Article
Immunology
Hi-Joon Park, Sora Ahn, Hyangsook Lee, Dae-Hyun Hahm, Kyuseok Kim, Mijung Yeom
Summary: Acupuncture has been shown to effectively reduce itch symptoms in atopic dermatitis patients, potentially by blocking serotonin receptors to alleviate acute and chronic itch as well as skin inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Jilun Feng, Mu Yang, Dingge Cui, Zhi Huang, Tuo Ji, Yajun Lian
Summary: This study aimed to investigate the factors influencing or predicting the probability of recurrence of anti-NMDAR encephalitis in central China. The results showed that brainstem lesions and ≥3 abnormal sites on brain MRI were significantly associated with an increased risk of recurrence.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alejandro Quintero-Villegas, Sergio Ivan Valdes-Ferrer
Summary: 5-HT7 receptors are the most recently identified among serotonin receptors, and their role in neurodegenerative diseases is not fully understood. This review discusses the signaling pathways and cellular mechanisms involved in 5-HT7R activation, as well as the potential therapeutic implications of pharmacological interventions for 5-HT7R signaling in neurodegeneration.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyu Ma, Chen Chen, Yaxin Lu, Ling Fang, Baohua Cao, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: This study found that serum levels of GSDMD are elevated in patients with anti-NMDAR encephalitis and are associated with disease prognosis. After treatment, GSDMD levels decreased and clinical symptoms improved in patients, indicating a potential role of GSDMD in monitoring and predicting disease progression of anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Immunology
Fanshi Zhang, Mei Liu, Jinmei Tuo, Li Zhang, Jun Zhang, Changyin Yu, Zucai Xu
Summary: This article reviews how neuroinflammation mediates the development of levodopa-induced dyskinesia (LID) through the regulation of NMDA receptors. It also evaluates the potential of common anti-inflammatory drugs and NMDA receptor antagonists to mitigate the development of LID by regulating central neuroinflammation, providing a new theoretical basis for finding new therapeutic targets for LID.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Article
Clinical Neurology
Yingzhe Shao, Juan Du, Yajun Song, Yanfei Li, Lijun Jing, Zhe Gong, Ranran Duan, Yaobing Yao, Yanjie Jia, Shujie Jiao
Summary: This study aimed to explore the difference in coagulation function between healthy individuals and patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and its relationship with disease severity. The results showed that serum D-dimer and neutrophil levels were independent predictors of disease severity in patients with first-attack anti-NMDAR encephalitis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Qianhui Xu, Qian Wang, Jing Han, Fengju Mao, Silin Zeng, Siyan Chen, Chenyong Zhao, Mei Gu, Zaiwang Li, Xuejun Fu, Xiaoguang Luo, Ying Huang
Summary: Central hypoventilation at admission is a key risk factor for mechanical ventilation during hospitalization in patients with anti-NMDAR encephalitis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Sara de la Salle, Dhrasti Shah, Joelle Choueiry, Hayley Bowers, Judy McIntosh, Brooke Carroll, Vadim Ilivitsky, Verner Knott
Summary: This study demonstrated that ketamine administration affected P300 in healthy volunteers, with reductions in novelty processing P300 and negative correlations with dissociation symptoms. These findings suggest a potential role of NMDAR dysfunction in disrupted auditory attention in schizophrenia.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Tuo Ji, Zhi Huang, Yajun Lian, Chengze Wang, Qiaoman Zhang
Summary: This study investigated the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. The findings suggest that low FT3 levels upon admission may be associated with more severe disease progression and poorer outcomes in these patients. Monitoring FT3 levels could potentially aid in clinical prediction and decision-making in the treatment of anti-NMDAR encephalitis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Stefan Macher, Tobias Zrzavy, Romana Hoeftberger, Patrick Altmann, Ekatarina Pataraia, Fritz Zimprich, Thomas Berger, Paulus Rommer
