Article
Clinical Neurology
Duncan Street, W. Richard Bevan-Jones, Maura Malpetti, P. Simon Jones, Luca Passamonti, Boyd C. P. Ghosh, Timothy Rittman, Ian T. S. Coyle-Gilchrist, Kieren Allinson, Catherine E. Dawson, James B. Rowe
Summary: This study aimed to identify structural changes that predict severity and survival in patients with Richardson's syndrome phenotype of progressive supranuclear palsy (PSP). The findings suggest that atrophy in certain brain regions, including the striatum, cerebellum, and frontotemporal cortex, is associated with disease severity and survival. The study highlights the potential of magnetic resonance imaging for prognostication and stratification of PSP patients with different clinical trajectories.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Marina Picillo, Maria Francesca Tepedino, Filomena Abate, Sara Ponticorvo, Roberto Erro, Sofia Cuoco, Nevra Oksuz, Gianfranco Di Salle, Francesco Di Salle, Fabrizio Esposito, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone
Summary: This study evaluated the asymmetry in motor and higher cortical features in PSP-RS patients and found that these features were commonly asymmetric in PSP-RS. There was also a greater degree of asymmetry in the hemispheres compared to healthy controls. These findings contribute to a better understanding of the characteristics of PSP-RS.
NEUROLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Yafei Wen, Qijie Yang, Bin Jiao, Weiwei Zhang, Jingyi Lin, Yuan Zhu, Qian Xu, Hui Zhou, Ling Weng, Xinxin Liao, Yafang Zhou, Junling Wang, Jifeng Guo, Xinxiang Yan, Hong Jiang, Beisha Tang, Lu Shen
Summary: This study characterized the clinical manifestations, MRI, and longitudinal MRI changes of progressive supranuclear palsy (PSP) in China. The results showed significant differences in clinical symptoms, MRI parameters, and longitudinal MRI changes between PSP-P and PSP-RS. Additionally, some MRI parameters could be potential markers to distinguish PSP-P from Parkinson's disease (PD).
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Jong Hyeon Ahn, Junmo Kwon, Ji Hye Won, Kyoungseob Byeon, Jinyoung Youn, Hyunjin Park, Jin Whan Cho
Summary: This study investigated waiting impulsivity in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) and introduced a novel evaluation method. The results showed that the JTG sign is a surrogate marker of waiting impulsivity in PSP-RS patients, enriching the current understanding of waiting impulsivity in PSP patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Blas Couto, Ivan Martinez-Valbuena, Seojin Lee, Isabel Alfradique-Dunham, Richard J. Perrin, Joel S. Perlmutter, Carlos Cruchaga, Ain Kim, Naomi Visanji, Christine Sato, Ekaterina Rogaeva, Anthony E. Lang, Gabor G. Kovacs
Summary: This study reveals a broader range of disease courses in progressive supranuclear palsy (PSP) than previously known. Time to gait dependence and cognitive impairment are proposed as prognostic milestones. Genetic polymorphisms in TRIM11 and SLC2A13 genes are associated with longer disease duration. The study suggests a subtype of PSP with protracted course and explores its relationship with protein misfolding, seeding activity, and propagation.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Viviana A. Martinez-Villota, Cinthia Terroba-Chambi, Sergio A. Castillo-Torres, Malco Rossi, Marcelo Merello
Summary: This study evaluated the clinical correlates of fear of falling in patients with progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). The findings suggest that mobility, balance, and gait performance, as well as anxiety and depression, are determinants of fear of falling in PSP and MSA, while apathy is a determinant in MSA. These results highlight the importance of a multidisciplinary approach to fear of falling in neurodegenerative atypical parkinsonism.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Koustav Chatterjee, Subhadip Paul, Rebecca Banerjee, Supriyo Choudhury, Mona Tiwari, Purba Basu, Hrishikesh Kumar
