators, with PD patients showing more significant reductions in Crus 1 GMV. Additionally, PD patients exhibited lower WMV in the medulla in relation to hallucinations.
Article
Ophthalmology
Beatriz de Luis Eguileor, Pedro Arriola-Villalobos, Jose Ignacio Pijoan Zubizarreta, Raquel Feijoo Lera, Alaitz Santamaria Carro, David Diaz-Valle, Jaime Etxebarria
Summary: The study assessed the repeatability and reliability of tomographic parameters for characterizing keratoconus measured with a Pentacam HR. Results showed excellent ICCs for all parameters, with repeatability limits varying for different parameters, supporting the usefulness of Pentacam HR for diagnosing keratoconus. New criteria should be established for monitoring progression based on real measurements from this system.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Carmen Mendez-Hernandez, Surina Wang, Paula Arribas-Pardo, Liseth Salazar-Quinones, Noemi Guemes-Villahoz, Cristina Fernandez-Perez, Julian Garcia-Feijoo
Summary: The study found significant differences in multiple indicators between patients with retinal diseases and normal subjects, with the wcpVD, iVD, wmVD, and ONH Hb showing the most prominent differences.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Jose Ignacio Fernandez-Vigo, Hang Shi, Bachar Kudsieh, Lucia De-Pablo-Gomez-de-Liano, Jose angel Fernandez-Vigo, Julian Garcia-Feijoo
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Pedro Arriola-Villalobos, Aina Moll-Udina, Mario Carrasco-Lopez-Brea, Cristina Sacristan, Maria Jose Capella, Diana Peiteado, Ana Garrote-Llorden, Mara Albert Fort, Margarita Jodar Marquez, Juan Jacobo Gonzalez Guijarro, Rosalia Demetrio-Pablo, Juan Luis Sanchez Sevilla, Ester Carreno, Julio Gonzalez-Lopez, Lucia Miguel-Escuder, Carlos Cuadros, David Diaz-Valle, Alfredo Adan, Jose M. Benitez del Castillo, Alejandro Fonollosa, Miguel Cordero, Lucia Martinez Costa, Ricardo Blanco-Alonso
Summary: In Spain, VKH mainly affects women with incomplete acute stage disease. Corticosteroids are the most common treatment, and the most frequent complications are cataract and ocular hypertension.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Noemi Guemes-Villahoz, David Diaz-Valle, Alex Fonollosa, Maria Jimenez-Santos, Carlos Narvaez-Palazon, Alfredo Adan
Summary: Epiretinal membrane (ERM) is a common complication of uveitis and can lead to vision loss. While there have been only two case reports in the scientific literature depicting spontaneous regression of inflammation-associated ERM, spontaneous separation is a rare but possible event.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Pedro Arriola-Villalobos, Barbara Burgos-Blasco, Beatriz Vidal-Villegas, Carlos Oribio-Quinto, Mayte Arino-Gutierrez, David Diaz-Valle, Jose Manuel Benitez-del-Castillo
Article
Clinical Neurology
Barbara Burgos-Blasco, Noemi Guemes-Villahoz, Beatriz Vidal-Villegas, Jose M. Martinez-de-la-Casa, Julian Garcia-Feijoo, Juan Donate-Lopez, Francisco J. Martin-Sanchez, Juan J. Gonzalez-Armengol, Carmen D. Mendez-Hernandez
Summary: The study aimed to evaluate the changes in peripapillary retinal nerve fiber layer (RNFL) thickness and vessel density (VD) in post-COVID-19 patients. The results showed that one year after SARS-CoV-2 infection, there were changes in RNFL thickness and vascularization, possibly indicating recovery in these parameters.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2022)
Article
Cell Biology
Barbara Burgos-Blasco, Beatriz Vidal-Villegas, Isabel Collado-Vincueria, Ana Maria Soria-Garcia, Ricardo Cuina-Sardina, Rosalia Mendez-Fernandez, David Diaz-Valle, Mayte Arino-Gutierez
Summary: This study reports the clinical results on the use of frozen corneas stored in Eusol-C as emergency tectonic grafts. The corneas were stored at -78 degrees C for an average of 6.9 months. The study found that long-term preservation of donor corneas in Eusol-C at -78 degrees C is a viable technique to meet the needs of emergency grafts.
CELL AND TISSUE BANKING
(2023)
Article
Ophthalmology
Lara Borrego-Sanz, Laura Morales-Fernandez, Federico Saenz-Frances San Baldomero, David Diaz Valle, Esperanza Pato Cour, Rosalia Mendez Fernandez, Julian Garcia Feijoo, Luis Rodriguez Rodriguez
Summary: Differences in corneal biomechanical properties were found between patients with non-infectious uveitis and healthy subjects.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Letter
Ophthalmology
Fernando Ly-Yang, Alfonso Miranda-Sanchez, Barbara Burgos-Blasco, Jose Ignacio Fernandez-Vigo, Jose Antonio Gegundez-Fernandez, David Diaz-Valle
JAMA OPHTHALMOLOGY
(2022)
Article
Oncology
Pilar Perez-Garcia, Barbara Burgos-Blasco, Veronica Gomez-Calleja, Beatriz Vidal-Villegas, Rosalia Mendez-Fernandez, Jose Antonio Gegundez-Fernandez, David Diaz-Valle
Summary: The efficacy and safety of 5-fluorouracil as a second-line treatment for conjunctival intraepithelial neoplasia refractive to interferon alpha-2b were reported. 5-fluorouracil treatment resulted in complete remission of the lesions in both cases without relapse. Fewer side effects were observed compared to other available alternatives.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2023)
Article
Ophthalmology
Alejandro Gomez-Gomez, Alfredo Madrid-Garcia, Lara Borrego-Sanz, Paula Alvarez-Hernandez, Pedro Arriola-Villalobos, Ines Perez-Sancristobal, Jose M. Benitez del Castillo, Rosalia Mendez-Fernandez, Esperanza Pato-Cour, David Diaz-Valle, Luis Rodriguez-Rodriguez
Summary: This study aimed to identify factors affecting the response rate to immunosuppressive drugs (ISDs) in patients with non-infectious uveitis (NIU). The results showed that uveitic macular edema at prescription and a higher oral corticosteroid dose in the year before ISD prescription were associated with a lower hazard for achieving good therapeutic response (GTR). On the other hand, prescribing cyclosporine and previous use of multiple ISDs were associated with higher GTR rates.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
M. Jimenez-Santos, F. Saenz-Frances, O. Rodriguez-Quet, I. Cervan-Lopez, E. Santos-Bueso, J. M. Martinez-de-la-Casa, L. Janez-Escalada
Summary: This study aimed to evaluate the dependence of corneal hysteresis on non-central corneal thickness, finding a significant association between corneal thickness in different circular zones and CH. The model of corneal thickness segmentation explains a portion of the variation in CH measurements.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2023)
Article
Ophthalmology
Barbara Burgos-Blasco, David Diaz-Valle, Daniela Rego-Lorca, Pilar Perez-Garcia, Virginia Puebla-Garcia, Jose Ignacio Fernandez-Vigo, Jose Manuel Benitez-del-Castillo, Jose Antonio Gegundez-Fernandez
Summary: The efficacy of topical insulin eye drops in reducing corneal staining and improving symptoms of refractory dry eye disease was evaluated in this retrospective case series. The results showed that topical insulin was a promising treatment option for patients with epithelial damage in dry eye disease.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)