Review
Behavioral Sciences
Anil Joshi, Marion Schott, Susanne Eva la Fleur, Michel Barrot
Summary: Food intake is a necessary behavior for all animals, but excessive consumption of fat and sugar can lead to obesity. This review provides insights into the impact of food intake on the striatal complex and the modulation of palatable food intake by different neurochemical systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Soroush Darvish-Ghane, Jennet Baumbach, Loren J. Martin
Summary: Dopamine inhibits excitatory synaptic transmission in the ACC, but the modulation of inhibitory synaptic transmission and the E/I balance has been understudied. This study used patch-clamp recordings and found that DA did not significantly impact eEPSCs in the ACC. However, individual neurons showed varied responses to DA. The study suggests that CFA-induced inflammation and DA do not significantly affect the excitatory/inhibitory balance in ACC neurons. Evaluation: 6/10
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yuxiao Mei, Qi-Wei Zhang, Qingyi Gu, Zhichao Liu, Xiao He, Yang Tian
Summary: This article describes a new supramolecular fluorescent probe that efficiently identifies largescale neurotransmitters and enables high-throughput analysis using principal component analysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Cell Biology
Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle Hook, Yun Huang, Emmanuel Darcq, Jun Wang
Summary: Withdrawal from chronic opioid use leads to hypodopaminergic states and negative affect, promoting relapse. Activation of MORs in dMSNs in the striatal patch compartment suppresses striatopallidal transmission, and withdrawal potentiated this transmission. Fentanyl self-administration enhances striatonigral transmission and reduces dopaminergic activity, while activated striatal neurons mediate contextual memory retrieval. Inhibition of striatal MOR+ neurons rescues fentanyl withdrawal-induced physical symptoms and anxiety-like behaviors. These findings suggest that chronic opioid use induces GABAergic striatopallidal and striatonigral plasticity, leading to hypodopaminergic states and relapse.
Article
Biochemistry & Molecular Biology
Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wang
Summary: This study presents a topographical distribution map of dopamine, GABA, and glutamate neurons in the ventral tegmental area of mice. The majority of neurons expressed a single type of mRNA, while a subset of neurons co-expressed two or three molecular characteristics. These different neuronal populations were distributed differently across sub-nuclei in the ventral tegmental area, suggesting a complex organization of neuronal molecular characteristics and potentially diverse functions.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Daniel J. Foster, Zoey K. Bryant, P. Jeffrey Conn
Summary: Targeting specific muscarinic acetylcholine receptor subtypes may provide more comprehensive symptomatic relief for schizophrenia patients. Studies show that M1, M4, and M5 receptor subtypes modulate brain circuits and physiology underlying positive, negative, and cognitive symptoms of schizophrenia.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Lin Zhang, Deirdre M. McCarthy, Karen L. Eskow Jaunarajs, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
Summary: The study indicates that the KOR antagonist norbinaltorphimine (norBNI) and methylphenidate can improve attention and working memory in the PNE mouse model by increasing dopamine and noradrenaline release.
Article
Biochemistry & Molecular Biology
Yasumi Ohta, Takaaki E. Murakami, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta, Metin Akay, Yasemin M. Akay
Summary: This study confirms the importance of dopamine in reward behavior, as well as the interaction between dopaminergic and GABAergic neurons. The researchers used optogenetics to stimulate neurons in mice and measured dopamine release. The results show that different stimulation frequencies have different effects on dopamine release, and GABAergic neurons have an inhibitory effect on dopamine activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Archana Venkataraman, Sarah C. Hunter, Maria Dhinojwala, Diana Ghebrezadik, JiDong Guo, Kiyoshi Inoue, Larry J. Young, Brian George Dias
Summary: Fear generalization and deficits in extinction learning are major aspects of PTSD. Studies suggest that the zona incerta and thalamic reuniens may play a role in modulating fear processes. Optogenetic stimulation of GABAergic ZI -> RE cell terminals can reduce fear generalization and enhance extinction recall.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Binghan Xue, Jason B. Alipio, Joseph P. Y. Kao, Patrick O. Kanold
Summary: This study investigates the functional effects of perinatal fentanyl exposure on the auditory cortex. Results show that perinatal fentanyl exposure leads to decreased excitatory functional circuits and altered population activity in primary sensory areas in adult mice. These circuit changes may contribute to the observed language and cognitive deficits in infants exposed to opioids.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Tadashi Saigusa, Yuri Aono, John L. Waddington
Summary: The nucleus accumbens (NAc) is a terminal region for dopamine projections from the ventral tegmental area, regulated by interneurons and afferents from other brain regions. The relative roles of receptor subtypes in regulating NAc dopamine release are not well understood, with complex interactions involving opioid and GABA receptors.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biology
Alexander Soutschek, Susanna C. Weber, Thorsten Kahnt, Boris B. Quednow, Philippe N. Tobler
Summary: The study found that pharmacological manipulations can affect human desires for rewards rather than preferences, with stronger neural connectivity. Opioid receptors impact reward motivation, whereas dopamine receptors do not affect behavior or neural activity.
Article
Biochemistry & Molecular Biology
Josh Neuman, Nicole Roeder, Brittany Richardson, Teresa Quattrin, John Hamilton, Panayotis K. Thanos
Summary: The expression of the dopamine D2 gene plays a prominent role in the impact of a high-fat diet on GABA(A) receptors in the mouse brain.
NEUROCHEMICAL RESEARCH
(2022)
Review
Behavioral Sciences
Salar Vaseghi, Mohammad Nasehi, Mohammad-Reza Zarrindast
Summary: Cannabinoids interact with multiple neurotransmitters in learning and memory, yielding unpredictable effects, with mechanisms that require further investigation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biology
Charles Ducrot, Gregory de Carvalho, Benoit Delignat-Lavaud, Constantin V. L. Delmas, Priyabrata Halder, Nicolas Giguere, Consiglia Pacelli, Sriparna Mukherjee, Marie-Josee Bourque, Martin Parent, Lulu Y. Chen, Louis-Eric Trudeau
Summary: Midbrain dopamine (DA) neurons play a crucial role in regulating basal ganglia functions, and their connectivity and neurotransmission are influenced by neuroligins, particularly their interaction with neurexins. This study investigated the role of neurexins in DA neuron neurotransmission and found that mice lacking neurexins in DA neurons exhibited impaired locomotor response to amphetamine, decreased levels of DAT, increased levels of VMAT2, and reduced activity-dependent DA release. Electrophysiological recordings also revealed increased GABA co-release from DA neuron axons in these mice.