Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew B. Gill, Ferdia A. Gallagher, Martin J. Graves
Summary: Customized digital reference objects (DROs) were generated and used to validate the accuracy of kinetic model analysis software packages for dynamic contrast-enhanced MR images. The generated DROs were input into three different software packages and compared with the 'ground-truth' values, showing excellent agreement. This suggests that the DRO generation code can be used to validate other third party software for DCE-MRI data analysis.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ben R. Dickie, Zaki Ahmed, Jonathan Arvidsson, Laura C. Bell, David L. Buckley, Charlotte Debus, Andrey Fedorov, Ralf Floca, Ingomar Gutmann, Rianne A. van Der Heijden, Petra J. van Houdt, Steven Sourbron, Michael J. Thrippleton, Chad Quarles, Ina N. Kompan, Perfusion Study Grp ISMRM
Summary: This manuscript introduces the ISMRM OSIPI lexicon for dynamic contrast-enhanced and dynamic susceptibility-contrast MRI, which provides standardized definitions for commonly used quantities, models, and analysis processes. The lexicon was developed by Taskforce 4.2 of OSIPI and underwent open review before being endorsed by the Perfusion Study Group of the ISMRM. It aims to reduce reporting variability and increase reproducibility within the field of perfusion imaging.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stig P. Cramer, Henrik B. W. Larsson, Maria H. Knudsen, Helle J. Simonsen, Mark B. Vestergaard, Ulrich Lindberg
Summary: This study investigates the reproducibility of DCE-MRI in healthy controls and evaluates the impact of arterial input function selection and manual region of interests delineation versus automated global segmentation. The results show excellent reproducibility of pharmacokinetic variables derived from DCE-MRI in healthy controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Roberta Fusco, Vincenza Granata, Mauro Mattace Raso, Paolo Vallone, Alessandro Pasquale De Rosa, Claudio Siani, Maurizio Di Bonito, Antonella Petrillo, Mario Sansone
Summary: The study aimed to differentiate benign and malignant breast lesions by combining BOLD-MRI, DCE-MRI, and DW-MRI, but found that the combined use of these imaging techniques did not provide a significant improvement compared to using DCE-MRI alone. An interesting result was the negative correlation between R-2* and D.
Article
Multidisciplinary Sciences
Yi-Jui Liu, Hou-Ting Yang, Melissa Min-Szu Yao, Shao-Chieh Lin, Der-Yang Cho, Wu-Chung Shen, Chun-Jung Juan, Wing P. Chan
Summary: This study investigated the impact of AIF selection on vertebral perfusion quantification using DCE-MRI. Simulation results showed that decreasing peak in AIF increased K-trans and v(e), while increasing delay time in AIF increased v(p). In human subjects, K-trans and v(e) were significantly smaller with AIF_A compared to AIF_SA, while both parameters were significantly greater with AIF_SA compared to AIF_A.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Michelle Roytman, Sean Kim, Shannon Glynn, Charlene Thomas, Eaton Lin, Whitney Feltus, Rajiv S. Magge, Benjamin Liechty, Theodore H. Schwartz, Rohan Ramakrishna, Nicolas A. Karakatsanis, Susan C. Pannullo, Joseph R. Osborne, Jonathan P. S. Knisely, Jana Ivanidze
Summary: This study investigated the correlation between tumor vascularity and SSTR2 expression in meningiomas using Gallium-68-DOTATATE PET/MRI. The results showed a strong correlation between tumor vascularity and SSTR2 expression in WHO-2 and WHO-3 meningiomas, but not in WHO-1 meningiomas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harrison Kim, John Thomas, Jeffrey W. Nix, Jennifer B. Gordetsky, Yufeng Li, Soroush Rais-Bahrami
Summary: The study aimed to improve accuracy in quantitative dynamic contrast-enhanced magnetic resonance imaging measurement using a point-of-care portable perfusion phantom (P4) for better stratification of prostate cancer grade. After P4-based error correction, there were statistically significant differences in K-trans values among low, intermediate, and high-grade tumors. The results showed that P4 reduced errors in measurement and enhanced accuracy in grading prostate cancer.
ACADEMIC RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Eve S. Shalom, Amirul Khan, Sven Van Loo, Steven P. Sourbron
Summary: This review paper explores the spatiotemporal modeling of perfusion MRI, highlighting the limitations of current analysis methods and the potential of machine learning for new approaches.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Oncology
Shuncong Wang, Yuanbo Feng, Lei Chen, Jie Yu, Yue Li, Yicheng Ni
Summary: The role of the blood-brain barrier in intracranial cancer treatment with vascular-disrupting agents is not clear. This study used a craniofacial metastasis model to compare the vascular shutdown between intracranial and extracranial tumors using in vivo MRI imaging, postmortem NanoCT, and pathology analyses. The results showed that intracranial tumors had weaker vascular shutdown compared to extracranial tumors. In vivo multiparametric MRI may predict the efficacy of vascular-disrupting agents on craniofacial tumors.
