Article
Immunology
Suyash Chavan, Proteesh Rana, Reva Tripathi, Uma Tekur
Summary: The study concluded that ferrous sulphate, iron hydroxide polymaltose complex, and ferrous ascorbate have comparable efficacy and safety profiles in the treatment of iron-deficiency anaemia during pregnancy. While ferrous ascorbate showed significantly higher haemoglobin levels compared to ferrous sulphate at day 90, overall the three groups showed similar levels of haemoglobin.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Helena Tiekou Lorinczova, Gulshanara Begum, Derek Renshaw, Mohammed Gulrez Zariwala
Summary: This study aimed to evaluate the influence of a formulated bioavailable form of curcumin on acute iron absorption and status, and the results showed that the formulated curcumin did not negatively impact acute iron absorption in healthy humans, regardless of the dose used.
Article
Gastroenterology & Hepatology
Jonathon Snook, Neeraj Bhala, Ian L. P. Beales, David Cannings, Chris Kightley, Robert Ph Logan, D. Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M. Verma, Andrew F. Goddard
Summary: Iron deficiency anaemia is a major global cause of disease burden, diagnosed through blood testing and treated with iron replacement therapy. Causes include poor diet and gastrointestinal pathologies, with endoscopy and radiological scanning used for diagnosis and assessment in some cases.
Article
Cardiac & Cardiovascular Systems
Lita Dwi Suryani, Sunu Budhi Raharjo, Rima Sagita, Hansen Angkasa, Yosafat Lambang Prasetyadi, Franciscus D. Suyatna, Nani Hersunarti, Rarsari Soerarso, Bambang Budi Siswanto, Hary Sakti Muliawan
Summary: This study demonstrates that oral ferrous sulphate supplementation significantly improves functional capacity in heart failure patients with iron deficiency anemia (IDA).
Article
Medicine, Research & Experimental
Bosede B. Afolabi, Ochuwa A. Babah, Opeyemi R. Akinajo, Victoria O. Adaramoye, Titilope A. Adeyemo, Mobolanle Balogun, Aduragbemi Banke-Thomas, Rachel A. Quao, Gbenga Olorunfemi, Ajibola Abioye, Hadiza S. Galadanci, Nadia A. Sam-Agudu
Summary: The IVON trial investigates the effectiveness and safety of intravenous ferric carboxymaltose versus oral ferrous sulphate for pregnancy-related iron deficiency anaemia (IDA) in Nigeria. It also measures the implementation outcomes of acceptability, feasibility, fidelity, and cost-effectiveness for intravenous ferric carboxymaltose. The trial aims to provide evidence for policy guidance on integrating intravenous iron for treating anaemia in pregnancy in resource-limited settings.
Article
Medicine, General & Internal
Nuredin I. Mohammed, James Wason, Thomas Mendy, Stefan A. Nass, Ogochukwu Ofordile, Famalang Camara, Bakary Baldeh, Chilel Sanyang, Amadou T. Jallow, Ilias Hossain, Nuno Faria, Jonathan J. Powell, Andrew M. Prentice, Dora I. A. Pereira
Summary: The IHAT-GUT trial assessed the efficacy and safety of a novel nano iron supplement, IHAT, for the treatment of iron deficiency anaemia (IDA) in children under 3 years of age. The study found that IHAT was non-inferior to standard-of-care FeSO4 in correcting iron deficiency and haemoglobin response. IHAT also had a lower incidence of moderate-severe diarrhoea compared to FeSO4.
Article
Oncology
Jie Jin, Zhihua Ran, Emanuele Noseda, Bernard Roubert, Matthieu Marty, Anna Mezzacasa, Udo Michael Goring
Summary: Ferric carboxymaltose (FCM) and iron sucrose (IS) have similar effects in treating iron deficiency anemia (IDA), but FCM shows a faster hemoglobin response and correction of iron deficiency.
