期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 36, 期 6, 页码 2782-2788出版社
WILEY
DOI: 10.1111/j.1460-9568.2012.08172.x
关键词
autism spectrum disorders; plasticity; theta burst stimulation; transcranial magnetic stimulation
资金
- National Center for Research Resources: Harvard-Thorndike Clinical Research Center at BIDMC [NCRR MO1 RR01032]
- National Center for Research Resources: Harvard Clinical and Translational Science Center [UL1 RR025758]
- NIH [K24 RR018875, F32MH080493]
- Autism Speaks
- Nancy Lurie Marks Family Foundation
Most candidate genes and genetic abnormalities linked to autism spectrum disorders (ASD) are thought to play a role in developmental and experience-dependent plasticity. As a possible index of plasticity, we assessed the modulation of motor corticospinal excitability in individuals with Aspergers syndrome (AS) using transcranial magnetic stimulation (TMS). We measured the modulatory effects of theta-burst stimulation (TBS) on motor evoked potentials (MEPs) induced by single-pulse TMS in individuals with AS as compared with age-, gender- and IQ-matched neurotypical controls. The effect of TBS lasted significantly longer in the AS group. The duration of the TBS-induced modulation alone enabled the reliable classification of a second study cohort of subjects as AS or neurotypical. The alteration in the modulation of corticospinal excitability in AS is thought to reflect aberrant mechanisms of plasticity, and might provide a valuable future diagnostic biomarker for the disease and ultimately offer a target for novel therapeutic interventions.
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