Summary: This study compared gait parameters and neuro-morphometric indices between PSP-RS and VaP patients, and found significant differences in stride time, step time, swing time, and stance time between the two groups. Morphometric analyses showed differences in brain volumes, with lower volumes in thalamus and caudate in PSP-RS and higher volumes in cerebellar cortex, hippocampus, amygdala, accumbens, and putamen. Thinner bilateral insula was also observed in VaP. Correlation analyses suggested the involvement of limbic structures in postural control during self-paced walking of PSP-RS patients.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Camilla Calomino, Andrea Quattrone, Alessia Sarica, Maria Giovanna Bianco, Federica Aracri, Marida De Maria, Jolanda Buonocore, Maria Grazia Vaccaro, Basilio Vescio, Aldo Quattrone
Summary: Objective: The study aimed to identify brain structures associated with postural instability (PI) in Progressive Supranuclear Palsy (PSP). Methods: PSP patients and control subjects were evaluated using voxel-based morphometry (VBM). Results: Widespread grey matter atrophy was observed in PSP patients compared to controls. The right inferior frontal gyrus (IFG) was significantly associated with the PI score in PSP patients. Conclusions: The IFG volume may play a role in the pathophysiological mechanisms underlying PI. This finding has important implications for developing optimal treatment protocols for postural disorders in parkinsonism.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Priyanka Tupe-Waghmare, Archith Rajan, Shweta Prasad, Jitender Saini, Pramod Kumar Pal, Madhura Ingalhalikar
Summary: This study demonstrates the feasibility of using radiomics features extracted from T1-weighted MRI images to differentiate Parkinson's disease from atypical parkinsonian syndromes. The results showed high accuracy rates for classifiers distinguishing PD from HC, PD from APS, and a 3-way classifier for PD/MSA/PSP, highlighting the potential of radiomics in aiding clinical diagnosis in early stages of disease.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Mike Wattjes, Hans-Juergen Huppertz, Nima Mahmoudi, Sophia Stoecklein, Sophia Rogozinski, Florian Wegner, Martin Klietz, Ivayla Apostolova, Johannes Levin, Sabrina Katzdobler, Carsten Buhmann, Andrea Quattrone, Georg Berding, Matthias Brendel, Henryk Barthel, Osama Sabri, Guenter Hoeglinger, Ralph Buchert, Alzheimers Dis Neuroimaging Initiat
Summary: This study compared the value of different MRI reading strategies and automatic classification methods in the diagnosis of PSP. The results showed that the fully automatic classification method using support vector machine performed the best, especially in the diagnosis of vPSP. Therefore, it is recommended to use machine learning methods for fully automatic classification in settings with a broad phenotypic PSP spectrum.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Arthur Cassa Macedo, Paulo Caramelli, Elisa de Paula Franca Resende, Luciano Inacio Mariano, Vitor Tumas, Antonio Lucio Teixeira, Sarah Teixeira Camargos, Francisco Eduardo Costa Cardoso, Leonardo Cruz de Souza
Summary: The study found that episodic memory impairment in PSP may be related to the damage of medial temporal structures, rather than solely due to executive dysfunction.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Srikanth Yadav Boini, Rohan Mahale, Seshagiri Doniparthi Venkata, Nitish Kamble, Vikram Holla, Pramod Kumar Pal, Bindu Kutty, Ravi Yadav
Summary: The study investigates the association between oculomotor abnormalities and sleep stages in progressive supranuclear palsy (PSP) using video polysomnography. The results show a significant negative correlation between vertical saccadic restriction and total sleep time and sleep efficiency. The findings suggest that oculomotor and sleep abnormalities are interconnected in PSP.
Article
Medicine, General & Internal
Piotr Alster, Michal Nieciecki, Bartosz Migda, Michal Kutylowski, Natalia Madetko, Karolina Duszynska-Was, Ingeborga Charzynska, Dariusz Koziorowski, Leszek Krolicki, Andrzej Friedman
Summary: This study examined patients with MSA-P and PSP-P, two types of atypical parkinsonism that are difficult to differentiate in the early years of development. The researchers found that extended examination using MRI and perfusion SPECT, focusing on the evaluation of the mesencephalon/pons ratio, mesencephalic volume decrease, MRPI, and frontal perfusion, may be more feasible than cognitive evaluation in the 3-6-year duration of symptoms.
