Review
Biochemistry & Molecular Biology
Zhenglin Gu, Jerrel L. Yakel
Summary: Cholinergic regulation of hippocampal theta rhythm, including both type I and type II oscillations, is crucial for hippocampal functions and learning.
Article
Behavioral Sciences
Jia-Yi Li, Terry B. J. Kuo, Chang-Tsen Hung, Cheryl C. H. Yang
Summary: The study demonstrates that 8-weeks of voluntary exercise increases both hippocampal theta amplitude and spatial memory in rats, suggesting a positive impact on cognitive functioning.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Viktoria S. Pendeliuk, Igor V. Melnick
Summary: Synchronization of hippocampal interneurons (INs) relies on local cell interactions and intensity of network activity. In baseline conditions, a significant portion of inhibitory postsynaptic currents coincided between cells. Network activity induced excitatory and inhibitory events, with excitatory events capable of synchronizing IN firing. Glutamatergic mechanisms play a crucial role in initiating and dominating IN synchronization.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Zeying Lu, Shengwei Xu, Hao Wang, Juntao Liu, Yuchuan Dai, Jingyu Xie, Yilin Song, Yun Wang, Yiding Wang, Lina Qu, Xinxia Cai
Summary: This study demonstrated that TSD caused deficits in spatial learning and memory maintenance in rats, which was associated with increased neuronal firing and LFP fluctuation in CA1 region. The findings also indicated that the disturbed theta activity and increased OFF period in neuronal firing after TSD disrupted the excitatory/inhibitory balance of neurons in the brain, contributing to the decline in spatial learning performance.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Clinical Neurology
Valentina Kitchigina, Liubov Shubina
Summary: The dentate gyrus (DG) is crucial for navigation and memory. The oscillatory activity of DG circuits plays an important role in cognition. Disturbances in DG rhythms during temporal lobe epilepsy (TLE) may serve as a diagnostic marker for the disease.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Abhilasha Joshi, Eric L. Denovellis, Abhijith Mankili, Yagiz Meneksedag, Thomas J. Davidson, Anna K. Gillespie, Jennifer A. Guidera, Demetris Roumis, Loren M. Frank
Summary: The hippocampus expresses spatial representations and is crucial for navigation, while the details of locomotor processes are primarily computed and represented in subcortical circuits. This study found a coordination between hippocampal spatial representations and the forelimb stepping cycle in freely behaving rats, with precise timing during spatial decisions.
Article
Neurosciences
Benjamin J. Griffiths, Maria Carmen Martin-Buro, Bernhard P. Staresina, Simon Hanslmayr
Summary: The study found that decreases in neocortical alpha/beta power during sequence perception were correlated with enhanced memory performance, while increases in hippocampal theta/gamma phase-amplitude coupling during mnemonic binding were also correlated with enhanced memory performance. This suggests a functional dissociation where neocortical alpha/beta oscillations may support the processing of incoming information relevant to memory, while hippocampal theta-gamma phase-amplitude coupling may support the binding of this information into a coherent memory trace.
Article
Engineering, Biomedical
Shuxun Dong, Jiaqing Yan, Zhenyu Xie, Yi Yuan, Hui Ji
Summary: The modulation effect of closed-loop transcranial ultrasound stimulation on theta rhythm depends on the stimulation mode and duration, showing that with peak stimulation, the relative change in amplitude and absolute power of theta rhythm decreases with the number of stimulation trials. Additionally, the relative change in amplitude and absolute power of theta rhythm increases nonlinearly with the stimulation duration under peak stimulation. This suggests that TUS has the potential to precisely modulate theta rhythm-related neural activity.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
A. Broncel, R. Bocian, P. Kios-Wojtezak, J. Konopacki
Summary: The study identified the noradrenergic receptors responsible for the production of hippocampal formation type 2 theta rhythm, showing that the selective activation of a1, a2, and 131 receptors inhibits the rhythm. This contrasts with the effects of endogenous NE, indicating the crucial role of these receptors in modulating HPC mechanisms.
Editorial Material
Biochemistry & Molecular Biology
Barbara Berger, Paul Sauseng
Summary: New research suggests that frontal midline theta EEG activity in humans controls activity in parietal cortex associated with memory maintenance, indicating strong bidirectional communication within a fronto-parietal network.
Article
Multidisciplinary Sciences
Michael S. Totty, Tugce Tuna, Karthik R. Ramanathan, Jingji Jin, Shaun E. Peters, Stephen Maren
Summary: This study reveals that coherent theta oscillations between the mPFC and HPC are correlated with fear suppression during extinction. The nucleus reuniens (RE) in the thalamus plays a crucial role in coordinating mPFC-HPC interactions, contributing to the extinction and suppression of fear memories.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Pawel Matulewicz, Arnau Ramos-Prats, Xavier Gomez-Santacana, Amadeu Llebaria, Francesco Ferraguti
Summary: This study aimed to assess the impact of mGlu(5) inactivation on neuronal oscillatory activity during fear retrieval in cued fear conditioned mice, showing that inhibition of mGlu(5) signaling decreased freezing behavior during fear retrieval and reduced theta rhythmic activity in both the mPFC and vHPC.
Article
Neurosciences
L. Stan Leung, Shahin Moallem, Marco A. M. Prado, Vania F. Prado, Liangwei Chu
Summary: This study suggests that the deficiency of acetylcholine may lead to decreased sensitivity of hippocampal local field potentials to scopolamine, while increasing sensitivity to the NMDA receptor antagonist CPP. The findings also indicate that acetylcholine deficiency could affect the theta frequency and power during walk and awake-immobility, and alterations in gamma power and theta-gamma cross-frequency coherence may be associated with loss of arousal and cognitive functions.
