Article
Neurosciences
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson, Todd D. Gould
Summary: Ketamine, a well-known NMDA receptor antagonist, exerts rapid antidepressant effects by enhancing excitatory synaptic strength. These findings suggest that promoting NMDA receptor activation or enhancing NMDA receptor-dependent synaptic potentiation may be an effective strategy for antidepressant treatment.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Joseph A. McQuail, Sofia Beas, Kyle B. Kelly, Caesar M. Hernandez, Jennifer L. Bizon, Charles J. Frazier
Summary: The study revealed that loss of NMDARs on interneurons in the PFC contributes to age-related impairment of cognitive flexibility, while a clear increase in AMPA/NMDA ratio in FSIs suggests a potential underlying mechanism for cognitive decline. These findings provide new insights into the neural mechanisms of cognitive decline.
Review
Biochemistry & Molecular Biology
Guendalina Olivero, Alessandra Roggeri, Anna Pittaluga
Summary: Autoantibodies against NMDA and AMPA receptors in the central nervous system can lead to neurological and psychiatric symptoms and disrupt synaptic communication. Understanding the molecular mechanisms involved in these autoantibody-mediated effects is crucial for understanding their pathogenic role in central disorders and developing new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Sehoon Won, Katherine W. Roche
Summary: Phosphorylation regulates glutamate receptor trafficking and plays a key role in synaptic transmission and plasticity. The protein tyrosine phosphatase STEP61 is involved in differentially regulating NMDARs and AMPARs, and has been implicated in various neurological disorders. Its interplay with Fyn and GluN2B-containing NMDARs has been extensively studied, demonstrating its importance in synaptic function.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
S. Murat Durakoglugil, R. Catherine Wasser, H. Connie Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz
Summary: Alzheimer's disease is characterized by the accumulation of Aβ plaques and neurofibrillary tangles, leading to synaptic dysfunction. Reelin protects synapses against Aβ toxicity through ApoE receptors. Experiments showed that Reelin modulates mGluR-LTD, potentially impacting memory consolidation or neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sighild Lemarchant, Melissa Sourioux, Juliette Le Douce, Alexandre Henriques, Noelle Callizot, Sandrine Hugues, Melissa Farinelli, Yann Godfrin
Summary: NX210c enhances excitatory synaptic currents and synaptic transmission in the brain, leading to improved memory. By modulating synaptic transmission and signaling, NX210c presents an innovative therapeutic opportunity for neurological disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yao Q. Wang, Yanhua H. Huang, Saju Balakrishnan, Lidong Liu, Yu Tian Wang, Eric J. Nestler, Oliver M. Schluter, Yan Dong
Summary: This study elucidates the dynamic interactions between AMPARs and NMDARs during the generation and maturation of silent synapses in the NAc after cocaine experience. The findings provide a mechanistic basis for manipulating new synaptic contacts and potentially new neural network patterns created by these synapses for therapeutic benefit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Amit Kumar, Edi Barkai, Jackie Schiller
Summary: Contrary to previous beliefs, this study found that synaptic plasticity in LOT synapses is stronger and more robust than in IC synapses when receiving specific stimulation, suggesting a self-potentiating mechanism for odor information via NMDA-spikes. Additionally, association between olfactory and contextual information through STDP mechanisms provides cognitive and emotional value to odors.
Article
Biochemistry & Molecular Biology
Maxim Nikolaev, Daniil M. Strashkov, Mikhail N. Ryazantsev, Denis B. Tikhonov
Summary: Azobenzene-based quaternary ammonium compounds provide optical control of ion channels and affect glutamatergic transmission and synaptic plasticity in rat brain neurons. The light-induced transformation of DENAQ and DMNAQ to their cis forms increases their inhibitory effect on NMDA receptors. The action of these compounds involves a complex nature consisting of fast inhibitory and slower potentiating effects.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Physiology
Roger A. Nicoll, Howard Schulman
Summary: This article reviews the relationship between CaMKII and LTP, as well as the role of new technologies in research. It proposes a model for synaptic memory and discusses the steps involved in driving this process, along with the supporting evidence for each step. Despite the lengthy research journey, the prospect of a cellular and molecular understanding of learning and memory is within reach.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Yurika Hata, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Hideaki Ono, Takaaki Aratake, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: This study investigated the effects of central CRF on micturition and the involvement of CRF receptor subtypes and glutamatergic receptors. The results suggest that stimulation of brain CRFR1 may facilitate rat micturition via brain NMDA/AMPA receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Jian-Shun Zhou, Guan-Fa Peng, Wei-Dong Liang, Zhen Chen, Ying-Ying Liu, Bing-Yu Wang, Ming-Ling Guo, Yun-Ling Deng, Jun-Ming Ye, Mao-Lin Zhong, Li-Feng Wang
Summary: This paper reviews the mechanisms of action of S-ketamine on relevant receptors and systems in the body, exploring the pathways that result in its pharmacological properties such as anesthesia and analgesia.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jenni Harvey
Summary: It has been well established that leptin plays a crucial role in controlling energy homeostasis by signaling to specific hypothalamic nuclei. However, recent studies have revealed that leptin also acts on hippocampal synapses and significantly impacts cognitive processes, particularly hippocampal-dependent learning and memory.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Chen Tian, Jeremiah D. Paskus, Erin Fingleton, Katherine W. Roche, Bruce E. Herring
Summary: The study identified that mutations in the Trio protein can affect its interaction with Neuroligin 1, leading to disrupted synaptogenesis and aberrant glutamatergic neurotransmission. These mutations not only increase synaptogenesis, but may also decrease the effects of NLGN-mediated glutamatergic neurotransmission.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Jolanta Strzelecka, Dariusz Wojciech Mazurkiewicz, Tymon Skadorwa, Jakub S. Gasior, Sergiusz Jozwiak
Summary: This study provides an overview of the literature on photo-dependent reflex seizures and differentiates between various types of reflex seizures. Differentiating between these types of seizures is crucial for determining the appropriate duration of treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)