Article
Geriatrics & Gerontology
Sophia Rogozinski, Martin Klietz, Gesine Respondek, Wolfgang H. Oertel, Michel J. Grothe, Joana B. Pereira, Gunter U. Hoglinger
Summary: This study analyzed the gray matter volumes of the nucleus basalis of Meynert (nbM) in different parkinsonian syndromes and investigated their relationship with clinical variables. The results showed that nbM volumes were reduced in patients with PSP and PD, but not in MSA. Furthermore, there were no significant correlations between nbM volumes and cognitive measures.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Katie A. Peterson, Karalyn Patterson, James B. Rowe
Summary: PSP and CBS can present changes in speech and language alongside or before motor symptoms, making their differential diagnosis challenging in the early stages. Language impairment is often an early and persistent issue in CBS and PSP, highlighting the need for improved language screening and detailed language assessments. Improved language assessment may help in differential diagnosis and inform clinical management decisions.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Elisabetta Pagani, Loredana Storelli, Patrizia Pantano, Nikolaos Petsas, Gioacchino Tedeschi, Antonio Gallo, Nicola De Stefano, Marco Battaglini, Maria A. Rocca, Massimo Filippi
Summary: In patients with multiple sclerosis, the determination of brain atrophy in specific regions is clinically relevant. However, analyzing large datasets is challenging due to the increased variability in multicenter data. This study compared different methods to correct for center effects and investigated regional gray matter volume in patients with relapsing-remitting multiple sclerosis using a large multicenter dataset. The results showed that harmonization based on subsampling effectively reduced the residuals of the statistical model applied, and the multicenter results were more robust compared to findings from single-center analysis, highlighting the importance of data repositories from multiple centers.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani, Olga Marchesi, Lorenzo Conti, Andrea Falini, Maria A. Rocca, Massimo Filippi
Summary: Using diffusion tensor and neurite orientation dispersion and density imaging (NODDI), this study found that neuro-axonal damage and loss of microarchitecture integrity in focal WM lesions, NAWM, and GM contribute to cognitive impairment in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Antonio Carotenuto, Paola Valsasina, Paolo Preziosa, Damiano Mistri, Massimo Filippi, Maria A. Rocca
Summary: This study investigates abnormalities in the monoaminergic network of patients with multiple sclerosis (MS) using PET and fMRI techniques. The results show that MS patients exhibit dysregulation in these networks, with specific alterations associated with fatigue and depression. These findings provide potential targets for the treatment of these bothersome symptoms.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Andrea Gardoni, Federica Agosta, Elisabetta Sarasso, Silvia Basaia, Elisa Canu, Michela Leocadi, Veronica Castelnovo, Andrea Tettamanti, Maria Antonietta Volonte, Massimo Filippi
Summary: This study aimed to assess cerebellar atrophy and activity alterations during functional MRI (fMRI) gait-simulating motor- and dual-tasks in Parkinson's disease patients with postural instability and gait disorders (PD-PIGD). The results showed that PD-PIGD patients had reduced volumes of cerebellar motor and non-motor areas and increased activity of cognitive areas during fMRI tasks. These findings suggest that the increased activity of non-motor cerebellar areas may be a compensatory mechanism in response to cerebellar motor dysfunction in PD-PIGD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Matteo Albergoni, Loredana Storelli, Paolo Preziosa, Maria A. Rocca, Massimo Filippi
Summary: This study investigated the association between damage to the insula and cardiovascular fitness (CF) in patients with multiple sclerosis (MS). The results showed that aerobic training (AT) may improve walking capacity and submaximal measure of CF in MS patients, and this beneficial effect may be modulated by insula integrity.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Douglas L. Arnold, Frederik Barkhof, Daniel M. Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G. Weinshenker, Maria A. Rocca
Summary: The use of MRI in the diagnosis of MS has evolved considerably, with the introduction of the 2017 McDonald criteria and new MRI markers. Artificial intelligence tools may complement human assessment in improving diagnosis and patient classification.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Michela Leocadi, Elisa Canu, Angela Paldino, Federica Agosta, Massimo Filippi
Summary: This review aims to define awareness impairment and related disturbances in neurodegenerative diseases and provides an update on the use of MRI in studying awareness in these disorders. It highlights the importance of awareness impairment in AD and FTLD and discusses the application of MRI in investigating different aspects of awareness in these populations.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Giulia Berzero, Valentina Pieri, Pietro Mortini, Massimo Filippi, Gaetano Finocchiaro
Summary: The clinical use of liquid biopsy, specifically the analysis of cell-free DNA from plasma or cerebrospinal fluid, is increasingly important in oncology, particularly for brain tumours. It can provide valuable information for differential diagnosis, patient follow-up, and identifying targetable genetic alterations. However, there are challenges such as concomitant pathologies and invasive procedures to obtain cerebrospinal fluid, which could affect the accuracy and interpretation of the results. Further research and understanding of the mechanisms behind cfDNA shedding by tumours are needed to fully exploit its potential in clinical practice.
