Article
Pharmacology & Pharmacy
Wen Liu, Aaron R. Rohlman, Ryan Vetreno, Fulton T. Crews
Summary: The study found that adolescent binge drinking affects adult OL markers in PFC regions, while also impacting OPC marker expression; furthermore, these effects could lead to lasting changes in PFC function.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Daniel Reyes-Haro, Abraham Cisneros-Mejorado, Rogelio O. Arellano
Summary: Oligodendrocytes play a crucial role in brain connectivity by producing myelin for insulating axons. Myelin repair relies on the differentiation of new oligodendrocytes from precursor cells to preserve and remodel myelin. Neuron-glia communication through GABA signaling in OPCs is important for myelin plasticity and repair.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Na Zhao, Wenhui Huang, Bogdan Catalin, Anja Scheller, Frank Kirchhoff
Summary: NG2 glia are essential proliferating cells in the CNS that can differentiate into oligodendrocytes and regulate homeostasis through secretion of growth factors and cytokines. L-type VGCCs in NG2 glia play a crucial role in cell proliferation and proper structural organization of nodes of Ranvier, while not affecting differentiation and myelin compaction. Additionally, L-type VGCCs contribute to the regulation of long-term neuronal plasticity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Irena Smaga
Summary: This review summarizes the current knowledge on the role of myelin-related changes in depression, as well as the relationship among maternal malnutrition, myelination, and depression. The findings suggest that myelin alterations play a significant role in the development of depression.
Article
Neurosciences
Aline Timmermann, Dario Tascio, Ronald Jabs, Anne Boehlen, Catia Domingos, Magdalena Skubal, Wenhui Huang, Frank Kirchhoff, Christian Henneberger, Andras Bilkei-Gorzo, Gerald Seifert, Christian Steinhaeuser
Summary: NG2 glia is a unique type of macroglial cells in the CNS that receive synaptic input from neurons. Dysfunction in NG2 glia has been found to improve spatial memory but has no effect on social memory. Loss of the K+ channel Kir4.1 in NG2 glia leads to enhanced synaptic depolarizations and expression of myelin basic protein in the hippocampus. Targeted deletion of the K+ channel in NG2 glia impairs long-term potentiation at CA3-CA1 synapses, which can be rescued by extracellular application of a TrkB receptor agonist. These findings highlight the importance of proper NG2 glia function in brain function and behavior.
Review
Neurosciences
Terry Dean, Javid Ghaemmaghami, John Corso, Vittorio Gallo
Summary: Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide, with no targeted therapies available. The functions and mechanisms of NG2-glia, the largest population of regenerative cells in the mature cortex, are not well understood in the context of TBI. This study synthesizes results from multiple rodent models and proposes future avenues for exploring the role of NG2-glia in TBI, suggesting that targeting these cells may enhance local cellular recovery.
Review
Neurosciences
Lucila Perez-Gianmarco, Begum Kurt, Maria Kukley
Summary: This review focuses on the technical approaches used to study AMPARs in oligodendrocyte lineage cells and discusses future perspectives for AMPAR research in glial cells.
Article
Neurosciences
Sheng Zhang, Yan Wang, Jie Xu, Bokyung Kim, Wenbin Deng, Fuzheng Guo
Summary: This study reveals the important role of HIF-alpha in developmental myelination, demonstrating its requirement in controlling OPC differentiation for efficient myelination. Contrary to previous beliefs, it was found that HIF-alpha's regulation of CNS myelination is independent of canonical Wnt signaling, and instead involves the HIF-alpha-Sox9 regulatory axis. This discovery represents a shift in understanding the mechanisms of HIF-alpha-regulated CNS myelination from a Wnt-dependent view to a Wnt-independent one.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Muhammad Irfan, Kirsten S. Evonuk, Tara M. DeSilva
Summary: Microglia play a crucial role in normal brain development by engulfing oligodendrocyte progenitor cells and regulating axon ensheathment to influence circuit development. Their unique amoeboid morphology undergoes changes over time, engulfing OPCs during a critical period to maintain proper myelin sheath ratios.
Review
Neurosciences
Christophe Galichet, Richard W. Clayton, Robin Lovell-Badge
Summary: Oligodendrocyte progenitor cells (OPCs), also known as NG2-glia, play diverse roles in the adult central nervous system, such as serving as progenitors for oligodendrocytes, regulating metabolic environment, maintaining the blood-brain barrier, and modulating inflammation. Advanced techniques have uncovered functional and spatial heterogeneity of OPCs, interactions with other cell types, and responses to signals from neighboring cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min-Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang-Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim, Hwan Tae Park
Summary: The study found that a large population of central neurons are derived from Cnp-expressing neuroglial stem cells; conditional gene targeting using the Cnp promoter, known to be OL-specific, can induce neuron-autonomous phenotypes.
