Article
Biology
Rohini Bansal, Maximilian Nagel, Romana Stopkova, Yizhak Sofer, Tali Kimchi, Pavel Stopka, Marc Spehr, Yoram Ben-Shaul
Summary: Despite genetic variations, animals' olfactory systems are able to maintain stable representations of stimuli, providing a basis for common behaviors. Laboratory inbreeding does not always result in modifications that impact key ethological features related to wild animals.
Article
Biochemistry & Molecular Biology
Diogo Manoel, Melanie Makhlouf, Charles J. Arayata, Abbirami Sathappan, Sahar Da'as, Doua Abdelrahman, Senthil Selvaraj, Reem Hasnah, Joel D. Mainland, Richard C. Gerkin, Luis R. Saraiva
Summary: This study generated the most comprehensive mouse olfactory ethological atlas to date, revealing the diverse behavior of mice in response to different odorants. Three fundamental properties were identified in both mouse and human odor perception: odor valence parameters, physicochemical properties of odorants, and the impact of odorant concentration on olfactory perception. These results provide insights into mouse olfactory behavior and its comparison to human odor perception.
Article
Neurosciences
Kelsey E. Zuk, Hillary L. Cansler, Jinxin Wang, Julian P. Meeks
Summary: The accessory olfactory system (AOS) is crucial for social behavior development. In male and female mice, the accessory olfactory bulb (AOB) displays plasticity in response to social experience. Internal granule cells (IGCs) in the AOB express the immediate-early gene Arc after aggression or mating. This study investigates the role of Arc-expressing IGCs in the processing of territorial aggression. Results show that these IGCs become more excitable after resident-intruder interactions and play a significant role in ramping aggression exhibited by resident male mice.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
E. Altunisik, A. H. Baykan, S. Sahin, E. Aydin, S. M. Erturk
Summary: This study compared quantitative measurements of olfactory anatomic structures between patients diagnosed with COVID-19 associated with persistent olfactory dysfunction and healthy controls using MRI. The results showed significantly lower olfactory bulb volume, olfactory sulcus depth, and olfactory tract length in COVID-19 patients compared to healthy controls. MRI findings suggested olfactory injury in COVID-19 patients and the olfactory pathway may serve as an alternative route for virus entry into the central nervous system.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Neurosciences
Jan Weiss, Frank Zufall
Summary: This study demonstrates that GABA(B) receptors are expressed in the accessory olfactory bulb (AOB) and primarily located at vomeronasal nerve (VN) terminals. Activation of these receptors can modulate calcium influx and glutamate release of vomeronasal sensory neurons (VSNs), resulting in the regulation of synaptic transmission in the accessory olfactory system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Chase Amos, Michael A. Fox, Jianmin Su
Summary: The accessory olfactory bulb (AOB) in mammals receives input from vomeronasal sensory neurons (VSN) to detect pheromones and regulate the behaviors of animals of the same species. The molecular mechanism underlying the assembly of circuitry in the mouse AOB and the role of Collagen XIX in synaptogenesis were investigated in this study. The results showed that the loss of Collagen XIX led to defects in excitatory synapse distribution in the AOB and altered behavioral responses to pheromones in mutant mice.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Geoffrey Lie, Alexander Wilson, Thomas Campion, Ashok Adams
Summary: The olfactory pathway consists of both peripheral and central components, with various pathologies reflecting this complex relationship. Localizing olfactory pathology can be challenging for radiologists. This review demonstrates normal anatomy of the olfactory system and a systematic approach to evaluating olfactory dysfunction through image interpretation.
INSIGHTS INTO IMAGING
(2021)
Article
Neurosciences
Tal Inbar, Rachel Davis, Joseph F. Bergan
Summary: The study identified two new sources of aromatase signaling in the AOB, one being neurons within the AOB itself and the other being axons originating from the ventral MEA. A population of neurons in the ventral MEA provides significant feedback by aromatase-expressing neurons to the AOB, showing anatomical sex differences.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Santiago Estrada, Ran Lu, Kersten Diers, Weiyi Zeng, Philipp Ehses, Tony Stoecker, Monique M. B. Breteler, Martin Reuter
Summary: The neuroimage analysis community has historically neglected automated segmentation of the olfactory bulb, but recent advances in technology and deep learning methods have made reliable manual annotations possible. This study introduces a fast, automated deep learning pipeline for accurately segmenting olfactory bulb tissue on MRI images, showcasing high performance and applicability across different datasets and age ranges.
