Article
Multidisciplinary Sciences
Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Yu
Summary: Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties. This study found that PS18 has neuroprotective effects in cellular and animal models of Parkinson's disease, possibly through anti-endoplasmic reticulum stress mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Xu Yi, Yujia Yang, Zhengfan Zhao, Manyu Xu, Yuan Zhang, Yingying Sheng, Junying Tian, Zhiqiang Xu
Summary: This study aimed to investigate whether serum expressions of mature brain-derived neurotrophic factor (mBDNF) and proBDNF can serve as biomarkers for early diagnosis of Parkinson's disease. The results demonstrated that mBDNF/proBDNF can be used as biomarkers for early stage Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Yuwan Lin, Miaomiao Zhou, Wei Dai, Wenyuan Guo, Jiewen Qiu, Zhiling Zhang, Mingshu Mo, Liuyan Ding, Panghai Ye, Yijuan Wu, Xiaoqin Zhu, Zhuohua Wu, Pingyi Xu, Xiang Chen
Summary: Plasma levels of OCN and OPN in PD patients are correlated with inflammation response, disease stage, and motor impairment, making them potential biomarkers for PD. The combination of plasma assessment and CSF detection enhances predictive ability for PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Ke Liu, Qing Zhou, Xueqin Zhang, Lili Ma, Baohua Xu, Rujie He
Summary: In this study, hydroxyapatite (HA) ceramic scaffolds with three different structural configurations were fabricated using digital light processing (DLP) based 3D printing technologies. The effects of the structural configurations on the morphologies and mechanical properties of the DLP-based 3D printed HA scaffolds were characterized. In vitro evaluations were conducted to assess HA scaffold behavior, and the most suitable structure of HA scaffold for bone repair was selected based on these assessments.
Article
Neurosciences
Ying Lyu, Yiying Huang, Guiying Shi, Xuepei Lei, Keya Li, Ran Zhou, Lin Bai, Chuan Qin
Summary: This study revealed gene expression changes in the five brain regions following exposure to 6-hydroxydopamine in PD rats, identifying key pathways and cascade involved in synaptic damage. The dopaminergic synapse, retrograde endocannabinoid signaling, and Gi/o-GIRK were highlighted as potential key pathways. Potential candidate genes such as Ephx2, Fam111a, and Gng2 were identified for further studies on the pathogenesis of PD.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Fide Sevgi, Eva M. Brauchle, Daniel A. Carvajal Berrio, Katja Schenke-Layland, Nicolas Casadei, Madhuri S. Salker, Olaf Riess, Yogesh Singh
Summary: Parkinson's disease is characterized by the formation of Lewy bodies in the brain, containing aggregated alpha-Synuclein. Raman imaging technology can detect alpha-Synuclein aggregates in colon tissues, showing promise as a useful tool in PD pathology research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Rossella Rotondo, Stefania Proietti, Marzia Perluigi, Elvira Padua, Fabrizio Stocchi, Massimo Fini, Vilberto Stocchi, Daniele Volpe, Maria Francesca De Pandis
Summary: The benefits of physical therapy on motor and non-motor symptoms in Parkinson's disease patients are supported by consistent evidence, with neurotrophic factors (NFs) playing a key role in neuroplasticity. However, the lack of standardized exercise training and methodological flaws in clinical trials have limited the evidence for exercise-induced changes in NFs concentration.
AGEING RESEARCH REVIEWS
(2023)
Article
Multidisciplinary Sciences
Benedict Tanudjojo, Samiha S. Shaikh, Alexis Fenyi, Luc Bousset, Devika Agarwal, Jade Marsh, Christos Zois, Sabrina Heman-Ackah, Roman Fischer, David Sims, Ronald Melki, George K. Tofaris
Summary: Alpha-synuclein plays a critical role in the pathogenesis of Parkinson's disease and related disorders, causing degeneration of human dopaminergic neurons. The toxicity of alpha-synuclein strains depends on aggregate burden, determined by monomer levels and conformation, and influenced by differential interactomes. Parkinson's disease-associated genes influence the phenotypic manifestation of strains in human neurons.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Mahmoud A. Alomari, Hanan Khalil, Omar F. Khabour, Karem H. Alzoubi
Summary: The study revealed a relationship between BDNF and lipid profile, suggesting the importance of BDNF for lipid metabolism in patients with Parkinson's disease.
Review
Pharmacology & Pharmacy
Yiqiu Liu, Junyu Deng, Ye Liu, Wei Li, Xuqiang Nie
Summary: Parkinson's disease is a neurodegenerative disorder characterized by motor dysfunction, autonomic dysfunction, and other non-motor symptoms. Pathologically, it involves degeneration of dopaminergic neurons, formation of Lewy bodies, and neuroinflammation. Treatment options mainly focus on increasing dopamine levels or stimulating dopamine receptors, with research showing potential benefits from fibroblast growth factor and its receptor in protecting dopaminergic neurons and reducing neuroinflammation in PD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Carolina Pinheiro Campos, Raquel Chacon Ruiz Martinez, Aline Vivian Vatti Auada, Ivo Lebrun, Erich Talamoni Fonoff, Clement Hamani, Rosana Lima Pagano
Summary: This study investigated the effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on striatal glial cells, inflammation, and glutamate/GABA concentration in a rat model of Parkinson's disease (PD). The results suggest that DBS has beneficial effects mediated by the inhibition of glial cell activation, neuroinflammation, and glutamate excitotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Maria Izco, Ariane Vettorazzi, Raquel Forcen, Javier Blesa, Maria de Toro, Natalia Alvarez-Herrera, J. Mark Cooper, Elena Gonzalez-Penas, Adela Lopez de Cerain, Lydia Alvarez-Erviti
Summary: Research indicates that oral exposure to low levels of the mycotoxin ochratoxin A (OTA) can lead to pathological changes associated with Parkinson's disease (PD) in mice, such as loss of dopaminergic innervation and cell dysfunction. These findings suggest a potential role of OTA in the pathogenesis of PD.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emily R. Mahoney, Logan Dumitrescu, Annah M. Moore, Francis E. Cambronero, Philip L. De Jager, Mary Ellen Koran, Vladislav A. Petyuk, Rena A. S. Robinson, Sandeep Goyal, Julie A. Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: The study revealed that the VEGF gene family plays a complex role in neuroprotection and is associated with cognitive performance, cognitive decline, and Alzheimer's disease pathology.
