Article
Biochemistry & Molecular Biology
Valeska Cid-Jofre, Macarena Moreno, Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M. Renard
Summary: This study aimed to evaluate the effects of chronic MOD treatment on neurochemicals, dopamine receptor 2 expression, and behavior in the mesocorticolimbic system of young healthy rats. The results showed that chronic use of MOD during adolescence induces behavioral and neurochemical changes associated with the mesocorticolimbic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Zhi Fei Li, Sandrine Chometton, Genevieve Guevremont, Elena Timofeeva, Igor Timofeev
Summary: This study observed compulsive eating in stress-induced binge-like eating rats, showing that binge-like eating prone rats had high sucrose intake and inhibited fear response, indicating deficits in palatability devaluation and anxiolytic response to sucrose. Neuronal activation analysis revealed that sucrose did not inhibit amygdala activity but activated central amygdala. Sucrose reduced responses in the paraventricular hypothalamic nucleus and enhanced activities in the lateral hypothalamic area in BEPs.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M. M. Verheij, Fabio Fumagalli, Judith R. Homberg
Summary: This study investigates the influence of SERT deletion on glutamate homeostasis in the NAc, and finds that SERT deletion leads to a reduction in glutamate signaling and further dysregulation in the glutamatergic synapse after cocaine self-administration.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Shiou-Shiow Farn, Kai-Hung Cheng, Yuan-Ruei Huang, Shih-Ying Lee, Jenn-Tzong Chen, Kang-Wei Chang
Summary: Clinical studies have found that the GABA(A) receptor complex plays a crucial role in anxiety modulation. This study successfully synthesized high-purity [F-18]flumazenil using a nucleophilic fluorination method and explored the distribution of GABA(A) receptors in fear-conditioned rats through PET and autoradiography. The results showed a significantly lower accumulation of fear conditioning in anxiety rats in specific brain regions (amygdala, prefrontal cortex, cortex, and hippocampus). This study provides a useful reference method for future research on GABA(A)/BZR receptor drugs.
Article
Audiology & Speech-Language Pathology
Donald A. Godfrey, William B. Farms, Sharon Polensek, Jon D. Dunn, Timothy G. Godfrey
Summary: The study showed that disrupting the pathways from the brain stem to the cochlear nucleus led to reduced levels of GABA, aspartate, and glutamate, indicating their quantitative contributions as neurotransmitters. GABAergic pathways play a crucial role in the cochlear nucleus, and lesioning specific pathways had varying effects on amino acid levels.
Article
Neurosciences
Viktoria S. Pendeliuk, Igor V. Melnick
Summary: Synchronization of hippocampal interneurons (INs) relies on local cell interactions and intensity of network activity. In baseline conditions, a significant portion of inhibitory postsynaptic currents coincided between cells. Network activity induced excitatory and inhibitory events, with excitatory events capable of synchronizing IN firing. Glutamatergic mechanisms play a crucial role in initiating and dominating IN synchronization.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Robert A. Phillips, Jennifer J. Tuscher, Samantha L. Black, Emma Andraka, N. Dalton Fitzgerald, Lara Ianov, Jeremy J. Day
Summary: This study comprehensively defines the molecular architecture of the ventral tegmental area (VTA) by performing single-nucleus RNA sequencing on rat VTA cells. It identifies selective markers for dopamine and combinatorial neurons, reveals expression profiles for drug receptors, and demonstrates population-specific enrichment of gene sets linked to brain disorders.
Article
Biochemistry & Molecular Biology
Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang
Summary: ISL inhibits glutamate release by reducing intracellular [Ca2+] increase and suppressing PKC phosphorylation through activation of GABA(B) receptors and G(βγ)-coupled inhibition of P/Q-type Ca2+ channels in rat cerebrocortical nerve terminals.