Article
Multidisciplinary Sciences
Hamna Haq Chouhdry, Dong Hyun Lee, Atanu Bag, Nae-Eung Lee
Summary: Developing an artificial olfactory system that can mimic biological functions is challenging. The authors developed an artificial chemosensory synapse using a flexible organic electrochemical transistor gated by the potential generated from gas molecules interacting with ions in a chemoreceptive ionogel. This device can sense chemical stimuli and mimic the functions of neurotransmitter release in the olfactory system, and has potential applications in biomimetic chemosensory systems.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Dmitriy Desser, Francisca Assuncao, Xiaoguang Yan, Victor Alves, Henrique M. Fernandes, Thomas Hummel
Summary: This study introduces a novel unbiased method for measuring olfactory bulb (OB) volume through a fully automated tool, which replaces the time-consuming and rater-biased manual segmentation process, enabling more fair and reliable comparisons in research. By utilizing multiple datasets, this method has successfully achieved accurate and rapid segmentation of OB, almost matching the accuracy of manual segmentations.
Article
Agriculture, Dairy & Animal Science
Mateo Torres, Irene Ortiz-Leal, Andrea Ferreiro, Jose Luis Rois, Pablo Sanchez-Quinteiro
Summary: Chemical senses play a crucial role in the survival of wild mammals. This study focuses on the neuroanatomical basis of the olfactory and accessory olfactory bulbs in meerkats. The results suggest that meerkats have a well-defined accessory olfactory bulb lamination pattern and a comparable level of development in the main olfactory bulb compared to other mammals. This study supports the functionality of the olfactory and vomeronasal integrative centers in meerkats and provides important information for understanding their chemical senses.
Article
Neurosciences
Sandeep K. Mishra, Mahendra Hidau
Summary: The study demonstrated that intranasal insulin treatment increased olfactory discriminative learning in the ICV STZ rat model by reversing the decline in SVZ-OB neurogenesis. However, there was no significant impact on olfactory memory post-treatment with ICV STZ and intranasal insulin.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie
Summary: This study reveals a direct relationship between nigral dopaminergic neurodegeneration and olfactory dysfunction in Parkinson's disease (PD) models. It suggests that olfactory dysfunction may represent an early sign of neurodegeneration in PD progression.
CELL DEATH DISCOVERY
(2023)
Review
Immunology
Brandon J. J. LaFever, Fumiaki Imamura
Summary: Nasal inflammation can cause damage to olfactory mucosal cells, leading to impaired olfactory function and structural and functional changes in the rodent olfactory bulb.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Endocrinology & Metabolism
Hugo Salais-Lopez, Maria Abellan-Alvaro, Maria Belles, Enrique Lanuza, Carmen Agustin-Pavon, Fernando Martinez-Garcia
Summary: Motherhood involves increased motivation for pups, which is influenced by steroids and lactogens acting on the female brain during pregnancy and postpartum. The acquisition of maternal motivation is related to prolactin (PRL) and stimuli derived from pups and their mother. Mothers showed higher PRL responsiveness, supporting the mechanism underlying maternal sensitization, while foster mothers also displayed enhancement, indicating an induced sensitization process.
NEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David Fabregat-Safont, Manuela Barneo-Munoz, Xoan Carbon, Felix Hernandez, Ferran Martinez-Garcia, Mireia Ventura, Christophe P. Stove, Juan Sancho, Maria Ibanez
Summary: This study reveals a direct relationship between the polarity of cathinone compounds and their concentration in telencephalon tissue. The permeability of cathinones through the blood-brain barrier is affected by the chemical moieties present in the compounds, with cathinones featuring longer alkyl chains or aromatic rings functionalized with alkyl moieties having lower concentrations in telencephalon tissue.
