Article
Biology
Carlos Andres Mendez, Alessia Celeghin, Matteo Diano, Davide Orsenigo, Brian Ocak, Marco Tamietto
Summary: The superior colliculus (SC) is capable of recognizing and categorizing emotional features from retinal information, independently of additional processing in the visual cortex or limbic areas. The SC model exhibits similar error patterns to humans and shows preference for specific visual features and processing pathways.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Norihiro Takakuwa, Kaoru Isa, Hirotaka Onoe, Jun Takahashi, Tadashi Isa
Summary: Blindsight is a phenomenon where some patients can respond to visual stimuli in their lesion-affected visual field even after damage to the primary visual cortex (V1). The study used pharmacological inactivation of the pulvinar and LGN to clarify their roles in a simple visually guided saccades task, finding that both regions play key roles in performing the task after V1 lesioning.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuma Osako, Tomoya Ohnuki, Yuta Tanisumi, Kazuki Shiotani, Hiroyuki Manabe, Yoshio Sakurai, Junya Hirokawa
Summary: The study reveals the significant role of non-sensory neurons in V1 and PPC in reflecting animals' internal states and driving behavioral responses to visual stimuli.
Article
Neurosciences
Clara Bourrelly, Corentin Massot, Neeraj J. Gandhi
Summary: Sensorimotor transformation is the process of sensing and responding to stimuli, and this study investigates the neural activity in the superior colliculus during visually guided eye movements. The study compares spike bursts and local field potential (LFP) modulations along the dorsoventral axis of the superior colliculus and finds a transition from sensory to motor response in both signals, with the LFP transition occurring deeper than the spike burst transition. The results suggest a fast and efficient transformation between LFP modulation and spike burst during sensation, but not during action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Satomi Inomata-Terada, Hideki Fukuda, Shin-ichi Tokushige, Shun-ichi Matsuda, Masashi Hamada, Yoshikazu Ugawa, Shoji Tsuji, Yasuo Terao
Summary: This study investigated the pathophysiology of hereditary spinocerebellar degeneration (SCA) with pure cerebellar manifestation using saccade recordings. The results showed increased saccade latency and amplitude, as well as greater variability, in SCA patients compared to normal subjects. These changes correlated with the severity of cerebellar symptoms. The study also found that the saccade velocity profile and the relationship between saccade amplitude and peak velocity were affected by disease progression. This research demonstrates the importance of saccade recording in understanding the cerebellar pathophysiology of SCA.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Christoph Helmchen, Bjoern Machner, Hannes Schwenke, Andreas Sprenger
Summary: This study investigated the effect of bilateral deep cerebellar nuclei lesions on the initial acceleration of human smooth pursuit and other types of eye movements. The results showed that the initial pursuit acceleration was not significantly reduced in patients with bilateral lesions. The findings suggest independent influences on the neural processes controlling saccadic and pursuit eye movements in the deep cerebellar nuclei.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Qingpeng Yu, Hang Fu, Gang Wang, Jiayi Zhang, Biao Yan
Summary: The study found that visual experience can potentiate spontaneous activity in mouse superior colliculus neurons, with feature selectivity for direction and orientation. By stimulating retinal ganglion cells or optogenetically activating parvalbumin neurons, this potentiation can be attenuated or blocked.
NEUROSCIENCE BULLETIN
(2021)
Article
Biology
Ya-tang Li, Markus Meister
Summary: The superior colliculus in the brain is a crucial visual processing station that receives input from various types of retinal ganglion cells. Through recording mouse superficial SC neurons, we identified 24 functional types using an unsupervised clustering algorithm. These types can be grouped into two categories: one that responds similarly to retinal ganglion cells and another with more diverse and specialized stimulus selectivity. Cells of the same functional type tend to cluster together in anatomical space, and the visual representation in the SC has lower dimensionality compared to the retina, suggesting a sifting process along the visual pathway.
Article
Neurosciences
Chih-Yang Chen, Denis Matrov, Richard Veale, Hirotaka Onoe, Masatoshi Yoshida, Kenichiro Miura, Tadashi Isa
Summary: By comparing the saccadic behaviors of marmosets, macaques, and humans, researchers found that these species exhibit similar kinematics and saliency-driven saccadic behavior, though with varying parameters. The results suggest that the marmoset shares neural mechanisms with macaques and humans for saccadic control, making it a suitable model for studying neural mechanisms related to active vision and attention.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Robert M. McPeek
Summary: Neurons governing saccadic eye movements multiplex signals related to sensation, cognition, and movement. A new study reveals that the initiation of saccade is controlled by the temporal stability of rising population activity.
