Article
Multidisciplinary Sciences
Mi Gyeom Kim, Che Lin Kim, Young Sik Kim, Ju Woong Jang, Gyun Min Lee
Summary: Cell surface HSPG-mediated endocytosis leads to low yields of recombinant human bone morphogenetic proteins (rhBMPs) in CHO cell cultures, but blocking internalization significantly increases the production of rhBMP-2.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Alexandre P. Thiery, Ailin Leticia Buzzi, Eva Hamrud, Chris Cheshire, Nicholas M. Luscombe, James Briscoe, Andrea Streit
Summary: The vertebrate neural plate border is a transient territory that contains precursors for all ectodermal derivatives. Through single cell RNA sequencing, this study explores the diversity and heterogeneity of cells in the neural plate border and reveals the dynamic expression patterns and fate enrichment of genes previously classified as neural plate border specifiers. Furthermore, the study suggests that individual cells in the neural plate border co-express competing transcriptional programs, indicating their undecided fate.
Article
Dermatology
Zhengsen Wang, Yixuan Chen, Meiyang Chen, Yanding Zhang
Summary: This study demonstrates that overexpression of Fgf8 in epidermal cells leads to stunted growth, severe hypotrichosis, and arrested hair follicle development in mice. The inhibition of epidermal cell proliferation and promotion of apoptosis by excessive Fgf8 expression plays a crucial role in these phenotypes, along with the downregulation of Shh and upregulation of Bmp4.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Cell Biology
Stefan Washausen, Wolfgang Knabe
Summary: Epibranchial placodes in the vertebrate embryo are regulated by unique combinations of FGF and/or BMP signaling pathways, with neurogenesis depending on FGF signals of varying degrees in each placode.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Anthony Estienne, Lauriane Relav, Morad Benkoura, Danielle Monniaux, Fanny Morin, Stephane Fabre, Christopher A. Price
Summary: Increasing the efficiency of farm animal reproduction is important for reducing the environmental impact of food production systems. This study investigates the factors that decrease oocyte health and how fibroblast growth factor 18 (FGF18) is regulated in the ovarian follicle. The researchers found that FGF18 secretion is controlled by intrafollicular factors and is linked to fertility. They also discovered that BMP4 stimulates FGF18 secretion from thecal endothelial cells, which affects fertility. Understanding these processes can help improve reproductive efficiency in farm animals.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biology
Humberto G. Ferron, Philip C. J. Donoghue
Summary: The study analyzes the evolution of swimming speed in early vertebrates based on fin morphology and challenges the hypothesis of a trend towards more active lifestyles in the lineage leading to jawed groups.
COMMUNICATIONS BIOLOGY
(2022)
Review
Developmental Biology
Anh Phuong Le, Jin Kim, Karl R. Koehler
Summary: Developing organs are influenced by physical interaction with the embryo's environment. Recent advancements in live-cell imaging and material science have enhanced our understanding of the mechanical forces driving organ formation. This article provides a comprehensive overview of the forces involved in embryonic development and focuses on specific organs related to our senses, such as the eyes, inner ears, nose, and skin. The review highlights animal studies that demonstrate the crucial role of mechanical forces in processes like sensory placode thickening, cochlea coiling, and hair lengthening. Additionally, the article discusses how microfabricated organoid systems offer unparalleled insights into the physical principles of human development.
Article
Biochemistry & Molecular Biology
Yining Zhang, Yixin Zhao, Zhengsong Xie, Molin Li, Yujiao Liu, Xiaolin Tu
Summary: Our study confirmed that BMP-7 mediates the anabolic actions of Wnt/β-catenin signaling in osteocytes. This provides new evidence for the clinical application of BMP-7-overexpressed osteocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Karo Parsegian
Summary: This study explores the interaction between BMP and FGF signaling during odontoblast and osteoblast differentiation. The results show that BMP2 and FGF2 have reciprocal stimulatory effects on odontoblast differentiation, while their effects on osteoblast differentiation are independent of each other.
CONNECTIVE TISSUE RESEARCH
(2023)
Review
Endocrinology & Metabolism
Federica Marelli, Giuditta Rurale, Luca Persani
Summary: This review provides an update on recent advancements in understanding the early steps of thyroid differentiation in zebrafish, highlighting the physiological processes and molecular mechanisms involved. The study reveals a complex crosstalk between intrinsic and extrinsic factors that are crucial for proper thyroid development, with various signaling pathways playing important roles in the commitment of endodermal cells to a thyroid fate during specific developmental windows in the zebrafish embryo.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Ankit Pandey, Helene Cousin, Brett Horr, Dominique Alfandari
Summary: This study discovered that the non-proteolytic ADAM11 maintains the naive cell state through promoting BMP4 signaling and repressing Wnt signaling. Loss of ADAM11 leads to increased Wnt signaling, increased cell proliferation, and early epithelial to mesenchymal transition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Huan Wu, Guangfu Yin, Ximing Pu, Juan Wang, Xiaoming Liao, Zhongbing Huang
Summary: This study demonstrated the inhibitory effects of BMP-2, VEGF, and bFGF on osteoclasts when used in combination, suggesting new insights for bone repair and regeneration.
