Article
Food Science & Technology
Lei Wang, Shengyu Li, Yu Jiang, Zijian Zhao, Yunjiao Shen, Junjie Zhang, Lei Zhao
Summary: Probiotic Lactobacillus plantarum DP189 has a significant protective effect on the dopaminergic neurons in the substantia nigra of Parkinson's disease mice, improving behavioral abilities and increasing neurotransmitter levels.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Yunjie Rong, Zhifeng Xu, Ye Zhu, Xianhai Zhang, Lingfeng Lai, Shuyi Sun, Mingyong Gao, Pi Guo, Guohua Zhang, Yiqun Geng, Xilun Ma, Shuohua Wu, Lin Yang, Zhiwei Shen, Jitian Guan
Summary: This study identified changes in iron deposition and neural microstructure in the substantia nigra as potential indicators of early-stage Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Boliang Yu, Ling Li, Xiaojun Guan, Xiaojun Xu, Xueling Liu, Qing Yang, Hongjiang Wei, Chuantao Zuo, Yuyao Zhang
Summary: The study introduces a HybraPD atlas using QSM and T1w images from PD patients, providing templates and manually delineated subcortical nuclei for more accurate segmentation related to PD pathology. This atlas offers a more precise tool for studying brain pathological alterations in subcortical regions for PD research.
HUMAN BRAIN MAPPING
(2021)
Article
Biochemistry & Molecular Biology
Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo
Summary: This study suggests a potential association between reduced ITGA7 expression and increased alpha-syn expression and apoptosis of dopaminergic cells in an MPTP-induced PD mouse model. This is the first study to show a link between ITGA7 and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Anne Lotz, Beate Pesch, Swaantje Casjens, Martin Lehnert, Wolfgang Zschiesche, Dirk Taeger, Chien-Lin Yeh, Tobias Weiss, Tobias Schmidt-Wilcke, Clara Quetscher, Stefan Gabriel, Maria Angela Samis Zella, Dirk Woitalla, Ulrike Dydak, Christoph van Thriel, Thomas Bruening, Thomas Behrens
Summary: The study found that welders exposed to manganese showed normal fine motor functions, excelling in steadiness tests but slightly slower in motor tests compared to controls. MRI-based biomarkers did not show a correlation between fine motor test results and the levels of manganese deposition in the brain.
Article
Neurosciences
Alipi Bonm, Izaskun Elezgarai, Christina M. Gremel, Katie Viray, Nigel S. Bamford, Richard D. Palmiter, Pedro Grandes, David M. Lovinger, Nephi Stella
Summary: The study shows that CB1R expressed by MSNs play a crucial role in controlling exploration, motor coordination, and amphetamine sensitization. However, the effects on certain behaviors may only be partially or fully rescued.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Nicholas N. Foster, Joshua Barry, Laura Korobkova, Luis Garcia, Lei Gao, Marlene Becerra, Yasmine Sherafat, Bo Peng, Xiangning Li, Jun-Hyeok Choi, Lin Gou, Brian Zingg, Sana Azam, Darrick Lo, Neda Khanjani, Bin Zhang, Jim Stanis, Ian Bowman, Kaelan Cotter, Chunru Cao, Seita Yamashita, Amanda Tugangui, Anan Li, Tao Jiang, Xueyan Jia, Zhao Feng, Sarvia Aquino, Hyun-Seung Mun, Muye Zhu, Anthony Santarelli, Nora L. Benavidez, Monica Song, Gordon Dan, Marina Fayzullina, Sarah Ustrell, Tyler Boesen, David L. Johnson, Hanpeng Xu, Michael S. Bienkowski, X. William Yang, Hui Gong, Michael S. Levine, Ian Wickersham, Qingming Luo, Joel D. Hahn, Byung Kook Lim, Li Zhang, Carlos Cepeda, Houri Hintiryan, Hong-Wei Dong
Summary: The study reveals a complex structure in the brain, with 29 functional domains transmitting information through multiple channels, influencing cognition, sensorimotor behavior, and the development of various neurological and neuropsychiatric disorders.