Article
Clinical Neurology
Dana Marafi, Jawid M. Fatih, Rauan Kaiyrzhanov, Matteo P. Ferla, Charul Gijavanekar, Aljazi Al-Maraghi, Ning Liu, Emily Sites, Hessa S. Alsaif, Mohammad Al-Owain, Mohamed Zakkariah, Ehab El-Anany, Ulviyya Guliyeva, Sughra Guliyeva, Colette Gaba, Ateeq Haseeb, Amal M. Alhashem, Enam Danish, Vasiliki Karageorgou, Christian Beetz, Alaa A. Subhi, Sureni Mullegama, Erin Torti, Monisha Sebastin, Margo Sheck Breilyn, Susan Duberstein, Mohamed S. Abdel-Hamid, Tadahiro Mitani, Haowei Du, Jill A. Rosenfeld, Shalini N. Jhangiani, Zeynep Coban Akdemir, Richard A. Gibbs, Jenny C. Taylor, Khalid A. Fakhro, Jill Hunter, Davut Pehlivan, Maha S. Zaki, Joseph G. Gleeson, Reza Maroofian, Henry Houlden, Jennifer E. Posey, V. Reid Sutton, Fowzan S. Alkuraya, Sarah H. Elsea, James R. Lupski
Summary: SLC38A3 is a novel disease gene for developmental and epileptic encephalopathy, and the likely pathophysiology of the disease is perturbations in glutamine homeostasis.
Article
Neurosciences
Dillon J. McGovern, Abigail M. Polter, David H. Root
Summary: Glutamate and GABA are the main excitatory and inhibitory neurotransmitters of the nervous system, with distinct inputs to VTA glutamate neurons participating in reward and aversion-based behaviors. Through the use of genetically-encoded fluorescent indicators, the study identified differential and dynamic signaling of glutamate and GABA inputs to VTA glutamate neurons in response to reward and aversion cues and outcomes, shedding light on the neurochemical mechanisms underlying motivated behaviors. The research provides foundational evidence linking specific neurotransmitters to the regulation of motivated behaviors by VTA glutamate neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Lei Han, Kenneth Lap-Kei Wu, Pui-Yi Kwan, Oscar Wing-Ho Chua, Daisy Kwok-Yan Shum, Ying-Shing Chan
Summary: Chemogenetic activation of 5-HT neurons projecting to the medial vestibular nucleus led to deficits in vestibular-related tasks in rats. The effects were mediated by the 5-HT1A receptor and were attenuated through a presynaptic mechanism in the vestibular nucleus. These results highlight the role of the 5-HT1A receptor as a gain controller in vestibular-related brainstem circuits for posture and balance.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Zuzanna Szych, Iwona Majcher-Maslanka, Monika Herian, Marzena Mackowiak, Krystyna Golembiowska
Summary: Clinical studies suggest that ketamine and psilocybin may have potential as fast-acting antidepressants. This study used microdialysis to investigate the effect of these drugs on neurotransmitter levels in rat brain regions. The findings showed that both ketamine and psilocybin affected neurotransmitter levels, but did not significantly alter animal behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Minglong Zhang, Yixiao Luo, Jian Wang, Yufei Sun, Bing Xie, Ludi Zhang, Bin Cong, Chunling Ma, Di Wen
Summary: This study found that traumatic memory decreases the expression of SK3 channels in NAcS, leading to increased excitability of NAcS neurons and enhanced consolidation of conditioned fear. Overexpressing SK3 channels in NAcS can block fear conditioning-induced changes in neuronal excitability and mAHP amplitude, suggesting its potential as a therapeutic target against PTSD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Cell Biology
Sina Hafizi, Tarek K. Rajji
Summary: This review proposes a conceptual model that links 12 potentially modifiable risk factors for dementia with Excitation-Inhibition (E -I) imbalance. The model aims to address the current knowledge gap and provides a framework for future studies in dementia prevention, discovery of new biomarkers, and development of new interventions.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Andrew D. Chapp, Paul G. Mermelstein, Mark J. Thomas
Summary: The study suggests that acetic acid may play a role in neurophysiological changes in medium spiny neurons of the nucleus accumbens, potentially influencing behaviors and physiological responses associated with ethanol consumption. This raises the interesting possibility that ethanol may act as a prodrug generating acetic acid as a metabolite, altering neurophysiological function to influence behaviors and physiological responses related to ethanol consumption.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Hammad A. Khan, Kevin R. Urstadt, Nina A. Mostovoi, Kent C. Berridge
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Kevin R. Urstadt, Kent C. Berridge
Article
Neurosciences
David J. Ottenheimer, Bilal A. Bari, Elissa Sutlief, Kurt M. Fraser, Tabitha H. Kim, Jocelyn M. Richard, Jeremiah Y. Cohen, Patricia H. Janak
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Hannah M. Baumgartner, Jay Schulkin, Kent C. Berridge
Summary: Activation of CRF neurons in the CeA and NAc enhances incentive motivation and promotes reward pursuit and consumption, while activation of CRF neurons in the BNST produces negative valence and aversive effects, suppressing the pursuit and consumption of rewards.