Summary: CSF-NfL levels in anti-NMDARE patients do not predict short-term outcomes, but are associated with ICU stay and extreme delta brushes. High CSF-NfL levels are associated with long-term outcomes, suggesting early aggressive immunotherapy to prevent neuroaxonal damage.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Oskar Stevens-Jones, Hana Mojzisova, Martin Elisak, Radu Constantinescu, Jitka Hanzalova, Markus Axelsson, David Krysl
Summary: This study aimed to discover clinically relevant biomarkers in NMDAR and LGI1 encephalitis using a proteomic approach. The results showed that SIRT2 may serve as a biomarker for NMDAR encephalitis and be associated with ovarian teratoma.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jingjie Ge, Bo Deng, Yihui Guan, Weiqi Bao, Ping Wu, Xiangjun Chen, Chuantao Zuo
Summary: This study investigated the distinct cerebral metabolic patterns in patients with anti-NMDAR encephalitis triggered by different factors. The results showed that patients in different subgroups exhibited different metabolic patterns, which may contribute to a better understanding of the occurrence and development of the disorder in each subgroup.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Immunology
Yuchen Li, Keyu Yang, Fang Zhang, Jing Wang, Huijun Shen, Miaomiao Liu, Junhong Guo, Jie Wang
Summary: This study identified potential CSF biomarkers for the occurrence, development, and prognosis of anti-NMDAR encephalitis using high-throughput proteomic analysis. The identified biomarkers are associated with immune/inflammatory responses and altered levels of autophagy. These biomarkers show promise in evaluating the severity and prognosis of anti-NMDAR encephalitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Yi-Shiou Tseng, Chun-Hou Liao, Wen-Bin Wu, Ming-Chieh Ma
Summary: The study demonstrates that NMDAR blockade alleviates D-serine-induced renal injury, possibly through the involvement of NOX4-mediated oxidative stress. These findings have important implications for preventing acute renal injury caused by D-serine.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Neurosciences
Edouard Pearlstein, Laurie-Anne Gouty-Colomer, Francois J. Michel, Robin Cloarec, Constance Hammond
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Edouard Pearlstein, Francois J. Michel, Laurene Save, Diana C. Ferrari, Constance Hammond
FRONTIERS IN CELLULAR NEUROSCIENCE
(2016)
Article
Neurosciences
Rejean Dubuc, Frederic Brocard, Myriam Antri, Karine Fenelon, Jean-Francois Gariepy, Roy Smetana, Ariane Menard, Didier Le Ray, Gonzalo Viana Di Prisco, Edouard Pearlstein, Mikhail G. Sirota, Dominique Derjean, Melissa St-Pierre, Barbara Zielinski, Francois Auclair, Danielle Veilleux
BRAIN RESEARCH REVIEWS
(2008)
Article
Pharmacology & Pharmacy
Edouard Pearlstein
CURRENT PHARMACEUTICAL DESIGN
(2013)
Article
Neurosciences
E Pearlstein, F Ben Mabrouk, JF Pflieger, L Vinay
EUROPEAN JOURNAL OF NEUROSCIENCE
(2005)
Review
Behavioral Sciences
F Clarac, E Pearlstein, JF Pflieger, L Vinay
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2004)
Article
Neurosciences
M Le Bon-Jego, D Cattaert, E Pearlstein
JOURNAL OF NEUROSCIENCE
(2004)
Article
Neurosciences
JC Norreel, JF Pflieger, E Pearlstein, J Simeoni-Alias, F Clarac, L Vinay
JOURNAL OF NEUROSCIENCE
(2003)
Article
Neurosciences
L Vinay, F Brocard, F Clarac, JC Norreel, E Pearlstein, JF Pflieger
BRAIN RESEARCH REVIEWS
(2002)
Article
Neurosciences
GV Di Prisco, E Pearlstein, D Le Ray, R Robitaille, R Dubuc
JOURNAL OF NEUROSCIENCE
(2000)
Article
Neurosciences
AHD Watson, M Bevengut, E Pearlstein, D Cattaert
JOURNAL OF COMPARATIVE NEUROLOGY
(2000)
Review
Neurosciences
Francois Clarac, Edouard Pearlstein
BRAIN RESEARCH REVIEWS
(2007)