Article
Neurosciences
Ziying Yu, Lishuang Huang, Yinyin Xia, Shuqun Cheng, Cantao Yang, Chengzhi Chen, Zhen Zou, Xiaoliang Wang, Xin Tian, Xuejun Jiang, Lixiao Zhou
Summary: Parkinson's disease (PD) is a neurodegenerative disorder in which m6A modification may play a role. By establishing a PD mouse model, researchers found abnormalities in m6A regulators in learning, memory, and motor functions, as well as significant loss of TH+ neurons in the substantia nigra and striatum.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You, Jun Gao
Summary: In this study, it was found that Maged1 was expressed in the dopaminergic neurons of the substantia nigra in mice and humans, which could be upregulated by the treatment with MPTP or MPP+. The study also revealed that Maged1 deficiency protected against motor deficits, loss of DA neurons, and disease progression induced by MPTP. Moreover, Maged1 deficiency enhanced autophagy and inhibited apoptosis, providing a potential target for the therapy of PD.
Article
Clinical Neurology
Tushar Kamath, Evan Z. Macosko
Summary: Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. Recent advances in genomic profiling have identified specific pathways and genetic variants involved in the susceptibility of dopaminergic neurons in Parkinson's disease. This provides new opportunities for understanding and developing therapies for this complex disorder.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Wenbin Gu, Chen He, Juping Chen, Junchen Li
Summary: This study found significant metabolic changes in globus pallidus and substantia nigra during the early stage of Parkinson's disease using magnetic resonance spectroscopy, suggesting that MRS could be a more sensitive imaging biomarker in the diagnosis of early-stage PD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Marta Gonzalez-Sepulveda, Joan Compte, Thais Cuadros, Alba Nicolau, Camille Guillard-Sirieix, Nuria Penuelas, Marina Lorente-Picon, Annabelle Parent, Jordi Romero-Gimenez, Joana M. Cladera-Sastre, Ariadna Laguna, Miquel Vila
Summary: Neurons that accumulate the highest levels of neuromelanin with age are also the most susceptible to degeneration in Parkinson's disease. Using a neuromelanin-producing rat model, Gonzalez-Sepulveda, Compte et al. show that slowing down age-dependent neuromelanin production can help prevent Parkinson's disease-like features.
Article
Cell Biology
Ya- Wei Ji, Xue Zhang, Jiang-Peng Fan, Wei-Xin Gu, Zi-Lin Shen, Hai-Chuan Wu, Guiyun Cui, Chunyi Zhou, Cheng Xiao
Summary: The subthalamic nucleus (STN) controls basal ganglia outputs via the substantia nigra pars reticulata (SNr) and the globus pallidus internus (GPi). The STN-SNr and STN-GPi projections differ in synaptic properties and activity-dependent plasticity. Stimulation of either STN projection reduces locomotion; in contrast, inhibition of either the STN-SNr projection or collateral STN neurons facilitates locomotion. In 6-OHDA-hemiparkinsonian mice, the STN-SNr projection is attenuated, but the STN-GPi projection is enhanced; inhibition of the STN-GPi projection through D2 receptors improves locomotion.
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Behavioral Sciences
Zafar U. Khan, E. Chris Muly
BEHAVIOURAL BRAIN RESEARCH
(2011)
Review
Biochemistry & Molecular Biology
Zafar U. Khan, Elisa Martin-Montanez, Mark G. Baxter
CELLULAR AND MOLECULAR LIFE SCIENCES
(2011)
Article
Pharmacology & Pharmacy
Zafar U. Khan, Elisa Martin-Montanez, E. Chris Muly
CURRENT PHARMACEUTICAL DESIGN
(2013)
Article
Neurosciences
Adriana Galvan, Xing Hu, Karen S. Rommelfanger, Jean-Francois Pare, Zafar U. Khan, Yoland Smith, Thomas Wichmann
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Neurosciences
Juan F. Lopez-Tellez, Manuel F. Lopez-Aranda, Irene Navarro-Lobato, Mariam Masmudi-Martin, Elisa Martin Montanez, Eduardo Blanco Calvo, Zafar U. Khan
JOURNAL OF NEUROSCIENCE
(2010)
Article
Biochemistry & Molecular Biology
Mariam Masmudi-Martin, Irene Navarro-Lobato, Manuel F. Lopez-Aranda, Gloria Delgado, Elisa Martin-Montanez, Maria E. Quiros-Ortega, Marta Carretero-Rey, Lucia Narvaez, Maria F. Garcia-Garrido, Sinforiano Posadas, Juan F. Lopez-Tellez, Eduardo Blanco, Inmaculada Jimenez-Recuerda, Pablo Granados-Duran, Jose Paez-Rueda, Juan C. Lopez, Zafar U. Khan
Article
Neurosciences
Irene Navarro-Lobato, Mariam Masmudi-Martin, Manuel F. Lopez-Aranda, Maria E. Quiros-Ortega, Marta Carretero-Rey, Maria F. Garcia-Garrido, Carmen Gallardo-Martinez, Elisa Martin-Montanez, Celia Gaona-Romero, Gloria Delgado, Laura Torres-Garcia, Javier Terron-Melguizo, Sinforiano Posadas, Lourdes Rodriguez Munoz, Carlos Vivar Rios, Jerome Zoidakis, Antonia Vlahou, Juan C. Lopez, Zafar U. Khan
Summary: The expression of RGS14(414) in the perirhinal cortex of rats enhances object recognition memory (ORM) by upregulating 14-3-3 zeta and promoting BDNF protein levels and neuronal structural plasticity. RGS14(414) treatment also prevents deficits in recognition, spatial, and temporal memory in rodent models of aging and Alzheimer's disease.
