Article
Environmental Studies
Ingvild H. Blomstervik, Svein Ottar Olsen
Summary: This study presents an extended analysis of the progress of novelty in tourism, categorizing it into three thematic clusters based on core, antecedents, and consequences. The findings suggest that novelty in tourism is mostly influenced by emotional appraisal attributes and novelty-seeking personality traits, and can drive consequences such as tourist satisfaction, loyalty, and value.
TOURISM MANAGEMENT
(2022)
Article
Psychology, Multidisciplinary
Emily L. Smith, Elizabeth M. Anglis, Shevaun D. Neupert
Summary: This study explores the association between individual differences in delinquency and emotional reactivity. The findings suggest that higher levels of delinquency and decreases in mindfulness are associated with higher negative affect. The study also reveals that fluctuations in mindfulness depend on individual differences in delinquency, indicating the importance of considering both factors in understanding emerging adults' daily emotional well-being.
CURRENT PSYCHOLOGY
(2023)
Article
Psychiatry
Pamela M. Maras, Peter Blandino, Elaine K. Hebda-Bauer, Stanley J. Watson, Huda Akil
Summary: The study found differences in the morphological features of microglia between selectively bred rat lines bLRs and bHRs, despite similar numbers of microglia in the two lines. Specifically, microglia from bLRs exhibited more complex morphology, suggesting a possible activation stage.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Michael Schaefer, Anja Kuehnel, Felix Schweitzer, Soeren Enge, Matti Gaertner
Summary: Research has shown that placebos can have beneficial effects even without deception. Several studies have reported improvements in pain, depression, or anxiety. However, it remains unclear whether these effects are biologically objective or simply a bias in response, and the neural mechanisms associated with open-label placebos are still not well-understood.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Leonie Geissmann, David Coynel, Andreas Papassotiropoulos, Dominique J. F. de Quervain
Summary: This study investigates the neural correlates of individual differences in episodic memory performance using fMRI data. The authors find that activity in the hippocampus, orbitofrontal cortex, and posterior cingulate cortex explains individual variability in memory performance. Additionally, they identify nine functional connectivity networks that are related to individual memory differences.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Christopher A. Kelly, Tali Sharot
Summary: Information-seeking behavior is associated with three diverse motives: usefulness in directing action, emotional impact, and relevance to frequently considered concepts. Different individuals assign varying weights to these factors when seeking information, with these weights showing stability over time and correlations with mental health.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Elizabeth A. Shupe, Matthew E. Glover, Keaton A. Unroe, Ilan A. Kerman, Sarah M. Clinton
Summary: In rodents with inborn differences in emotionality, research suggests that poly-synaptic projections from the PVN to skeletal muscle may regulate emotional motor responses to stress. This neuroanatomical difference mirrors behavioral observations, indicating that perturbations in PVN motor circuitry could play a role in psychomotor disturbances seen in depression or anxiety-related disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Allison K. Diachina, Shevaun D. Neupert
Summary: This study focuses on positive emotional reactivity in response to stressors, finding that older adults rely more on outcome fantasy when coping with home-related stressors, while younger adults experience a stronger increase in positive affect when forecasting home stressors.
AGING & MENTAL HEALTH
(2022)
Article
Clinical Neurology
David A. Cole, Megan E. Gabruk, Bridget A. Nestor, Qimin Liu, Abbegail J. Lovette, Yinghao Zhang, Cassandra R. Mick
Summary: This study found that depressive symptoms were positively related to within-person emotional and cognitive reactivity, but not to between-person operationalizations. Recommendations were made to distinguish between-person from within-person dimensions in future research.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Social
Ceren Gokdag
Summary: Individual differences in emotional processes play a crucial role in psychological problems. This study aimed to test a model that negative emotional reactivity explains psychological distress via emotion dysregulation. The results indicated that negative emotional reactivity is associated with psychological symptoms mediated by emotion dysregulation.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2023)
Article
Food Science & Technology
C. Cinar, L. W. Wesseldijk, A. K. Karinen, P. Jern, J. M. Tybur
Summary: This study examined the genetic and environmental factors influencing people's preferences for meats and plants, as well as their meat and plant neophobia, and vegetarianism/veganism. The research found correlations between childhood exposure to meats and plants and adult preferences, and sex differences in the heritability of these factors. Interestingly, different genes were found to influence men's and women's meat preferences, while abstention from meat (vegetarianism/veganism) was highly heritable at 76%.
FOOD QUALITY AND PREFERENCE
(2022)
Review
Psychology, Developmental
Charlotte F. Huggins, Gemma Donnan, Isobel M. Cameron, Justin H. G. Williams
Summary: The study suggests that emotional self-awareness is poorer in individuals with autism, especially during adolescence and later stages, possibly due to negative self-beliefs in self-perception.