MOLECULAR PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Heba M. Mansour, Ahmed F. Mohamed, Mahmoud M. Khattab, Aiman S. El-Khatib
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits induced by dopaminergic neuronal death. Despite improved knowledge of PD's etiology and various medications, finding a successful neuroprotective therapy remains challenging. Recent studies have shown that the FDA-approved anti-cancer medication, Lapatinib (LAP), exerts neuroprotective effects in other neurodegenerative diseases. In this study, administration of LAP in rotenone-treated rats improved motor impairment, histopathological alterations, and dopaminergic neurons. LAP also restored the antioxidant defense system and modulated key pathological markers of PD. These findings suggest that LAP has neuroprotective effects in PD and could be a potential disease-modifying drug.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Axel Leppert, Helen Poska, Michael Landreh, Axel Abelein, Gefei Chen, Jan Johansson
Summary: The BRICHOS protein superfamily is associated with various human diseases and can modulate the aggregation pathways of amyloid-forming substrates. The ability to interfere with different aggregation pathways depends on the quaternary structure and surface motifs of BRICHOS domains. This review provides an overview of the BRICHOS protein family and discusses the diverse molecular chaperone-like functions of BRICHOS domains, as well as the potential use of the BRICHOS domain as a treatment for protein aggregation disorders with blood-brain barrier permeability.
Article
Neurosciences
Lauren Broom, Peter Jenner, Sarah Rose
EXPERIMENTAL NEUROLOGY
(2015)
Article
Clinical Neurology
Louise Lincoln, Ria Fisher, Michael J. Jackson, Peter Jenner, John Neumeyer, Anna W. Sromek, Andrew J. Lees, Sarah Rose
MOVEMENT DISORDERS
(2016)
Article
Multidisciplinary Sciences
Michel Modo, William R. Crum, Madeline Gerwig, Anthony C. Vernon, Priya Patel, Michael J. Jackson, Sarah Rose, Peter Jenner, Mahmoud M. Iravani
Article
Multidisciplinary Sciences
Sara Pritchard, Michael J. Jackson, Atsuko Hikima, Lisa Lione, Christopher D. Benham, K. Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M. Iravani
Article
Chemistry, Medicinal
Ria Fisher, Louise Lincoln, Michael J. Jackson, Vincenzo Abbate, Peter Jenner, Robert Hider, Andrew Lees, Sarah Rose
PHYTOTHERAPY RESEARCH
(2018)
Article
Endocrinology & Metabolism
X. F. Li, M. H. Hu, S. Y. Li, C. Geach, A. Hikima, S. Rose, M. P. Greenwood, M. Greenwood, D. Murphy, L. Poston, S. L. Lightman, K. T. O'Byrne
Article
Pharmacology & Pharmacy
Maria Papathanou, Peter Jenner, Mahmoud Iravani, Michael Jackson, Kim Stockwell, Isabel Strang, Bai-Yun Zeng, Andrew C. McCreary, Sarah Rose
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Michael J. Hurley, Michael J. Jackson, LanceA. Smith, Sarah Rose, Peter Jenner
JOURNAL OF MOLECULAR NEUROSCIENCE
(2014)
Article
Clinical Neurology
Mahmoud M. Iravani, Mona Sadeghian, Sarah Rose, Peter Jenner
JOURNAL OF NEURAL TRANSMISSION
(2014)
Article
Clinical Neurology
Monika J. Brzozowski, Peter Jenner, Sarah Rose
JOURNAL OF NEURAL TRANSMISSION
(2015)
Article
Multidisciplinary Sciences
Anne Michel, Jean-Marie Nicolas, Sarah Rose, Michael Jackson, Peter Colman, Willy Brione, David Sciberras, Pierandrea Muglia, Dieter K. Scheller, Martin Citron, Patrick Downey
Article
Clinical Neurology
Andres Asser, Atsuko Hikima, Mari Raki, Kim Bergstrom, Sarah Rose, Julius Juurmaa, Villem Krispin, Mari Muldmaa, Stella Lilles, Hanna Raetsep, Peter Jenner, Sulev Koks, Pekka T. Maennisto, Pille Taba
JOURNAL OF NEURAL TRANSMISSION
(2020)
Article
Neurosciences
Ria Fisher, Atsuko Hikima, Rebecca Morris, Michael J. Jackson, Sarah Rose, Mark A. Varney, Ronan Depoortere, Adrian Newman-Tancredi
Editorial Material
Neurosciences
Luigi Zecca, Christian Pifl, Stanley Fahn, David Sulzer, Ruggero G. Fariello
Summary: By studying Parkinson's disease and the treatment with L-DOPA, Hornykiewicz improved the lives of many individuals and made significant contributions to neurology and medical science.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Erika Coletto, John S. Dolan, Sara Pritchard, Alex Gant, Atsuko Hikima, Michael J. Jackson, Christopher D. Benham, K. Ray Chaudhuri, Sarah Rose, Peter Jenner, Mahmoud M. Iravani
NPJ PARKINSONS DISEASE
(2019)