Article
Biochemistry & Molecular Biology
Chengya Dong, Shaohong Wen, Shunying Zhao, Si Sun, Shangfeng Zhao, Wen Dong, Pingxin Han, Qingfang Chen, Ting Gong, Wentao Chen, Wenqian Liu, Xiangrong Liu
Summary: Salidroside has been shown to improve long-term functional outcomes in ischemic stroke by inhibiting reactive astrocyte proliferation, ameliorating glial scar formation, and potentially acting through the Akt/GSK-3 beta pathway.
NEUROCHEMICAL RESEARCH
(2021)
Article
Genetics & Heredity
Yi Zhao, Ulf Lutzen, Peter Gohlke, Ping Jiang, Thomas Herdegen, Juraj Culman
Summary: Pioglitazone exerts neuroprotective effects by activating the PI3K/Akt pathway to inhibit apoptosis in ischemic brain tissue, as well as activating the antioxidant defense pathway through Nrf2, supporting the survival of injured neurons.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Plant Sciences
Caitlin W. Lehman, Kylene Kehn-Hall, Megha Aggarwal, Nicole R. Bracci, Han-Chi Pan, Lauren Panny, Robert A. Lamb, Shih-Chao Lin
Summary: Resveratrol has been shown to inhibit Venezuelan equine encephalitis virus (VEEV) replication, increase cell viability, reduce virion production, and interfere with viral attachment and entry. Additionally, its antiviral activity may be associated with the suppression of apoptotic signaling adaptors and decreased phosphorylation of the AKT/GSK-3 pathway during VEEV infection.
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jaclyn A. Connelly, Xuejing Zhang, Yuzhou Chen, Yapeng Chao, Yejie Shi, Tija C. Jacob, Q. Jane Wang
Summary: Ischemic stroke, a leading cause of death and disability in adults, requires the discovery of new targets and therapies. This study reveals an upregulation of PKD2 expression and activity in the brain and primary neurons during ischemic stroke, suggesting a potential role in neuronal survival. Deactivation of PKD2 worsened stroke outcomes in mice, indicating a neuroprotective function. AKT and CREB were identified as main signaling pathways regulated by PKD2 for neuronal survival during ischemia/reperfusion injury.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Nilay Ates, Aysun Caglayan, Zeynep Balcikanli, Elif Sertel, Mustafa Caglar Beker, Pelin Dilsiz, Ahmet Burak Caglayan, Suleyman Celik, Muhammed Furkan Dasdelen, Berrak Caglayan, Turkan Yigitbasi, Hanefi Ozbek, Thorsten Roland Doeppner, Dirk Matthias Hermann, Ertugrul Kilic
Summary: Lithium has neuroprotective effects after ischemic stroke, which involves modulation of the PI3K/Akt pathway but not the MEK/ERK pathway. High doses of lithium decrease brain perfusion and lead to animal death, while moderate doses improve brain tissue survival and reverse blood-brain barrier leakage, hemodynamic impairment, and apoptosis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shengwei Peng, Jin-hua Gu, Chun-ling Dai, Khalid Iqbal, Fei Liu, Cheng-Xin Gong
Summary: This study investigated the alterations of the AKT signaling pathway and upstream molecular pathways following cerebral ischemia/reperfusion injury. The downregulation of AKT within 12 hours of ischemia/reperfusion was found to lead to the overactivation of GSK-3 beta. Additionally, the downregulation of AKT was mediated by the downregulation of mTORC2. These findings provide new insight into cellular responses to ischemia/reperfusion brain injury and may contribute to the development of new treatments for ischemic stroke.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Shumeng Li, Yiheng Li, Pengcheng Huang, Xiaocheng Mao, Kaiyan Jiang, Ran Chen, Qing Li, Lulu Wang, Zeqing Jin, Chenyi Wan, Ying Xiong, Yaqing Yu, Wenli Sheng, Daojun Hong, Jing Lin
Summary: RNF213 is found to be associated with cerebrovascular disease and systemic vasculopathy. This study reveals that removal of Rnf213 reduces brain infarct volume and improves neurological deficit score in cerebral ischemia reperfusion injury (CIRI), possibly by regulating the Akt/GSK-313/13-catenin/Bcl-2 signaling pathway to reduce neuronal apoptosis.
