Article
Biochemistry & Molecular Biology
Seita Chudan, Riko Ishibashi, Miyu Nishikawa, Yoshiaki Tabuchi, Yoshinori Nagai, Shinichi Ikushiro, Yukihiro Furusawa
Summary: This study found that soluble oat fibers ameliorate T cell-dependent colitis by inducing peripherally induced regulatory T cells (pTregs) and increasing colonic butyrate production. Soluble oat fibers promote the growth of butyrate-producing bacteria in the gut microbiome, increase the concentration of butyrate, and alleviate weight loss and inflammation in acute colitis.
Article
Multidisciplinary Sciences
Asma Amamou, Matthieu Rouland, Linda Yaker, Alexis Goichon, Charlene Guerin, Moutaz Aziz, Guillaume Savoye, Rachel Marion-Letellier
Summary: The study suggests that high salt diet may exacerbate intestinal fibrosis and contribute to worsen chronic inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Plant Sciences
Qian Xie, Hongyan Li, Rong Ma, Mihong Ren, Yong Li, Jinxiu Li, Hai Chen, Zhuoping Chen, Daoyin Gong, Jian Wang
Summary: In this study, the therapeutic effects of Coptis chinensis Franch and Magnolia officinalis on TNBS-induced ulcerative colitis in rats were investigated. It was found that these herbal medicines could improve disease indicators, reduce colonic mucosal damage, and regulate intestinal flora. They also showed anti-inflammatory effects and protected the integrity of the tight junction, indicating their potential in preventing intestinal barrier damage.
Article
Pharmacology & Pharmacy
Karuppusamy Arunachalam, Amilcar Sabino Damazo, Antonio Macho, Monica Steffi Matchado, Eduarda Pavan, Fabiana de Freitas Figueiredo, Darley Maria Oliveira, Carrie A. Duckworth, Parimelazhagan Thangaraj, Marco Leonti, Domingos Tabajara de Oliveira Martins
Summary: Canthin-6-one has anti-inflammatory and antioxidant effects on colitis, reducing intestinal damage and improving inflammatory markers. It has the potential therapeutic benefit for inflammatory bowel disease by regulating molecular immune mediators.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Peter Michael Reil, Teodor Traian Maghiar, Narcis Vilceanu, Andrei Pascalau, Claudia Teodora Judea Pusta, Florin Marcu, Simona Cavalu, Ovidiu Pop
Summary: The study found that in patients who died of septic shock, the expression levels of CD14 in heart tissue were correlated with adverse patient outcomes, indicating that CD14 could be a valuable marker for septic cardiomyopathy.
Article
Immunology
Xufei Zhang, Magali Monnoye, Mahendra Mariadassou, Fabienne Beguet-Crespel, Nicolas Lapaque, Christine Heberden, Veronique Douard
Summary: The study revealed different impacts of fructose and glucose intake on mice, with glucose leading to increased adiposity, glucose intolerance, and intestinal permeability, while fructose resulted in elevated IL6 levels. The research also identified the potential roles of microbiota composition and inflammatory factors in gut barrier function and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gayoung Kim, Kyeong-Hun Choi, Hangeun Kim, Dae-Kyun Chung
Summary: L. plantarum K8 lysates can modulate the inflammatory response induced by LPS in THP-1 cells, reduce TNF-alpha production, alleviate inflammation, and inhibit characteristics such as cell enlargement and macrophage infiltration in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Shucheng Zhang, Wenhua Jin, Weibo Zhang, Fazheng Ren, Pengjie Wang, Ning Liu
Summary: The study demonstrates that pea albumin has anti-inflammatory effects and can modulate gut microbiota in DSS-induced colitis. This suggests that pea albumin may play a protective role in the treatment of inflammatory bowel disease.
Article
Pharmacology & Pharmacy
Kehan Rao, Shumin Qin, Yuanming Yang, Kai Zhan, Haomeng Wu, Huan Zheng, Shaogang Huang
Summary: The study found that shenling baizhu powder (SBP) has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis. SBP effectively strengthens the epithelial barrier integrity in colitis patients by increasing the secretion of mucin and tight junction proteins while inhibiting apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Vrushali R. Hambardikar, Deepa S. Mandlik
Summary: The study demonstrated that treatment with NG effectively alleviated TNBS-induced colitis in rats by improving body weight, hematological parameters, reducing spleen and colon weight, alleviating symptoms, as well as decreasing inflammatory response and repairing tissue damage.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Immunology
Huifang Xiong, Guohui Xue, Yuting Zhang, Shuang Wu, Qiaoyun Zhao, Rulin Zhao, Nanjin Zhou, Yong Xie
Summary: The study aimed to investigate the effects of Gal-9 on experimental colitis. The results showed that exogenous Gal-9 increased Tim-3 expression, inhibited the TLR4/NF-kappa B pathway, and alleviated TNBS-induced colitis in mice. However, it had no reducing effect on DSS-induced colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Yanxia Fu, Chen Zhang, Hui Xie, Zisheng Wu, Yurong Tao, Ziyu Wang, Meng Gu, Panjian Wei, Shuye Lin, Ruoran Li, Yuqi He, Jianqiu Sheng, Junfeng Xu, Jinghui Wang, Yuanming Pan
Summary: The study demonstrates that HUMSCs can significantly improve disease symptoms and pathological changes in TNBS-induced colitis mice, improve the gut microbiota, and rebalance the immune system by increasing the abundance of healthy bacteria, Firmicutes/Bacteroidetes ratio, and Treg proportion while decreasing the Th1/Th17 ratio. Furthermore, the expression levels of IFN-gamma and IL-17 were significantly decreased, and TGF-beta 1 levels were significantly increased in the plasma of colitis mice HUMSC injection.
