期刊
EUROPEAN JOURNAL OF NEUROSCIENCE
卷 32, 期 12, 页码 2087-2095出版社
WILEY
DOI: 10.1111/j.1460-9568.2010.07525.x
关键词
growth hormone; in vivo imaging; pituitary; vessels
资金
- Agence Nationale de la Recherche (ANR)
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
- University of Montpellier 1
- University of Montpellier 2
- National Biophotonics and Imaging Platform (Ireland) (NBIPI)
- Fondation pour la Recherche Medicale (FRM)
- Reseau National des Genopoles
- Institut Federatif de Recherches
- Region Languedoc Roussillon
The pulsatile release of hormone is obligatory for the control of a range of important body homeostatic functions. To generate these pulses, endocrine organs have developed finely regulated mechanisms to modulate blood flow both to meet the metabolic demand associated with intense endocrine cell activity and to ensure the temporally precise uptake of secreted hormone into the bloodstream. With a particular focus on the pituitary gland as a model system, we review here the importance of the interplay between blood flow regulation and oxygen tensions in the functioning of endocrine systems, and the known regulatory signals involved in the modification of flow patterns under both normal physiological and pathological conditions.
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