TISSUE ENGINEERING PART A
(2021)
Article
Engineering, Biomedical
Yoshifumi Kobayashi, Julie Nouet, Erdenechimeg Baljinnyam, Zain Siddiqui, Daniel H. Fine, Diego Fraidenraich, Vivek A. Kumar, Emi Shimizu
Summary: This study successfully replicated the characteristics of dental pulp tissue using cranial neural crest-like cells (CNCLCs) and demonstrated the potential of fibroblast growth factors (FGFs) in promoting the differentiation of CNCLCs into odontoblasts.
BIOACTIVE MATERIALS
(2022)
Review
Anatomy & Morphology
Gerard A. Tarulli, Samuel M. Cripps, Andrew J. Pask, Marilyn B. Renfree
Summary: The formation of external genitalia is a complex developmental process involving various signaling factors and cell types, controlled by the androgen receptor. Understanding interactions between different cell types and global regulatory networks is crucial for understanding development patterns.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Chemistry, Medicinal
Yanlin Tan, Xiaobin Wang, Yi Zhang, Zhehao Dai, Jing Li, Chuning Dong, Xingwang Yao, Chang Lu, Fei Chen
Summary: This study found that circFGFBP1 was downregulated in intervertebral disc degeneration (IVDD), and upregulation of circFGFBP1 inhibited apoptosis and extracellular matrix (ECM) degradation, and promoted proliferation in IVDD cells. Furthermore, circFGFBP1 upregulation protected NP tissue and the intervertebral disc structure in vivo during IVDD.
Article
Developmental Biology
Tanushree Pandit, Vijay K. Jidigam, Cedric Patthey, Lena Gunhaga
Article
Anatomy & Morphology
Ricardo Lara-Ramirez, Cedric Patthey, Sebastian M. Shimeld
DEVELOPMENTAL DYNAMICS
(2015)
Article
Biology
Vijay K. Jidigam, Raghuraman C. Srinivasan, Cedric Patthey, Lena Gunhaga
Article
Developmental Biology
Cedric Patthey, Harry Clifford, Wilfried Haerty, Chris P. Ponting, Sebastian M. Shimeld, Jo Begbie
NEURAL DEVELOPMENT
(2016)
Article
Developmental Biology
Tamilarasan K. Panaliappan, Walter Wittmann, Vijay K. Jidigam, Sara Mercurio, Jessica A. Bertolini, Soufien Sghari, Raj Bose, Cedric Patthey, Silvia K. Nicolis, Lena Gunhaga
Article
Developmental Biology
Cedric Patthey, Thomas Edlund, Lena Gunhaga
Article
Developmental Biology
Gerhard Schlosser, Cedric Patthey, Sebastian M. Shimeld
DEVELOPMENTAL BIOLOGY
(2014)
Article
Developmental Biology
Cedric Patthey, Gerhard Schlosser, Sebastian M. Shimeld
DEVELOPMENTAL BIOLOGY
(2014)
Review
Oncology
Cedric Patthey, Lena Gunhaga
EXPERIMENTAL CELL RESEARCH
(2014)
Article
Multidisciplinary Sciences
Cedric Patthey, Yong Guang Tong, Christine Mary Tait, Sara Ivy Wilson
SCIENTIFIC REPORTS
(2017)
Article
Developmental Biology
Ricardo Lara-Ramirez, Carlos Perez-Gonzalez, Chiara Anselmi, Cedric Patthey, Sebastian M. Shimeld
Article
Cell Biology
Tamilarasan K. Palaniappan, Lina Slekiene, Lena Gunhaga, Cedric Patthey
Article
Multidisciplinary Sciences
Vasileios Papadogiannis, Alessandro Pennati, Hugo J. Parker, Ute Rothbacher, Cedric Patthey, Marianne E. Bronner, Sebastian M. Shimeld
Summary: This study investigates the role of the Hmx gene in the development of sensory ganglia in vertebrates. The results demonstrate the conservation of regulatory and functional properties of Hmx between Ciona and vertebrates, and suggest that bipolar tail neurons might be homologous to cranial sensory ganglia.
Article
Cell Biology
Ricardo Lara-Ramirez, Guillaume Poncelet, Cedric Patthey, Sebastian M. Shimeld
DEVELOPMENT GENES AND EVOLUTION
(2017)