BIOLOGICAL PSYCHIATRY
(2021)
Editorial Material
Neurosciences
Kent C. Berridge
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Shelley M. Warlow, Kent C. Berridge
Summary: The central nucleus of amygdala (CeA) plays a role in mediating both positively-valenced reward motivation and negatively-valenced fear. Stimulation of CeA circuitry can intensify incentive motivation while not affecting hedonic impact of the reward. CeA can promote either incentive motivation or fearful motivation, potentially leading to different outcomes in neuropsychiatric disorders involving aberrant motivational salience.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Editorial Material
Neurosciences
Brian A. Baldo, Kent C. Berridge
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Biological
Daniel Dukes, Kathryn Abrams, Ralph Adolphs, Mohammed E. Ahmed, Andrew Beatty, Kent C. Berridge, Susan Broomhall, Tobias Brosch, Joseph J. Campos, Zanna Clay, Fabrice Clement, William A. Cunningham, Antonio Damasio, Hanna Damasio, Justin D'Arms, Jane W. Davidson, Beatrice de Gelder, Julien Deonna, Ronnie de Sousa, Paul Ekman, Phoebe C. Ellsworth, Ernst Fehr, Agneta Fischer, Ad Foolen, Ute Frevert, Didier Grandjean, Jonathan Gratch, Leslie Greenberg, Patricia Greenspan, James J. Gross, Eran Halperin, Arvid Kappas, Dacher Keltner, Brian Knutson, David Konstan, Mariska E. Kret, Joseph E. LeDoux, Jennifer S. Lerner, Robert W. Levenson, George Loewenstein, Antony S. R. Manstead, Terry A. Maroney, Agnes Moors, Paula Niedenthal, Brian Parkinson, Ioannis Pavlidis, Catherine Pelachaud, Seth D. Pollak, Gilles Pourtois, Birgitt Roettger-Roessler, James A. Russell, Disa Sauter, Andrea Scarantino, Klaus R. Scherer, Peter Stearns, Jan E. Stets, Christine Tappolet, Fabrice Teroni, Jeanne Tsai, Jonathan Turner, Carien Van Reekum, Patrik Vuilleumier, Tim Wharton, David Sander
Summary: Research has shown the significant impact of affective processes on human thinking and behavior, raising the question of whether this has led to a new era of affectivism.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Behavioral Sciences
David Nguyen, Erin E. Naffziger, Kent C. Berridge
Summary: The positive impact of rewards, which involve components of pleasure, motivation, and learning, is essential for well-being. Under normal conditions, liking and wanting are coherent, but alterations in neural signaling can lead to their dissociation, which may be detrimental to positive well-being.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kent C. Berridge, Peter Dayan
Article
Neurosciences
M. J. Carpio, Runbo Gao, Erica Wooner, Christelle A. Cayton, Jocelyn M. Richard
Summary: This study assessed the impact of CIE on cue-elicited alcohol seeking, finding that CIE enhanced responses to cues paired with alcohol, but only in rats with alcohol experience during acute withdrawal. CIE also influenced cue responses and likelihood of entering the alcohol port, even when rats had received alcohol during acute withdrawal.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Anne Armstrong, Hailey Rosenthal, Nakura Stout, Jocelyn M. Richard
Summary: This study aimed to test the impact of stress on behavioral responses to alcohol-paired cues using a model inspired by Nadia Chaudhri's work on context-induced reinstatement.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Alexandra Scott, Dakota Palmer, Bailey Newell, Iris Lin, Christelle A. Cayton, Anika Paulson, Paige Remde, Jocelyn M. Richard
Summary: Reward-seeking behavior can be triggered by environmental cues. However, excessive cue reactivity and reward-seeking behavior can be maladaptive. This study investigates the neural circuits involved in assigning value to rewarding cues and actions, focusing on ventral pallidum (VP) neurons. The findings suggest that VP GABA neurons encode reward expectation and their calcium activity reflects the intensity of cue-elicited reward seeking.
JOURNAL OF NEUROSCIENCE
(2023)
Meeting Abstract
Neurosciences
Kent Berridge
BIOLOGICAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
David J. Ottenheimer, Karen Wang, Xiao Tong, Kurt M. Fraser, Jocelyn M. Richard, Patricia H. Janak