Article
Engineering, Biomedical
Yajun Xu, Jianlin Lv, Na Shen, Zhaohui Tang, Xuesi Chen
Summary: In this study, researchers constructed a self-activating nanoized plinabulin that can be selectively activated by intrinsic tumor hypoxia to disrupt tumor vessels and inhibit tumor growth. The nanoized plinabulin demonstrated selective distribution in tumors and showed stronger anti-tumor effects compared to traditional plinabulin.
Article
Multidisciplinary Sciences
Woo Hyeon Lim, Joon Sik Park, Jaeseok Park, Seung Hong Choi
Summary: This study compared high-resolution DCE-MRI with conventional DCE-MRI in 30 consecutive patients suspected to have brain tumors. It was found that high-resolution DCE-MRI parameters showed better reproducibility and provided better quality of arterial input functions (AIFs) compared to conventional DCE-MRI.
SCIENTIFIC REPORTS
(2021)
Article
Thermodynamics
Ajay Bhandari, Siddhartha Mukharjee, Anand Kumar, Anup Singh, Wenbo Zhan
Summary: Radio-frequency ablation (RFA) is a minimally invasive treatment with limited clinical application. This study uses computational modeling to examine the effects of heterogeneous blood perfusion on RFA treatment. Results show that heterogeneous blood perfusion leads to deeper heat penetration in tumor tissue and increases tissue temperature and ablation volume. The ablation volume is highly susceptible to RF voltage and coolant temperature, which can be optimized for each patient to improve treatment efficacy.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Ka-Loh Li, Daniel Lewis, Xiaoping Zhu, David J. Coope, Ibrahim Djoukhadar, Andrew T. King, Timothy Cootes, Alan Jackson
Summary: This study developed a new DCE-MRI processing technique that combines LEGATOS with multi-kinetic models to evaluate tumor microvascular changes and predict antiangiogenic therapy response. The technique enables high spatial resolution interrogation of flow and permeability effects.
Article
Biochemistry & Molecular Biology
Jayanarayanan Sadanandan, Monica Sathyanesan, Yutong Liu, Neeraj K. Tiwari, Samuel S. Newton
Summary: Cerebral hypoperfusion has negative effects on cognitive function and increases the risk of neuropsychiatric disorders. Erythropoietin (EPO) has been shown to improve cognitive function, but its use is limited due to its erythropoietic activity. However, carbamoylated erythropoietin (CEPO), a non-erythropoietic derivative of EPO, has similar neurotrophic and behavioral effects without affecting hematocrit levels. Our study reveals that CEPO can increase blood perfusion through neurotransmission and vasodilation, without affecting tight junction integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. Padhani, Ivo Schoots, Geert Villeirs
Summary: The benefits and drawbacks of dynamic contrast-enhanced MRI for prostate cancer diagnosis are increasingly recognized, with many centers adopting the biparametric MRI approach as the default initial approach. However, more prospective data are needed to evaluate the efficacy and applicability of this approach.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ivo G. Schoots, Jelle O. Barentsz, Leonardo K. Bittencourt, Masoom A. Haider, Katarzyna J. Macura, Daniel J. A. Margolis, Caroline M. Moore, Aytekin Oto, Valeria Panebianco, Mohummad M. Siddiqui, Clare Tempany, Baris Turkbey, Geert M. Villeirs, Jeffrey C. Weinreb, Anwar R. Padhani
Summary: The increasing demand for diagnostic prostate MRI has raised concerns about access to qualified MRI equipment and experienced medical personnel. Solutions should aim to improve operational efficiency while maintaining diagnostic performance and quality. Strategies could involve implementing MRI without contrast medium or using a risk-based approach for protocol selection.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. Padhani, Ivo G. Schoots, Baris Turkbey, Gianluca Giannarini, Jelle O. Barentsz
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sandy Van Nieuwenhove, Julien Van Damme, Anwar R. Padhani, Vincent Vandecaveye, Bertrand Tombal, Joris Wuts, Vassiliki Pasoglou, Frederic E. Lecouvet
Summary: Over the past decade, advancements in updated definitions and therapies have remarkably changed the management of prostate cancer patients. Modern imaging techniques, including whole-body magnetic resonance imaging (WB-MRI) and nuclear medicine, provide accurate staging and evaluation of disease response to treatment. This paper discusses the evolution and current state-of-the-art of WB-MRI imaging protocols and highlights its applications in prostate cancer care.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Oncology
E. J. Bass, A. Pantovic, M. Connor, R. Gabe, A. R. Padhani, A. Rockall, H. Sokhi, H. Tam, M. Winkler, H. U. Ahmed
Summary: Biparametric MRI shows comparable diagnostic performance to multiparametric MRI in detecting prostate cancer, but heterogeneity exists which prevents definitive recommendations from being made. Prospective multicentre studies are needed to further assess the efficacy of biparametric MRI in biopsy naive men.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Oncology
Adham Hijab, Sebastian Curcean, Nina Tunariu, Holly Tovey, Roberto Alonzi, John Staffurth, Matthew Blackledge, Anwar Padhani, Alison Tree, Helen Stidwill, Jessica Finch, Peter Chatfield, Sophie Perry, Dow Mu Koh, Emma Hall, Chris Parker
Summary: Radium-223 combined with abiraterone and prednisolone increases the risk of fracture, while the fracture risk of radium-223 monotherapy is unclear. A prospective study found that men treated with radium-223 are at risk of fractures, especially in bones without metastases, and should receive bone health agents before treatment.
