期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 39, 期 7, 页码 1068-1073出版社
WILEY-BLACKWELL
DOI: 10.1111/ejn.12500
关键词
synaptic physiology; psychiatric genetics; neurophysiology; synaptic plasticity; elecrtophysiology
资金
- Medical Research Council
- Pfizer
- Alzheimers Research UK [ARUK-SRF2012-6] Funding Source: researchfish
- Medical Research Council [984265] Funding Source: researchfish
The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.
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