Article
Biochemistry & Molecular Biology
Xuebin Yang, Xin Sun, Feng Zhou, Shuiping Xiao, Lulu Zhong, Shian Hu, Zhe Zhou, Ling Li, Yang Tan
Summary: Protocatechuic acid (PCA) is a natural component with multiple biological activities. This study investigated the effects of PCA on anti-ulcerative colitis (UC) and found that PCA reduced the levels of disease activity index, inflammatory factors, and histological damage in UC mice. The regulation of intestinal flora and the inhibition of ferroptosis were suggested as potential mechanisms underlying the protective effects of PCA against UC.
Article
Plant Sciences
Ruberlei Godinho de Oliveira, Amilcar Sabino Damazo, Layren Ferreira Antonielli, Fabio Miyajima, Eduarda Pavan, Carrie A. Duckworth, Joaquim Corsino da Silva Lima, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins
Summary: The hydroethanolic extract of inner stem bark of Dilodendron bipinnatum (HEDb) demonstrated anti-inflammatory and anti-ulcerative colitis properties in an experimental colitis model. HEDb reduced the production of inflammatory cytokines like TNF-alpha in rats and Caco-2 cell line, increased mucus production, reduced leukocyte migration, and inhibited some inflammatory and oxidative events.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Chiara Sinisgalli, Teresa Vezza, Patricia Diez-Echave, Angela Ostuni, Immacolata Faraone, Laura Hidalgo-Garcia, Daniela Russo, Maria Francesca Armentano, Jose Garrido-Mesa, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales, Luigi Milella, Julio Galvez
Summary: The extract from red sweet peppers with the best antioxidant properties, termed Capsicum annuum extract (CAE), was orally administered to mice fed a high fat diet in an experimental model. The CAE promoted weight loss, improved glucose and lipid metabolism, reduced systemic inflammation, restored gut barrier function, and modulated the intestinal microbiome, showing potential as a complementary approach for treating obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Alba Rodriguez-Nogales, Francesca Algieri, Julio Galvez, Pilar Aranda, Maria Montes-Bayon, Juan Llopis
Summary: The study found that diabetic rats had higher inflammatory status and lower hematological parameters, but these improved after treatment with V, with higher serum iron levels. V reduced the gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.
Review
Nutrition & Dietetics
Maria Jesus Rodriguez-Sojo, Antonio Jesus Ruiz-Malagon, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales
Summary: Probiotic microorganisms exert their health-associated activities through various mechanisms, with Limosilactobacillus fermentum CECT5716 standing out as a promising probiotic with anti-inflammatory and immunomodulatory properties. Studies have shown its potential beneficial effects on host health and future therapeutic approaches are being explored.
Review
Pharmacology & Pharmacy
Jose Garrido-Mesa, Kate Adams, Julio Galvez, Natividad Garrido-Mesa
Summary: Drug repurposing is a successful method to address the lack of cost-effective therapies in situations like the COVID-19 pandemic. Tetracyclines have shown efficacy in preclinical models of acute respiratory distress syndrome (ARDS) and have potential as an antiviral against SARS-CoV2. Despite limited scientific evidence, the multi-target pharmacology and safety profile of tetracyclines overcome limitations such as antibiotic activity and low commercial interest. Immunomodulatory tetracyclines and novel chemically modified non-antibiotic tetracyclines show therapeutic potential, and further drug repurposing studies in ARDS and severe COVID-19 are necessary.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Biochemistry & Molecular Biology
Antonio Jesus Ruiz-Malagon, Maria Jesus Rodriguez-Sojo, Laura Hidalgo-Garcia, Jose Alberto Molina-Tijeras, Federico Garcia, Ivo Pischel, Miguel Romero, Juan Duarte, Patricia Diez-Echave, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales, Julio Galvez
Summary: This study evaluated the effect of Thymus serpyllum extract on high-fat diet-induced obesity in mice. The extract displayed antioxidant activity and improved obesity and metabolic abnormalities, as well as reducing systemic inflammation. Additionally, the extract was found to modulate the gut microbiota, restoring microbial richness and diversity.