Article
Neurosciences
Yih-Giun Cherng, Frederic Crevecoeur, Chin-An Wang
Summary: The study found that pupillary luminance responses influence the generation of saccades, with changes in luminance affecting pupil response, pupil size variations, and saccadic behavior. Additionally, luminance conditions also modulate saccade kinematics, leading to performance differences.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Miranda J. Munoz, Rishabh Arora, Yessenia M. Rivera, Quentin H. Drane, Gian D. Pal, Leo Verhagen Metman, Sepehr B. Sani, Joshua M. Rosenow, Lisa C. Goelz, Daniel M. Corcos, Fabian J. David
Summary: This study found that medication worsens saccade performance and benefits reaching performance, while STN-DBS benefits both saccade and reaching performance. These findings suggest potential physiological changes due to treatment.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Jing Jia, Zhen Puyang, Qingjun Wang, Xin Jin, Aihua Chen
Summary: The frontal eye field (FEF) exhibits different response patterns during sequential saccades, which are context-dependent and dynamically changing. Pharmacological inactivation of FEF has a negative impact on the performance of learned sequential saccades in monkeys.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Santoshi Ramachandran, Vallabh E. Das
Summary: This study investigated the fixation-preference behavior in strabismic individuals and verified the influencing factors through recording the activity of neurons in strabismic monkeys. The results demonstrated the significant role of visual suppression in oculomotor fixation-preference and supported the utilization of a competition framework.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Benjamin Tari, Luc Tremblay, Matthew Heath
Summary: Through two experiments, the study examined the nature of the remote distractor effect, revealing that it is sensory specific and arises from conflicting visual signals. Additionally, results indicate that acoustic distractors support intersensory facilitation, optimizing oculomotor planning.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Takuro Ikeda, Susan E. Boehnke, Robert A. Marino, Brian J. White, Chin-An Wang, Ron Levy, Douglas P. Munoz
EUROPEAN JOURNAL OF NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Masatoshi Yoshida, Tadashi Isa
SCIENTIFIC REPORTS
(2015)
Review
Biology
Richard Veale, Ziad M. Hafed, Masatoshi Yoshida
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2017)
Article
Neurosciences
Xiaoguang Tian, Masatoshi Yoshida, Ziad M. Hafed
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Masatoshi Yoshida, Richard Veale
NEUROSCIENCE RESEARCH
(2014)
Article
Neurosciences
Chih-Yang Chen, Denis Matrov, Richard Veale, Hirotaka Onoe, Masatoshi Yoshida, Kenichiro Miura, Tadashi Isa
Summary: By comparing the saccadic behaviors of marmosets, macaques, and humans, researchers found that these species exhibit similar kinematics and saliency-driven saccadic behavior, though with varying parameters. The results suggest that the marmoset shares neural mechanisms with macaques and humans for saccadic control, making it a suitable model for studying neural mechanisms related to active vision and attention.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biology
Rikako Kato, Takuya Hayashi, Kayo Onoe, Masatoshi Yoshida, Hideo Tsukada, Hirotaka Onoe, Tadashi Isa, Takuro Ikeda
Summary: Research using PET imaging reveals altered brain activity in blindsight macaques that lack visual awareness but can still perform visual motor tasks, showing significant changes in activity of the lateral bank of the intraparietal sulcus (lbIPS) bilaterally. Injection of muscimol into this region impairs visuomotor performance, suggesting a role for bilateral lbIPS in visuomotor function in blindsight conditions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Chihiro Yokoyama, Joonas A. Autio, Takuro Ikeda, Jerome Sallet, Rogier B. Mars, David C. Van Essen, Matthew F. Glasser, Norihiro Sadato, Takuya Hayashi
Summary: Through the lens of systems neuroscience, this study examines the neural mechanisms underlying social behaviors, revealing a correlation between cortical neuron number and social capabilities across primates. By utilizing comparative connectomics and functional MRI, similarities in functional organization of mirror neuron system and default-mode network in macaque monkeys and humans are highlighted, shedding light on the neurobiology of social cognition and complexity. The integration of Human Connectome Project-style comparative neuroimaging, hyperscanning, behavioral and multi-modal investigations is expected to provide valuable insights into the evolutionary foundations of human social behavior.
Article
Neurosciences
Zlata Polyakova, Masao Iwase, Ryota Hashimoto, Masatoshi Yoshida
Summary: A pharmacological model of schizophrenia symptoms using a subanesthetic dose of ketamine in marmosets was used to study the effects on eye movement characteristics during free-viewing. Ketamine was found to affect saccadic eye movements in marmosets, reducing the amplitude and scanpath length of saccades while increasing the duration of saccades and fixations. These findings suggest that ketamine affects visual exploration but not the oculomotor aspect of saccades in marmosets.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Takuro Ikeda, Joonas A. Autio, Akihiro Kawasaki, Chiho Takeda, Takayuki Ose, Masahiko Takada, David C. Van Essen, Matthew F. Glasser, Takuya Hayashi
Summary: Night monkeys are the only genus of monkeys that occupy a nocturnal niche and their cerebral cortex shows selective expansion in sensory areas related to visual motion and auditory processing, which may reflect adaptations to a nocturnal environment.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Neurosciences
Masatoshi Yoshida, Ziad M. Hafed, Tadashi Isa
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2017)
Proceedings Paper
Computer Science, Artificial Intelligence
Yusaku Takeda, Koji Iwase, Toshihiro Hara, Atsuhide Kishi, Kazuo Nishikawa, Richard Veale, Masatoshi Yoshida, Tadashi Isa, Takahide Nouzawa
ADVANCES IN NEUROERGONOMICS AND COGNITIVE ENGINEERING
(2017)
Article
Neurosciences
Xiaoguang Tian, Masatoshi Yoshida, Ziad M. Hafed
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2016)
Proceedings Paper
Computer Science, Artificial Intelligence
Richard Veale, Tadashi Isa, Masatoshi Yoshida
2015 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION (CEC)
(2015)
Proceedings Paper
Computer Science, Cybernetics
Richard Veale, Tadashi Isa, Masatoshi Yoshida
2015 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC 2015): BIG DATA ANALYTICS FOR HUMAN-CENTRIC SYSTEMS
(2015)