Article
Cell Biology
Xiaoyang Long, Sheng-Jia Zhang
Summary: Spatially selective firing of place cells, head direction cells, boundary vector/border cells, grid cells, and conjunctive cells have been identified in the primary somatosensory cortex, supporting the hypothesis that location information modulates body representation in this area of the brain. These findings offer transformative insights into how spatial information is processed and integrated in the brain, as well as the functional operations of the somatosensory cortex in the context of rehabilitation with brain-machine interfaces.
Article
Geriatrics & Gerontology
Cheryl C. H. Yang, Terry B. J. Kuo, Chun-Hsiu Chen, Wei-Yi Li, Chang-Tsen Hung, Jia-Yi Li
Summary: Aging leads to brain function decline and slower motor and behavioural responses. The hippocampal theta rhythm plays a role in cognition and locomotion. This study examines the changes in hippocampal theta oscillations during voluntary wheel running in young adult and middle-aged rats. The results show that older rats have slower theta oscillations compared to young adult rats, indicating age-related decline in brain function.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Neurosciences
Adam Broncel, Renata Bocian, Paulina Klos-Wojtczak, Jan Konopacki
BRAIN RESEARCH BULLETIN
(2019)
Review
Neurosciences
A. Broncel, R. Bocian, P. Klos-Wojtczak, K. Kulbat-Warycha, J. Konopacki
BRAIN RESEARCH BULLETIN
(2020)
Article
Neurosciences
A. Broncel, R. Bocian, P. Klos-Wojtczak, J. Konopacki
BRAIN RESEARCH BULLETIN
(2020)
Article
Neurosciences
Ahmad Salamian, Diana Legutko, Klaudia Nowicka, Bogna Badyra, Paulina Kazmierska-Grebowska, Bartosz Caban, Tomasz Kowalczyk, Leszek Kaczmarek, Anna Beroun
Summary: The application of a cholinergic agonist in the hippocampus induces the activity of matrix metalloproteinase 9 (MMP-9), affecting the frequency of excitatory and inhibitory synaptic transmission and maintaining the balance between neurons.
Review
Neurosciences
Tomasz Kowalczyk, Agata Staszelis, Paulina Kazmierska-Grebowska, Krzysztof Tokarski, Bartosz Caban
Summary: The posterior hypothalamic area is critical in various functions such as movement control, place-learning, memory processing, emotion, and arousal. The physiological occurrence of hippocampal theta rhythm is associated with the activation of specific brain structures.
Article
Biochemistry & Molecular Biology
Paulina Kazmierska-Grebowska, Marcin Siwiec, Joanna Ewa Sowa, Bartosz Caban, Tomasz Kowalczyk, Renata Bocian, M. Bruce MacIver
Summary: Theta oscillations in the brain play a crucial role in various brain functions, and disruptions in these rhythms are associated with brain disorders such as epilepsy and Alzheimer's disease. A study on the effects of lamotrigine, an HCN channel modulator, showed that it can both depress neuronal excitability and enhance theta rhythms, suggesting a complex interplay between cellular and network mechanisms. This research provides new insights into potential therapeutic targets for neurodegenerative diseases and epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Magdalena Kusek, Marcin Siwiec, Joanna Ewa Sowa, Bartosz Bobula, Wiktor Bilecki, Izabela Ciurej, Maria Kaczmarczyk, Tomasz Kowalczyk, Marzena Mackowiak, Grzegorz Hess, Krzysztof Tokarski
Summary: The research shows that activation of 5-HT7 receptors in the BA stimulates an activity-dependent enhancement of inhibitory input from local interneurons to BA principal neurons, providing insights into the possible involvement of BA serotonergic receptors in neuronal mechanisms underlying fear memory.
Review
Neurosciences
Adam Broncel, Renata Bocian, Jan Konopacki
Summary: Vagal nerve stimulation (VNS) has been used in medical treatment for over thirty years and has shown effectiveness in various homeostatic disturbances. This review focuses on the effects of VNS on brain oscillations and suggests the need for further electrophysiological experiments to understand the central mechanisms underlying VNS therapy.
Article
Neurosciences
A. Broncel, R. Bocian, P. Kios-Wojtezak, J. Konopacki
Summary: The study identified the noradrenergic receptors responsible for the production of hippocampal formation type 2 theta rhythm, showing that the selective activation of a1, a2, and 131 receptors inhibits the rhythm. This contrasts with the effects of endogenous NE, indicating the crucial role of these receptors in modulating HPC mechanisms.
Article
Neurosciences
Tomasz Kowalczyk, Agata Staszelis, Renata Bocian, Marcin Siwiec, Joanna E. Sowa, Krzysztof Tokarski, Paulina Kazmierska-Grebowska, Bartosz Caban
Summary: The posterior hypothalamic area (PHa) is an important part of the ascending brainstem hippocampal synchronizing pathway, which regulates rhythmic theta activity. In addition to its role in modulation of limbic theta activity, the PHa can also generate well-synchronized local theta field potentials by itself. Glutamatergic stimulation of PHa induces theta field oscillations in both the supramammillary and posterior hypothalamic nuclei, and these oscillations are accompanied by the activity of specific subtypes of theta-related neurons.