Correction
Behavioral Sciences
Ana Martin-Sanchez, Guillermo Valera-Marin, Adoracion Hernandez-Martinez, Enrique Lanuza, Fernando Martinez-Garcia, Carmen Agustin-Pavon
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Maria Abellan-Alvaro, Guillermo Ayala, Manuela Barneo-Munoz, Fernando Martinez-Garcia, Carmen Agustin-Pavon, Enrique Lanuza
Summary: The study reveals significant differences in gene expression between lactating females expressing maternal aggression and pup-sensitized virgin females, with upregulation of genes encoding hormones and neuropeptides in dams, and downregulation of genes encoding inhibins and transcription factors. Gene set analysis also shows higher expression of Gene Ontology functional groups related to the Jak/Stat cascade in dams. Additionally, olfactory and vomeronasal receptor genes are expressed in the medial amygdala without differences between dams and virgins.
Article
Multidisciplinary Sciences
Cinta Navarro-Moreno, Manuela Barneo-Munoz, Maria Victoria Ibanez-Gual, Enrique Lanuza, Carmen Agustin-Pavon, Maria Jose Sanchez-Catalan, Fernando Martinez-Garcia
Summary: Hormones during pregnancy increase motivated pup-directed behaviors. Pregnancy alters brain activity, increasing pup-induced activity in the motivation circuitry and reducing interest in buttons.
Article
Anatomy & Morphology
Cecilia Pardo-Bellver, Manuel E. Vila-Martin, Sergio Martinez-Bellver, Maria Villafranca-Faus, Anna Teruel-Sanchis, Camila A. Savarelli-Balsamo, Sylwia M. Drabik, Joana Martinez-Ricos, Ana Cervera-Ferri, Fernando Martinez-Garcia, Enrique Lanuza, Vicent Teruel-Marti
Summary: This study investigates the integration of chemosensory information in rodents, specifically the olfactory and vomeronasal systems. The results suggest that the amygdala plays a crucial role in controlling the activity of the olfactory bulbs, highlighting its active involvement in the integration of chemosensory information.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Behavioral Sciences
Jose Vicente Torres-Perez, Elena Martinez-Rodriguez, Anabel Forte, Carlos Blanco-Gomez, Oliver Stork, Enrique Lanuza, Monica Santos, Carmen Agustin-Pavon
Summary: This study finds that maternal separation exacerbates phenotypical alterations associated with lack of MeCP2 in adolescent males.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biology
Maria Abellan-Alvaro, Fernando Martinez-Garcia, Enrique Lanuza, Carmen Agustin-Pavon
Summary: Repeated testing affects aggression in postpartum mice, with dams showing escalated aggression and virgins showing no aggression. The medial amygdala plays a key role in the expression of escalated aggression induced by repeated testing.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Analytical
Leticia Lacalle-Bergeron, Rafael Goterris-Cerisuelo, Joaquin Beltran, Juan Vicente Sancho, Cinta Navarro-Moreno, Fernando Martinezq-Garcia, Tania Portoles
Summary: This study aimed to determine the low-volatile chemosignals excreted or secreted by mouse pups in their early days of life, which are involved in maternal care induction in adult female mice. Untargeted metabolomics was used to differentiate samples collected from the facial and anogenital area of neonatal mouse pups receiving maternal care and elder mouse pups in the weaning period. The results showed the potential of UHPLC-IMS-HRMS based untargeted metabolomics in identifying putative pheromones in mammals.
Article
Clinical Neurology
Vincent Planche, Jose Manjon, Boris Mansencal, Enrique Lanuza, Thomas Tourdias, Gwenaelle Catheline, Pierrick Coupe
Summary: This study used large-scale databases and MRI data to depict the progression stages of Alzheimer's disease in brain structures and found differences between the staging of tau pathology, suggesting involvement of other associated proteins and axonal degeneration.
BRAIN COMMUNICATIONS
(2022)