Article
Psychiatry
Christine Ecker, Charlotte M. Pretzsch, Anke Bletsch, Caroline Mann, Tim Schaefer, Sara Ambrosino, Julian Tillmann, Afsheen Yousaf, Andreas Chiocchetti, Michael Lombardo, Varun Warrier, Nico Bast, Carolin Moessnang, Sarah Baumeister, Flavio Dell'Acqua, Dorothea L. Floris, Mariam Zabihi, Andre Marquand, Freddy Cliquet, Claire Leblond, Clara Moreau, Nick Puts, Tobias Banaschewski, Emily J. H. Jones, Luke Mason, Sven Bolte, Andreas Meyer-Lindenberg, Antonio M. Persico, Sarah Durston, Simon Baron-Cohen, Will Spooren, Eva Loth, Christine M. Freitag, Tony Charman, Guillaume Dumas, Thomas Bourgeron, Christian F. Beckmann, Jan K. Buitelaar, Declan G. M. Murphy
Summary: This study investigates the neuroanatomical differences in individuals with autism spectrum disorder (ASD) and their genomic underpinnings. The findings suggest a link between macroscopic differences in brain anatomy and molecular mechanisms underlying heterogeneity in ASD. The study also identifies potential targets for stratification and subtyping of ASD.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Review
Ecology
Ab. Matteen Rafiqi, Priscila G. Polo, Nihan Sultan Milat, Zelal Ozgur Durmus, Birguel colak-Al, Mauricio E. Alarcon, Fatma Zehra cagil, Arjuna Rajakumar
Summary: Endosymbiosis refers to the interconnection of two independently existing entities, behaving as a single unit. Multicellular hosts need to integrate endosymbionts into their developmental genetic network to maintain their relationship. Developmental integration involves innovations in cell type, gene function, gene regulation, and metabolism, which depend on existing ecological interactions and may lead to mutual interdependence. Although recent studies have made progress in understanding the mechanisms of interdependence, the study of developmental integration is still in its early stages. This review focuses on mutualistic endosymbiosis in insects as a model to gain a comprehensive understanding of endosymbiosis and pave the way for future research on the endosymbiotic theory of evolution.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Geriatrics & Gerontology
Maria Wirth, Andreas Voss, Klaus Rothermund
Summary: Emotional aging research focuses on age-related improvements in motivation. Socioemotional selectivity theory proposes that as individuals age, they favor emotion-related goals and savor positive but avoid negative emotions. Our computational approach provides partial support for these predictions.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Psychology, Biological
Samir Rana, Phyllis C. Pugh, J. Michael Wyss, Sarah M. Clinton, Ilan A. Kerman
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Neurosciences
Isabelle A. Birt, Megan H. Hagenauer, Sarah M. Clinton, Cigdem Aydin, Peter Blandino, John D. H. Stead, Kathryn L. Hilde, Fan Meng, Robert C. Thompson, Huzefa Khalil, Alex Stefanov, Pamela Maras, Zhifeng Zhou, Elaine K. Hebda-Bauer, David Goldman, Stanley J. Watson, Huda Akil
Summary: By studying gene expression in the hippocampus of rats with high and low exploratory activity, candidate genes associated with metabolism, mood, and neurodevelopment were identified, suggesting divergent developmental trajectories and different reactions to the environment in bHR and bLR rats.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Elizabeth A. Shupe, Matthew E. Glover, Keaton A. Unroe, Ilan A. Kerman, Sarah M. Clinton
Summary: In rodents with inborn differences in emotionality, research suggests that poly-synaptic projections from the PVN to skeletal muscle may regulate emotional motor responses to stress. This neuroanatomical difference mirrors behavioral observations, indicating that perturbations in PVN motor circuitry could play a role in psychomotor disturbances seen in depression or anxiety-related disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Sarah M. Clinton, Elizabeth A. Shupe, Matthew E. Glover, Keaton A. Unroe, Chelsea R. McCoy, Joshua L. Cohen, Ilan A. Kerman
Summary: Animal models, such as selectively bred Sprague-Dawley rats, provide important tools to study factors contributing to individual differences in emotionality and stress reactivity. Through selective breeding for differences in novelty exploration, rats with low versus high locomotor response show significant differences in behavioral domains relevant to anxiety and depression. These differences in behavior, including high levels of fear, avoidance, and passive stress coping in Low Novelty Responder (LR) rats compared to High Responder (HR) rats, are heritable traits that emerge early in life and are driven by alterations in the developing amygdala and hippocampus. Epigenomic and transcriptomic profiling in these rats suggest that DNA methylation, microRNAs, and differences in monoaminergic transmission contribute to their distinct behavioral phenotypes. This work demonstrates how animal models can effectively be used to study neural and molecular factors influencing emotional behavior and contribute to a better understanding of neurobiological mechanisms involved in emotional disorders.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jun Chen, Katriel E. Cho, Daria Skwarzynska, Shaylyn Clancy, Nicholas J. Conley, Sarah M. Clinton, Xiaokun Li, Li Lin, J. Julius Zhu
Summary: Recent studies have shown that genetically encoded neuromodulatory transmitter sensors, in combination with superresolution and deconvolution microscopy, can visualize neuromodulatory transmission at nanoscale or microscale for the first time. Validation of high-performing sensors has delineated fundamental synaptic properties of neuromodulatory transmission and revealed unexpected fine control and precision in neuromodulation.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Sarah M. Clinton, Keaton A. Unroe, Elizabeth A. Shupe, Chelsea R. McCoy, Matthew E. Glover
Summary: Individual differences in temperament can influence how individuals respond to stress and may determine vulnerability to emotional disorders. Research using a rat model of temperamental differences has shown that rats bred for high versus low behavioral response to novelty exhibit significant behavior differences relevant to emotional disorders.