Article
Neurosciences
Zhongcheng Wang, Yaxin Su, Lei Zhang, Ting Lan, Li Li, Suhua Qi
Summary: This study revealed that H3K27me3 is upregulated in the hippocampus after ischemia/reperfusion injury in rats. Treatment with GSK-126 reduced the levels of H3K27me3 and decreased neuronal apoptosis after stroke. It was also found that GSK-126 exerted its effects by negatively regulating apoptosis and the MAPK signaling pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Integrative & Complementary Medicine
Quan-long Hong, Yi-hang Ding, Jing-yi Chen, Song-sheng Shi, Ri-sheng Liang, Xian-kun Tu
Summary: Schisandrin B (Sch B) reduces apoptosis, inflammatory response, and oxidative stress in MCAO rats by modulating the PI3K/AKT pathway. Sch B has potential for treating cerebral ischemia.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Siqi Wang, Yuting Chen, Chen Xia, Chunyan Yang, Jian Chen, Li Hai, Yong Wu, Zhongzheng Yang
Summary: Glycosylated quercetin (2Glu-Que) significantly enhances the neuroprotective effects of quercetin by improving water solubility, stability, and cell viability, making it a promising candidate in neuroprotection.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Orthopedics
Ana Paula Salazar, Aline Souza Pagnussat, Gabriela Alves Pereira, Gabriela Scopel, Janice Luisa Lukrafka
BRAZILIAN JOURNAL OF PHYSICAL THERAPY
(2019)
Review
Rehabilitation
Patricia Graef Vaz, Ana Paula da Silva Salazar, Cinara Stein, Ritchele Redivo Marchese, Janice Luisa Lukrafka, Rodrigo Della Mea Plentz, Aline Souza Pagnussat
TOPICS IN STROKE REHABILITATION
(2019)
Article
Rehabilitation
Ana Paula Salazar, Veronica Cimolin, Giulia Palermo Schifino, Katia Daniele Rech, Ritchele Redivo Marchese, Aline Souza Pagnussat
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
L. E. Duran-Carabali, E. F. Sanches, F. K. Odorcyk, F. Nicola, R. G. Mestriner, L. Reichert, D. Aristimunha, A. S. Pagnussat, C. A. Netto
NEUROCHEMICAL RESEARCH
(2019)
Article
Engineering, Biomedical
Elren Passos-Monteiro, Leonardo A. Peyre-Tartaruga, Ana P. J. Zanardi, Edson S. da Silva, Pedro Jimenez-Reyes, Jean-Benoit Morin, Aline S. Pagnussat
CLINICAL BIOMECHANICS
(2020)
Article
Neurosciences
Katia Daniele Rech, Ana Paula Salazar, Ritchele Redivo Marchese, Giulia Schifino, Veronica Cimolin, Aline Souza Pagnussat
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Clinical Neurology
Aline Souza Pagnussat, Ana Paula Salazar, Camila Pinto, Ritchele Redivo Marchese, Carlos R. M. Rieder, Jose Osmar Alves Filho, Alexandre R. Franco, Ana Francisca Rozin Kleiner
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Review
Rehabilitation
Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Summary: FES has limited impact on gait speed for patients with foot drop, but shows better improvement when combined with supervised exercises. It is effective in enhancing ankle dorsiflexion, balance, and functional mobility, although with some uncertainties in the results due to high heterogeneity.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Physiology
Anelise Ineu Figueiredo, Gustavo Balbinot, Fabiane Oliveira Brauner, Aniuska Schiavo, Rafael Reimann Baptista, Aline Souza Pagnussat, Kristen Hollands, Regis Gemerasca Mestriner
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Camila Pinto, Ana Paula Salazar, Ewald Max Hennig, Graham Kerr, Aline Souza Pagnussat
Article
Chemistry, Analytical
Giulia Schifino, Veronica Cimolin, Massimiliano Pau, Maira Jaqueline da Cunha, Bruno Leban, Micaela Porta, Manuela Galli, Aline Souza Pagnussat
Summary: The study assessed the effects of foot drop stimulators (FDS) in stroke patients using spatio-temporal parameters and harmonic ratio (HR) obtained from trunk accelerations. Results indicated that FDS treatment led to increased gait speed and improved step symmetry, with further research needed to advance understanding of FDS device effects on stroke patients.
Article
Medicine, Research & Experimental
Jialin Fu, Takanori Shinjo, Qian Li, Ronald St-Louis, Kyoungmin Park, Marc G. Yu, Hisashi Yokomizo, Fabricio Simao, Qian Huang, I-Hsien Wu, George L. King
Summary: This study reveals that overexpression of PKM2 in podocytes can protect against diabetic nephropathy by preserving glomerular mitochondrial function through the activation of paracrine factors such as VEGF. The findings suggest that PKM2 may be a potential therapeutic target for the treatment of diabetic nephropathy.
Article
Developmental Biology
Janaina Zang, Anna Clara Machado Colucci, Isadora D'Avila Tassinari, Ricardo Ribeiro Nunes, Mirella Kielek Galvan Andrade, Francielle Fernandes Spies, Maikel Rosa de Oliveira, Luz Elena Duran-Carabali, Paula Rigon, Carlos Alexandre Netto, Ana Helena Paz, Luciano Sturmer de Fraga
Summary: Currently, therapeutic hypothermia (TH) is the only treatment for hypoxia-ischemia (HI) in human babies. This study evaluated the short-term effects of TH on brain injury and behavioral outcomes in neonatal rats subjected to neonatal HI. The findings suggest that TH has a sex-dependent effect, with a reduction in brain injury only observed in males. These results highlight the importance of assessing sex differences in newborns with HI and developing sex-specific treatment strategies.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Neurosciences
Rafael Teixeira Ribeiro, Andrey Vinicios Soares Carvalho, Rafael Palavro, Luz Elena Duran-Carabali, Angela Beatris Zemniacak, Alexandre Umpierrez Amaral, Carlos Alexandre Netto, Moacir Wajner
Summary: L-2-Hydroxyglutaric aciduria (L-2-HGA) is a genetic disorder characterized by deficient activity of l-2-hydroxyglutarate dehydrogenase, leading to the accumulation of l-2-hydroxyglutaric acid (L-2-HG) in the brain and biological fluids. This results in neurological symptoms and brain abnormalities, particularly in the cerebral cortex, basal ganglia, and cerebellum. A study using neonatal rats showed that intracerebroventricular injection of L-2-HG caused oxidative stress in the cerebellum, leading to neuronal loss, demyelination, astrocyte reactivity, and increased inflammatory response in the cerebral cortex and striatum. L-2-HG administration also resulted in a delay in neuromotor development and cognitive deficits in adult animals, which were prevented by the antioxidant melatonin.
NEUROTOXICITY RESEARCH
(2023)
Editorial Material
Education, Scientific Disciplines
Natali Valim Oliver Bento-Torres, Joao Bento-Torres, Andrea Camaz Deslandes, Carlos Alexandre Netto, Luiz Fernando Freire Royes, Felipe Schuch, Ionara Rodrigues Siqueira, Pamela Billig Mello-Carpes
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
