期刊
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
卷 170, 期 1, 页码 165-170出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejogrb.2013.06.013
关键词
Polycystic ovary syndrome; Late reproductive age; Gonadal axis; Ovarian reserve
资金
- National Fund for Scientific and Technological Research (Fondecyt) [1110864]
- Chilean Endocrine and Diabetes Society [SOCHED 2009-05]
- Alexander von Humboldt Foundation
Objective: To assess gonadotrophin secretion, ovarian steroid production and ovarian reserve in PCOS women during the onset of reproductive decline, in order to characterize their ovarian function at this age. Study design: Forty PCOS patients and 35 healthy women (35-40 years of age) were included. Clinical history, anthropometry,. transvaginal ultrasound and a leuprolide acetate test (10 mu g/kg s.c.) were performed. Gonadotrophins, steroid hormones, SHBG, inhibin B and AMH were determined. Results: Basal and peak LH levels were similar in both groups. Basal and peak FSH levels were significantly higher in the control group. Androgens, peak oestradiol, ovarian volume, antral follicle count and AMH levels were significantly higher in PCOS patients. Conclusion: These observations suggest that during late reproductive age, gonadotrophin secretion in women with PCOS is clearly different from that observed in control women and may also differ from that of younger PCOS patients. New features like normal LH and lower FSH levels associated with a higher ovarian reserve may give a different reproductive profile to these women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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