Article
Neurosciences
M. E. Glover, J. L. Cohen, J. R. Singer, M. N. Sabbagh, J. R. Rainville, M. T. Hyland, C. D. Morrow, C. T. Weaver, G. E. Hodes, Ilan A. Kerman, S. M. Clinton
Summary: This study examined the relationships between microbiota, immune markers, and behavior in rats bred for different emotional behavior phenotypes. The findings suggest that antibiotic treatment disrupts the microbiome in rats and affects their behavior.
Article
Developmental Biology
Elizabeth A. Shupe, Sarah M. Clinton
Summary: This study using Sprague Dawley rats investigated the impact of limited resource availability on maternal behavior and physiological and emotional behavior outcomes in offspring. The findings indicate that early life adversity can alter maternal care, affect pup's body temperature and weight gain, but does not impact adult offspring's social or emotional behavior outcomes.
DEVELOPMENTAL PSYCHOBIOLOGY
(2021)
Article
Neurosciences
Keaton A. Unroe, Matthew E. Glover, Elizabeth A. Shupe, Ningping Feng, Sarah M. Clinton
Summary: SSRI exposure during perinatal period affects neurodevelopment and increases risk for psychiatric illness in offspring. Changes in BAI3 signaling may contribute to adverse effects of perinatal SSRI exposure, as evidenced by altered expression in patients with depression and schizophrenia.
Article
Cell Biology
Gareth M. Rurak, Stephanie Simard, Moises Freitas-Andrade, Baptiste Lacoste, Francois Charih, Amanda Van Geel, John Stead, Barbara Woodside, James R. Green, Gianfilippo Coppola, Natalina Salmaso
Summary: This study examines the sex differences and developmental changes in cortical astroglial cells. The results reveal two distinct phenotypes of astroglia during early and late development, while sex differences are mainly reflected in gene expression patterns during development.
Editorial Material
Neurosciences
Sarah M. Clinton
BIOLOGICAL PSYCHIATRY
(2022)
Article
Developmental Biology
Keaton A. Unroe, Jessica L. Maltman, Elizabeth A. Shupe, Sarah M. Clinton
Summary: Manipulating serotonin levels in the developing brain can have a range of effects on brain function and behavior. This study found that early-life exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants disrupted maternal behavior in adult female rats, including decreased maternal care and increased behavioral inconsistency. The study also showed that early-life SSRI exposure altered the expression of specific 5-HT receptor transcripts in regions involved in maternal care. These findings suggest that early alterations to 5-HT signaling through SSRI exposure may disrupt nurturing parental behaviors and 5-HT receptor expression in affected female rat offspring.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Article
Neurosciences
Matthew E. Glover, Keaton A. Unroe, Mohamad M. Moughnyeh, Chelsea McCoy, Ilan A. Kerman, Sarah M. Clinton
Summary: Serotonin plays a crucial role in regulating various functions and neurodevelopmental processes, and its genetic and environmental factors can have an impact on brain structure and behavior, potentially contributing to neuropsychiatric disorders.
NEUROSCIENCE LETTERS
(2022)
Meeting Abstract
Neurosciences
Sarah Clinton, Ilan Kerman, Matthew Glover
NEUROPSYCHOPHARMACOLOGY
(2019)