Review
Nutrition & Dietetics
Elena Gonzalez-Lozano, Jorge Garcia-Garcia, Julio Galvez, Laura Hidalgo-Garcia, Alba Rodriguez-Nogales, Maria Elena Rodriguez-Cabezas, Manuel Sanchez
Summary: Lactobacillus probiotics have beneficial effects on host health and various pathological conditions, especially in improving inflammatory bowel disease (IBD) and regulating the immune system. Extracellular vesicles (EVs) derived from probiotics play a key role in these interactions and have been proposed as a safe alternative to live bacteria for vulnerable patients. This review provides an updated overview of EVs from different Lactobacillus strains and their potential therapeutic applications.
Article
Nutrition & Dietetics
Maria Jesus Rodriguez-Sojo, Jorge Garcia-Garcia, Antonio Jesus Ruiz-Malagon, Patricia Diez-Echave, Laura Hidalgo-Garcia, Jose Alberto Molina-Tijeras, Elena Gonzalez-Lozano, Laura Lopez-Escanez, Maria Elena Rodriguez-Cabezas, Maria Jose Rodriguez-Sanchez, Alba Rodriguez-Nogales, Cristina Mediavilla, Julio Galvez
Summary: Limosilactobacillus fermentum CECT5716, a probiotic strain isolated from human milk, has shown beneficial effects on different gastrointestinal disorders and immune responses. In this study, its effects on an irritable bowel syndrome (IBS) rat model were assessed, showing improvements in behavior, hypersensitivity, inflammation, intestinal barrier integrity, and gut microbiota composition. These findings suggest the potential clinical use of Limosilactobacillus fermentum CECT5716 for IBS management.
Article
Biochemistry & Molecular Biology
Jose D. D. Puentes-Pardo, Sara Moreno-SanJuan, Jorge Casado, Julia Escudero-Feliu, David Lopez-Perez, Paula Sanchez-Uceta, Paula Gonzalez-Novoa, Julio Galvez, Angel Carazo, Josefa Leon
Summary: Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in various physiological processes. Elevated PARP-1 expression is found in several tumors, associated with stemness and tumorigenesis. In colorectal cancer patients, PARP-1 expression correlated with differentiation grade, with a significant association only in tumors with wild-type p53. Additionally, PARP-1 and cancer stem cell markers were positively correlated in these tumors. In vitro studies showed that PARP-1 regulates cancer stem cell phenotype depending on p53 status, with overexpression increasing marker expression and sphere forming ability in wild-type p53 cells, while reducing these features in mutated p53 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Enrique Guillamon, Nuria Mut-Salud, Maria Jesus Rodriguez-Sojo, Antonio Jesus Ruiz-Malagon, Antonio Cuberos-Escobar, Antonio Martinez-Ferez, Alba Rodriguez-Nogales, Julio Galvez, Alberto Banos
Summary: This study demonstrates the potential anti-proliferative and anti-inflammatory effects of onion-derived metabolites PTS and PTSO on various human tumor lines. These compounds have the ability to induce apoptosis and reduce the levels of pro-inflammatory cytokines, suggesting their promising role in cancer prevention and/or treatment.
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Article
Biochemistry & Molecular Biology
Maria Jesus Rodriguez-Sojo, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Jose Alberto Molina-Tijeras, Patricia Diez-Echave, Laura Lopez-Escanez, Lucrezia Rosati, Elena Gonzalez-Lozano, Laura Cenis-Cifuentes, Jorge Garcia-Garcia, Federico Garcia, Inaki Robles-Vera, Miguel Romero, Juan Duarte, Jose Luis Cenis, Antonio Abel Lozano-Perez, Julio Galvez, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales
Summary: Morus alba L. leaf extract has beneficial effects on high-fat diet-induced obesity in mice by reducing weight gain, attenuating lipid accumulation, increasing glucose sensitivity, and improving obesity-associated inflammation. These effects are possibly due to the extract's antioxidant properties. Moreover, the extract also mitigates gut dysbiosis, as evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide levels.
Article
Infectious Diseases
Jorge Garcia-Garcia, Patricia Diez-Echave, Maria Eugenia Yuste, Natalia Chueca, Federico Garcia, Jose Cabeza-Barrera, Emilio Fernandez-Varon, Julio Galvez, Manuel Colmenero, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales, Rocio Moron
Summary: The number of ICU patients and antibiotic treatments has increased due to SARS-CoV-2 infection, leading to a rise in multi-drug resistant bacteria (MDRB) colonization. As these bacteria mainly come from gut microbiota, studying its composition is crucial. This pilot study aims to identify bacteria biomarkers for predicting MDRB colonization risk in SARS-CoV-2 patients in ICUs.