Article
Neurosciences
Irene Navarro-Lobato, Mariam Masmudi-Martin, Maria E. Quiros-Ortega, Celia Gaona-Romero, Marta Carretero-Rey, Cristina Rey Blanes, Zafar U. Khan
Summary: By overexpressing a memory enhancer called RGS14(414) in the perirhinal cortex of male rats, object recognition memory (ORM) was enhanced and short-term ORM was converted into long-term ORM within a key temporal window of 40 to 60 minutes post-exposure. During this conversion, 14-3-3 zeta upregulation facilitated the process, while beyond 60 minutes, it mediated the consolidation of stable memory into long-lasting ORM by regulating BDNF signaling.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Neurosciences
Jose Antonio Camacho-Conde, Maria del Rosario Gonzalez-Bermudez, Marta Carretero-Rey, Zafar U. Khan
Summary: Brain stimulation has become a widely accepted therapeutic approach in recent years, with non-invasive techniques like rTMS and tDCS, as well as invasive techniques like DBS, being commonly used to treat various neurological disorders. Technological advancements have led to the development of precise devices capable of producing well-controlled and effective brain stimulation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Neurosciences
Jose Antonio Camacho-Conde, Maria del Rosario Gonzalez-Bermudez, Marta Carretero-Rey, Zafar U. Khan
Summary: Brain stimulation, both noninvasive and invasive, has emerged as a valuable therapeutic tool for treating brain diseases. With advancements in technology, techniques such as rTMS, tDCS, and DBS have shown potential in the treatment of mental, psychiatric, and cognitive disorders.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biology
Irene Navarro Lobato, Adrian Aleman-Zapata, Anumita Samanta, Milan Bogers, Shekhar Narayanan, Abdelrahman Rayan, Alejandra Alonso, Jacqueline Van der Meij, Mehdi Khamassi, Zafar U. Khan, Lisa Genzel
Summary: This study found that increasing plasticity in the prelimbic cortex of the brain improves one-trial memory but also leads to increased interference in semantic-like memory. Additionally, this manipulation results in shorter non-REM sleep bouts, smaller delta-waves, and decreased neuronal firing rates. In contrast, interactions between the hippocampus and cortex during wake and REM sleep, as well as oscillatory coupling during non-REM sleep, are enhanced.
Article
Neurosciences
Mariam Masmudi-Martin, Irene Navarro-Lobato, Manuel F. Lopez-Aranda, Philip G. F. Browning, Ana-Maria Simon, Juan F. Lopez-Tellez, Inmaculada Jimenez-Recuerda, Elisa Martin-Montanez, Alberto Perez-Mediavilla, Diana Frechilla, Mark G. Baxter, Zafar U. Khan
Meeting Abstract
Pharmacology & Pharmacy
M. Masmudi-Martin, I Navarro-Lobato, E. Castilla-Ortega, E. Martin-Montanez, M. Dominguez-Pinos, Baron Lopez F, Cuadros Romero M, L. Santin, J. Pavia, Z. Khan
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2011)
Meeting Abstract
Pharmacology & Pharmacy
I Navarro-Lobato, M. Lopez-Aranda, M. Masmudi-Martin, J. Lopez-Tellez, S. Posadas, G. Delgado, E. Martin-Montanez, E. Blanco Calvo, J. Pavia, Z. Khan
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2011)
Meeting Abstract
Pharmacology & Pharmacy
I Navarro-Lobato, M. Masmudi-Martin, M. Lopez-Aranda, S. Luna-Valero, J. Barco Collazos, V Campos, I Santos, J. Luque, Z. Khan
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2011)