Article
Biochemistry & Molecular Biology
Mariana Lima Mascarenhas Moreira, Iana Mizumukai de Araujo, Sandra Yasuyo Fukada, Lucas Gabriel R. Venturini, Natalia Rossin Guidorizzi, Carlos Ernesto Garrido, Clifford J. Rosen, Francisco Jose Albuquerque de Paula
Summary: This cross-sectional observational study aimed to assess adipose tissue in DS patients and define their bone phenotype. DS patients showed increased adiposity in the lumbar spine and muscle tissue, as well as impaired bone quality and lower bone mass in the 1/3 radius. The study also found associations between insulin resistance, lipids, bone turnover markers, and bone parameters in DS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Valeria Calcaterra, Elvira Verduci, Martina Chiara Pascuzzi, Vittoria Carlotta Magenes, Giulia Fiore, Elisabetta Di Profio, Elisavietta Tenuta, Alessandra Bosetti, Carolina Federica Todisco, Enza D'Auria, Gianvincenzo Zuccotti
Summary: Obesity is characterized by excessive fat accumulation and has negative health consequences. In children, obesity is associated with an increased risk for diseases such as type 2 diabetes and cardiovascular events. The ketogenic diet has been proposed as a promising intervention for addressing metabolic and cardiovascular risk factors related to obesity.
Article
Multidisciplinary Sciences
Valeria Nobrega da Silva, Tamara Beres Lederer Goldberg, Carla Cristiane Silva, Cilmery Suemi Kurokawa, Luciana Nunes Mosca Fiorelli, Anapaula da Conceicao Bisi Rizzo, Jose Eduardo Corrente
Summary: Metabolic syndrome may be associated with reduced bone mineral density and biochemical markers of bone formation and resorption in adolescents with excess weight, as observed through a cross-sectional study evaluating 271 adolescents.
Article
Nutrition & Dietetics
Susan Wolver, Kristen Fadel, Ethan Fieger, Zein Aburish, Brennen O'Rourke, Toni-Marie Chandler, Dorian Shimotani, Natasha Clingempeel, Shuchi Jain, Aashish Jain, Puneet Puri
Summary: This study shows that in patients with T2DM on a Low Carbohydrate Diet (LCD), it is possible to reduce or even discontinue insulin use while facilitating weight loss and achieving glycemic control. Offering a Low Carbohydrate Diet to all patients with diabetes, especially those using insulin, is recommended based on these findings.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ye Tian, Wei Lu, Ruicheng Shi, Reagan Mcguffee, Richard Lee, David A. Ford, Bo Wang
Summary: The study reveals that targeting LPCAT3 could be a novel therapy for insulin resistance, as suppression of Lpcat3 expression improves insulin sensitivity and metabolic issues in diabetic mice.
Review
Biochemistry & Molecular Biology
Antonio Mancini, Carmine Bruno, Edoardo Vergani, Claudia d'Abate, Elena Giacchi, Andrea Silvestrini
Summary: The pathophysiology of PCOS involves complex mechanisms such as obesity, insulin-resistance, oxidative stress, and low-grade inflammation, which may lead to obesity, insulin resistance, vitamin D deficiency, and immune dyscrasia. These factors can interact and exacerbate each other's effects, suggesting an inverse interaction from the traditional understanding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Elena Tragni, Luisella Vigna, Massimiliano Ruscica, Chiara Macchi, Manuela Casula, Alfonso Santelia, Alberico L. Catapano, Paolo Magni
Summary: The multi-center VLCKD program conducted in a real-world setting for overweight/obese women was shown to be safe and effective, resulting in significant improvements in cardiometabolic parameters, substantial reductions in body weight and waist circumference.
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Endocrinology & Metabolism
Rongya Tao, Oliver Stohr, Caixia Wang, Wei Qiu, Kyle D. Copps, Morris F. White
Summary: This study found that disruption of hepatic insulin signaling can reduce adipose mass and increase energy expenditure in mice, preventing obesity. Moreover, a protein called Fst produced by the liver was found to regulate energy expenditure through its effects on muscles, revealing the important communication between the liver and muscles in controlling energy balance and obesity.
MOLECULAR METABOLISM
(2023)
Article
Nutrition & Dietetics
Aline B. Santamarina, Lais V. Mennitti, Esther A. de Souza, Leonardo M. de Souza Mesquita, Isau H. Noronha, Jose Ronnie C. Vasconcelos, Carla M. Prado, Luciana P. Pisani
Summary: This study found that a low-carbohydrate diet pattern promotes weight loss and improves glucose intolerance in obesity. Additionally, the quality of lipids, specifically the consumption of 6)-3 polyunsaturated and 6)-9 monounsaturated lipids, has a direct influence on improving glucose intolerance, lipid metabolism, and anti-inflammatory effects.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Amanda A. Greenwell, Christina T. Saed, Seyed Amirhossein Tabatabaei Dakhili, Kim L. Ho, Keshav Gopal, Jordan S. F. Chan, Oksana O. Kaczmar, Scott A. Dyer, Farah Eaton, Gary D. Lopaschuk, Rami Al Batran, John R. Ussher
Summary: Ketogenic diets did not effectively promote fat loss or improve glucose homeostasis in obese mice, while a low-fat and high-complex carbohydrate diet resulted in beneficial changes in body composition and improved glucose tolerance. Therefore, caution should be taken when considering ketogenic diets as a non-pharmacological strategy for obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Cell Biology
Brandee Goo, Samah Ahmadieh, Abdalrahman Zarzour, Nicole K. H. Yiew, David Kim, Hong Shi, Jacob Greenway, Stephen Cave, Jenny Nguyen, Swetha Aribindi, Mark Wendolowski, Praneet Veerapaneni, Mourad Ogbi, Weiqin Chen, Yun Lei, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub
Summary: Obesity is a major risk factor for metabolic and cardiovascular diseases. Research has found that adipocyte-specific deletion of the HDAC9 gene can alleviate obesity and metabolic diseases in female mice, but the effect is less significant in male mice. These findings reveal sex-related differences in the contribution of HDAC9 to obesity-related metabolic diseases.
Article
Cardiac & Cardiovascular Systems
Ji Eun Jun, Min Sun Choi, Sung Woon Park, Gyuri Kim, Sang-Man Jin, Kyunga Kim, You-Cheol Hwang, Kyu Jeung Ahn, Ho Yeon Chung, In-Kyung Jeong, Mira Kang, Jae Hyeon Kim
Summary: This study investigated the association between SMM and CAC, finding that low SMM was significantly associated with an elevated risk of CAC presence, incidence, and progression.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Domenico Trico, Alfonso Galderisi, Michelle A. Van Name, Sonia Caprio, Stephanie Samuels, Zhongyao Li, Brittany T. Galuppo, Mary Savoye, Andrea Mari, Ariel E. Feldstein, Nicola Santoro
Summary: This study aimed to investigate the effects of a low n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio diet on obese youth and its impact on metabolism. The results showed that the diet increased insulin clearance, improving hyperinsulinaemia in obese youth, independently of weight loss, glucose concentrations, and insulin secretion.
DIABETES OBESITY & METABOLISM
(2022)