Article
Neurosciences
Paolo Scalmani, Rosina Paterra, Massimo Mantegazza, Massimo Avoli, Marco de Curtis
Summary: Single-unit recordings in temporal lobe epilepsy patients and models of temporal lobe seizures showed that interneurons are active during focal seizure onset. This study performed simultaneous patch-clamp and field potential recordings in entorhinal cortex slices of mice to analyze the activity of specific interneuron (IN) subpopulations during acute seizure-like events (SLEs) induced by 4-aminopyridine (4-AP). The results revealed that entorhinal cortex INs are highly active at the onset and during the progression of 4-AP-induced SLEs.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Julia Bukanova, Elena Solntseva, Rodion Kondratenko, Eva Kudova
Summary: Epi is a positive modulator of GABA-induced chloride current (I-GABA) with an EC50 of 5.7 μM in Purkinje cells and 9.3 μM in hippocampal neurons. The potentiation of I-GABA by Epi is more pronounced at low GABA concentrations.
Article
Integrative & Complementary Medicine
Thao Nguyen Thi Phuong, Seon Hui Jang, Santosh Rijal, Woo Kwon Jung, Junghyun Kim, Soo Joung Park, Seong Kyu Han
Summary: The study examined how linalool acted on SG neurons of the Vc in mice, revealing that linalool exhibits GABA- and glycine-mimetic effects. This suggests that linalool can be a promising target molecule for orofacial pain management by activating inhibitory neurotransmission in the SG area of the Vc.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dieter Janzen, Benedikt Slavik, Markus Zehe, Christoph Sotriffer, Helene M. Loos, Andrea Buettner, Carmen Villmann
Summary: This study analyzed the modulatory potential of 11 SQTs at GABA(A) receptors to characterize their potential neurotropic activity. The research found differences in receptor modulation by SQTs in HEK293 cells and neurons, with the presence of gamma(2) and delta subunits being important for SQT modulation. Additionally, the study provided insight into how nutritional digestion can affect the neurotropic potential of natural compounds.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Keke Ren, Haiying Liu, Baolin Guo, Rui Li, Honghui Mao, Qian Xue, Han Yao, Shengxi Wu, Zhantao Bai, Wenting Wang
Summary: The study reveals that quercetin modulates neuronal activity by inhibiting TREK-1 channels, leading to neuroprotective and anti-manic effects. This action is achieved by reducing membrane resistance to increase the excitability threshold of neuronal firing.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Aniello Lombardi, Qiang Wang, Maik C. Stuettgen, Thomas Mittmann, Heiko J. Luhmann, Werner Kilb
Summary: This study investigates the role of short-term synaptic plasticity (STP) in excitatory and inhibitory synapses in the cortical layer 2/3 of mice. The results show that burst stimulation leads to short-term depression (STD) in both excitatory and inhibitory synapses, with stronger depression observed in inhibitory synapses and longer decay time.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Chemistry, Applied
Seon Hui Jang, Soo Joung Park, Kyoung-A Kim, Seong Kyu Han
Summary: The study found that resveratrol directly affects SG neurons of Vc, potentially inhibiting them through the activation of GABA(A) receptors and/or glycine receptors. This suggests that resveratrol could be a promising therapeutic for orofacial pain modulation.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Julia V. Bukanova, Rodion V. Kondratenko, Elena I. Solntseva
Summary: This study investigates the interaction between positive allosteric modulators (PAMs) and competitive antagonists of GABA(A)Rs, demonstrating unblocking effects and revealing an allosteric relationship between these two types of compounds.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Neurosciences
Saishree Badrinarayanan, Frederic Manseau, Sylvain Williams, Mark P. Brandon
Summary: The study reveals varying gradients in electrophysiological and morphological properties of VIP cells in the medial entorhinal cortex (MEC), with differences across layers and along the dorsal-ventral MEC axis. These results characterize the cellular and morphological properties of VIP cells in the MEC.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Marta Jelitai, Albert M. Barth, Ferenc Komlosi, Tamas F. Freund, Viktor Varga
Summary: The study highlights the heterogeneity of GABAergic firing patterns in the MRR, as well as the modulation of their activity by brain states and the fine timescale coupling of spiking to theta and ripple oscillations. Additionally, a correlation between the preferred theta phase and the direction of activity change during ripples was observed, suggesting the segregation of inhibitory neurons into functional groups. The findings also indicate a complementary alteration of non-GABAergic neurons' ripple-coupled activity.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Anesthesiology
Misa Oyama, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe
Summary: Increasing the levels of inhibitory neurotransmitters by blocking their reuptake is a promising therapeutic strategy for relieving chronic pain. In this study, the effects of GABA transporter inhibitors on synaptic transmission in the spinal dorsal horn were investigated. The results showed that GAT1 and GAT3 inhibitors exert distinct GABA(B) receptor-mediated inhibitory effects on excitatory synaptic transmission, contributing to their analgesic effects.