Article
Clinical Neurology
Monica Margoni, Elisabetta Pagani, Paolo Preziosa, Mor Gueye, Matteo Azzimonti, Maria A. Rocca, Massimo Filippi
Summary: This study used multimodal MRI to investigate the regional distribution of different pathological processes in the brain white and gray matter of relapse-onset multiple sclerosis (MS) patients. The results showed that compared to healthy controls, relapsing-remitting MS (RRMS) patients exhibited white matter, deep gray matter, and cortical atrophy, as well as significantly lower MTR and T1w/T2w ratio in periventricular and infratentorial white matter, deep gray matter, and several cortical areas. Secondary progressive MS (SPMS) patients showed more severe deep gray matter and widespread cortical atrophy, lower MTR of periventricular white matter, deep gray matter, and cerebellum, lower T1w/T2w ratio of fronto-temporal white matter regions, lower ICV_f of some fronto-tempo-occipital white matter and cortical areas, and increased QSM and T1w/T2w ratio in the pallidum.
JOURNAL OF NEUROLOGY
(2023)
Correction
Clinical Neurology
Chiara Zanetta, Maria A. Rocca, Alessandro Meani, Vittorio Martinelli, Laura Ferre, Lucia Moiola, Massimo Filippi
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Federico Montini, Agostino Nozzolillo, Paola M. V. Rancoita, Chiara Zanetta, Lucia Moiola, Federica Cugnata, Federica Esposito, Maria A. Rocca, Vittorio Martinelli, Massimo Filippi
Summary: This study assessed modifiable risk factors associated with COVID-19 in people with multiple sclerosis (PwMS). The results showed that higher vitamin D levels and active smoking status were associated with a lower risk of COVID-19, while external contact and working in the healthcare sector increased the risk. Therefore, vitamin D supplementation and teleworking may help prevent infection risk in PwMS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Chiara Zanetta, Maria A. Rocca, Alessandro Meani, Vittorio Martinelli, Laura Ferre, Lucia Moiola, Massimo Filippi
Summary: This study investigated the effectiveness and safety of cladribine in RRMS patients. The results showed that cladribine reduced relapses and MRI activity, and stabilized disability. Patients who switched from first-line therapies or were naïve had better outcomes.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Valentina Pieri, Davide Gusmeo Curti, Rosina Paterra, Matteo Azzimonti, Giacomo Sferruzza, Giulia Berzero, Rosalinda Cardamone, Nicoletta Anzalone, Federica Agosta, Francesca Caso, Giuseppe Magnani, Gaetano Finocchiaro, Massimo Filippi
Summary: In this study, liquid biopsy diagnostic method successfully detected somatic mutations associated with gliomas in the patient's cerebrospinal fluid, providing therapeutically targetable mutations. This method can assist in the differential diagnosis of neurological diseases when imaging is not informative enough and surgical biopsy is not feasible.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Paride Schito, Tommaso Russo, Teuta Domi, Alessandra Mandelli, Laura Pozzi, Ubaldo Del Carro, Paola Carrera, Federica Agosta, Angelo Quattrini, Roberto Furlan, Massimo Filippi, Nilo Riva
Summary: The study aims to determine the features at onset that can differentiate between primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS), evaluate the diagnostic performance of a serum biomarker panel, and identify prognostic factors for patients with upper motor neuron syndrome.
Article
Clinical Neurology
Federica Agosta, Edoardo Gioele Spinelli, Silvia Basaia, Camilla Cividini, Francesco Falbo, Costanza Pavone, Nilo Riva, Elisa Canu, Veronica Castelnovo, Giuseppe Magnani, Francesca Caso, Paola Caroppo, Sara Prioni, Cristina Villa, Lucio Tremolizzo, Ildebrando Appollonio, Vincenzo Silani, Keith A. Josephs, Jennifer Whitwell, Massimo Filippi
Summary: This study used a graph theory-based MRI paradigm to explore functional connectivity reorganization in different clinical presentations of frontotemporal dementia (bvFTD, nfvPPA, svPPA), and its relationship with neurodegeneration. The findings revealed that each FTD syndrome is associated with a characteristic interplay of decreased and increased functional connectivity with the disease epicenter, affecting both direct and indirect connections.