FRONTIERS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Azrai Abu, Azniza Suriati Borhan, Abdul Kadir Abdul Karim, Mohd Faizal Ahmad, Zaleha Abdullah Mahdy
Summary: The study concluded that Zincofer (R) offers equivalent efficacy and side effect profile compared to Iberet Folic (R) for the treatment of iron deficiency anaemia (IDA) during pregnancy, but with lower cost.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2021)
Article
Gastroenterology & Hepatology
Jassin Rashidi-Alavijeh, Nargiz Nuruzade, Alexandra Frey, Eva-Maria Huessler, Anne Hoerster, Amos Cornelius Zeller, Andreas Schuette, Hartmut Schmidt, Katharina Willuweit, Christian Markus Lange
Summary: This study aimed to evaluate the role of iron supplementation in improving the prognosis of patients with cirrhosis. The results showed that an increase in hemoglobin levels was associated with improved transplant-free survival in patients with cirrhosis. The combination of iron supplementation and rifaximin had a stronger effect on prognosis.
Article
Biochemistry & Molecular Biology
Jamie A. O'Rourke, Michelle A. Graham
Summary: Yield loss due to abiotic stress is a growing problem in agriculture, especially for soybean crops in the upper Midwestern United States with calcareous soils. The soybean variety Fiskeby III has unique resistance to various abiotic stresses, including iron deficiency. Silencing a MATE transporter gene (Glyma.05G001700) in Fiskeby III confirmed its role in iron stress response and revealed new genes and pathways involved in Fiskeby III's ability to quickly respond to stress. Understanding and characterizing these genes and pathways provides potential targets for improving abiotic stress tolerance in elite soybean lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Reza Heidari, Seyedeh-Masoumeh Taghizadeh, Mahboubeh Karami-Darehnaranji, Esmaeil Mirzaei, Aydin Berenjian, Alireza Ebrahiminezhad
Summary: This study compared the bioavailability and biocompatibility of iron oxide-hydroxide (FeOOH) nanospheres (FeNSs) and nanorods (FeNRs) in an in vivo study, and found that nano-based iron supplements are more efficient than iron salts, with the shape of the nanostructures affecting their bioavailability.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Multidisciplinary Sciences
Shekhar Chauhan, Pradeep Kumar, Strong P. Marbaniang, Shobhit Srivastava, Ratna Patel
Summary: Anaemia in adolescents is associated with physical disorders, growth, and mental retardation, with higher prevalence among adolescent girls. This study fills a gap in anaemia intervention programs for adolescents by analyzing data from Uttar Pradesh and Bihar, India. The findings suggest that anaemia is more prevalent among rural adolescents, those with lower education levels, late adolescence, and those with no exposure to mass media. Effective public health policies targeting rural adolescents and disseminating information through mass media are needed to address anaemia in this population.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.
Review
Pediatrics
Sophie Jullien
Summary: There is currently no suitable non-invasive test with high accuracy for screening for IDA, and uncertainty exists regarding whether IDA in children under five years of age causes cognitive and psychomotor delays. There is a lack of evidence on the effects of routine screening for IDA in asymptomatic children under five years of age on growth, cognitive, and psychomotor development outcomes. Recommended by the American Academy of Paediatrics, selective screening of IDA is suggested in infants and children with risk factors such as prematurity, low birth weight, and dietary risks, contradicting the recommendations of other major organizations.
Article
Nutrition & Dietetics
Evasio Pasini, Giovanni Corsetti, Claudia Romano, Roberto Aquilani, Tiziano Scarabelli, Carol Chen-Scarabelli, Francesco S. Dioguardi
Summary: This article discusses the blood-related issues caused by chronic diseases and treatment strategies for anemia. Emphasis is placed on the need for not only iron supplementation, but also providing all precursor molecules necessary for heme synthesis. Research shows that in elderly anemic patients, implementing personalized treatment strategies including supplementation of essential amino acids and vitamins can lead to a faster increase in hemoglobin levels.