Article
Neurosciences
Ha Thuy Nhung Le, Santosh Rijal, Seon Hui Jang, Seon Ah Park, Soo Joung Park, Won Jung, Seong Kyu Han
Summary: In this study, the effects of honokiol on SG neurons of the Vc were investigated. Honokiol was found to increase the frequency of spontaneous postsynaptic currents by enhancing the release of inhibitory neurotransmitters. It also potentiated glycine- and GABAA receptor-mediated responses and inhibited synaptic transmission in an inflammatory pain model. These findings suggest that honokiol may regulate orofacial pain by modulating neurotransmitter release and synaptic transmission.
Article
Neurosciences
Yun Fei Feng, Yin Yong Zhou, Kai Ming Duan
Summary: Postpartum depression is a serious disease that has a high incidence and severe impact on pregnant women and infants. However, the mechanism of this condition is still unclear. Recent studies have shown that GABA receptors, especially extrasynaptic receptors, are closely associated with postpartum depression. This review focuses on the function of GABA receptors, particularly extrasynaptic receptors, and their association with postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Milica Gusic, Klaus Benndorf, Christian Sattler
Summary: Our study reveals that each occupied binding site contributes to channel activation in P2X7 receptors. While the occupation of a single binding site can activate the channels, three bound ligands maximally stabilize the open state, suggesting a stepwise activation process for P2X7 receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Instruments & Instrumentation
Ian Delgadillo Bonequi, Abraham Stroschein, Lucas J. Koerner
Summary: This article describes a custom and open-source FPGA-based data acquisition system that is used for electrophysiology and closed-loop feedback experiments. The system combines FPGA acquisition and processing with high-speed analog and digital converters to enable real-time feedback. The digital approach simplifies experimental setup and repeatability by allowing for system identification and in situ tuning of filter bandwidths.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Plant Sciences
Yaowaporn Sangsen, Thongchai Sooksawate, Kittisak Likhitwitayawuid, Boonchoo Sritularak, Ruedeekorn Wiwattanapatapee
Article
Neurosciences
Thongchai Sooksawate, Yuchio Yanagawa, Tadashi Isa
EUROPEAN JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Thongchai Sooksawate, Kaoru Isa, Tadashi Isa
JOURNAL OF NEUROPHYSIOLOGY
(2008)
Article
Multidisciplinary Sciences
Naoko Nisimaru, Chetan Mittal, Yoshinori Shirai, Thongchai Sooksawate, Prabu Anandaraj, Tsutomu Hashikawa, Soichi Nagao, Akiko Arata, Takeshi Sakurai, Miyuki Yamamoto, Masao Ito
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Neurosciences
Thongchai Sooksawate, Kaoru Isa, Ryosuke Matsui, Shigeki Kato, Masaharu Kinoshita, Kenta Kobayashi, Dai Watanabe, Kazuto Kobayashi, Tadashi Isa
FRONTIERS IN NEURAL CIRCUITS
(2013)
Article
Neurosciences
Kaoru Isa, Thongchai Sooksawate, Kenta Kobayashi, Kazuto Kobayashi, Peter Redgrave, Tadashi Isa
Article
Multidisciplinary Sciences
Chayapol Tungphatthong, Santhosh Kumar J. Urumarudappa, Supita Awachai, Thongchai Sooksawate, Suchada Sukrong
Summary: This study reveals that DNA barcoding coupled with HRM is an efficient tool with which to identify M. speciosa and M. speciosa-containing samples and ensure the safety and quality of traditional Thai herbal medicines.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Psyche H. Lee, Thongchai Sooksawate, Yuchio Yanagawa, Kaoru Isa, Tadashi Isa, William C. Hall
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2007)
Article
Neurosciences
Thongchai Sooksawate, Tadashi Isa
EUROPEAN JOURNAL OF NEUROSCIENCE
(2006)
Article
Neurosciences
T Sooksawate, Y Saito, T Isa
NEUROSCIENCE RESEARCH
(2005)
Article
Pharmacology & Pharmacy
T Sooksawate, MA Simmonds
BRITISH JOURNAL OF PHARMACOLOGY
(2001)
Article
Neurosciences
T Sooksawate, MA Simmonds