CLINICAL GENITOURINARY CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Petralia, Fabio Zugni, Paul E. Summers, Alberto Colombo, Paola Pricolo, Luigi Grazioli, Stefano Colagrande, Andrea Giovagnoni, Anwar R. Padhani
Summary: WB-MRI is recommended for cancer screening in individuals with cancer predisposition syndromes, as well as in asymptomatic subjects from the general population. The review focuses on analyzing acquisition protocols and synthesizing current recommendations regarding the use of WB-MRI for cancer screening.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tobias Penzkofer, Anwar R. Padhani, Baris Turkbey, Hashim U. Ahmed
EUROPEAN RADIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. Padhani, Masoom A. Haider, Olivier Rouviere
Summary: Before a prostate biopsy, balancing the benefits and harms of MRI results is important, as well as considering patients' preferences and tolerance. Decision curve analysis shows that combining clinical risk factors with MRI findings optimizes biopsy outcomes across a range of clinically relevant risk thresholds.
EUROPEAN RADIOLOGY
(2022)
Editorial Material
Urology & Nephrology
Anwar R. Padhani, Olivier Rouviere, Ivo G. Schoots
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Pecoraro, Baris Turkbey, Andrei S. Purysko, Rossano Girometti, Gianluca Giannarini, Geert Villeirs, Michela Roberto, Carlo Catalano, Anwar R. Padhani, Jelle O. Barentsz, Valeria Panebianco
Summary: This study aimed to evaluate the diagnostic accuracy of prostate imaging for recurrence reporting (PI-RR) in detecting local recurrence in patients with biochemical recurrence (BCR) after radiation therapy (RT) or radical prostatectomy (RP), as well as assess the interreader variability of PI-RR scoring. The results show that MRI scoring with PI-RR provides a structured, reproducible, and accurate evaluation of local recurrence after definitive therapy for prostate cancer.
Review
Urology & Nephrology
Tristan Barrett, Maarten de Rooij, Francesco Giganti, Clare Allen, Jelle O. Barentsz, Anwar R. Padhani
Summary: Multiparametric MRI of the prostate is recommended as the initial diagnostic test for suspected prostate cancer. Each step of the diagnostic pathway requires experienced clinicians and standardized workflows. Quality assurance processes and control measures are essential for the success of the MRI-directed prostate cancer diagnostic pathway.
NATURE REVIEWS UROLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. Padhani, Ivo G. Schoots
Article
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. R. Padhani, Ivo G. G. Schoots
Summary: This article comprehensively reviews the integration of MRI as a diagnostic tool in prostate cancer screening and provides practical recommendations for optimizing its use. To strike a balance between the benefits of early detection and minimizing harm, understanding the context of MRI use is crucial. Patient selection and MRI-targeted biopsies are key to optimization, along with screening-specific MRI protocols and accuracy levels. Automation, image quality monitoring, post-processing, radiologist certification, and deep-learning computer-aided software contribute to improved readings. The optimal utilization of MRI involves integrating it into a multi-step diagnostic pathway with quality-assured, cost-effective infrastructure ensuring community-wide access.
EUROPEAN RADIOLOGY
(2023)
Article
Urology & Nephrology
Ivo G. Schoots, Anwar R. Padhani