Review
Neurosciences
Christopher D. Fekete, Akiko Nishiyama
Summary: Myelination is crucial for fast action potential conduction, and recent studies have shown that it is a dynamic process that continues throughout adulthood. The synthesis of new myelin requires specific signals to be activated in oligodendrocytes, and these signals are involved in various cellular processes. However, it is still unclear how these signals are provided to oligodendrocyte lineage cells and how they are integrated to produce the correct amount of myelin.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Jaime Eugenin von Bernhardi, Leda Dimou
Summary: This study found that physical activity promotes the proliferation and differentiation of neural stem cells, enhancing neurogenesis and improving cognitive function in the hippocampus. The study also discovered that NG2 glia show enhanced proliferation and differentiation in response to voluntary physical activity, and this differentiation is crucial for the enhancement of cognitive function.
Review
Biochemistry & Molecular Biology
Maria Kukley
Summary: This review discusses recent experimental findings on the functional role of AMPA receptors (AMPARs) in oligodendrocyte lineage cells in vivo, in mice and in zebrafish. The studies showed that oligodendroglial AMPARs may modulate proliferation, differentiation, migration, and survival of oligodendroglial cells. Targeting AMPAR subunit composition could be an important strategy for disease treatment. However, additional research is needed to fully understand the role of AMPARs in vivo, including considering the temporal and spatial aspects of AMPAR-mediated signaling in the oligodendrocyte lineage cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shunqi Wang, Yingxing Wang, Suqi Zou
Summary: This article reviews the process of oligodendrocyte myelination and its regulatory factors, including proliferation, differentiation, and factors influencing myelination.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Behavioral Sciences
Chiara Lucchi, Jonathan Vinet, Stefano Meletti, Giuseppe Biagini
EPILEPSY & BEHAVIOR
(2015)
Article
Genetics & Heredity
Zejuan Li, Rhonda Schonberg, Lucia Guidugli, Amy Knight Johnson, Stephen Arnovitz, Sandra Yang, Joseph Scafidi, Marshall L. Summar, Gilbert Vezina, Soma Das, Kimberly Chapman, Daniela del Gaudio
JOURNAL OF HUMAN GENETICS
(2015)
Article
Neurosciences
Marzieh Zonouzi, Joseph Scafidi, Peijun Li, Brian McEllin, Jorge Edwards, Jeffrey L. Dupree, Lloyd Harvey, Dandan Sun, Christian A. Huebner, Stuart G. Cull-Candy, Mark Farrant, Vittorio Gallo
NATURE NEUROSCIENCE
(2015)
Article
Oncology
Sridevi Yadavilli, Joseph Scafidi, Oren J. Becher, Amanda M. Saratsis, Rebecca L. Hiner, Madhuri Kambhampati, Santi Mariarita, Tobey J. MacDonald, Kari-Elise Codispoti, Suresh N. Magge, Jyoti K. Jaiswal, Roger J. Packer, Javad Nazarian
Review
Pediatrics
Lauren L. Jantzie, Joseph Scafidi, Shenandoah Robinson
PEDIATRIC RESEARCH
(2018)
Article
Oncology
Joseph Scafidi, Jonathan Ritter, Brooke M. Talbot, Jorge Edwards, Li-Jin Chew, Vittorio Gallo
Article
Clinical Neurology
Patrick Mabray, Rapeepat Thewamit, Matthew T. Whitehead, Amy Kao, Joseph Scafidi, William D. Gaillard, Taeun Chang, Tammy N. Tsuchida
Article
Biochemistry & Molecular Biology
S. J. Seguin, F. F. Morelli, J. Vinet, D. Amore, S. De Biasi, A. Poletti, D. C. Rubinsztein, S. Carra
CELL DEATH AND DIFFERENTIATION
(2014)
Article
Biochemistry & Molecular Biology
G. Curia, C. Lucchi, J. Vinet, F. Gualtieri, C. Marinelli, A. Torsello, L. Costantino, G. Biagini
CURRENT MEDICINAL CHEMISTRY
(2014)
Review
Clinical Neurology
Elsa Rossignol, Katja Kobow, Michele Simonato, Jeffrey A. Loeb, Thierry Grisar, Krista L. Gilby, Jonathan Vinet, Shilpa D. Kadam, Albert J. Becker
Article
Multidisciplinary Sciences
Carmela Giordano, Jonathan Vinet, Giulia Curia, Giuseppe Biagini
Review
Neurosciences
Aaron Sathyanesan, Joy Zhou, Joseph Scafidi, Detlef H. Heck, Roy Sillitoe, Vittorio Gallo
NATURE REVIEWS NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Thomas A. Forbes, Evan Z. Goldstein, Jeffrey L. Dupree, Beata Jablonska, Joseph Scafidi, Katrina L. Adams, Yuka Imamura, Kazue Hashimoto-Torii, Vittorio Gallo
NATURE COMMUNICATIONS
(2020)
Article
Biophysics
Chao-Hsiung Hsu, Stephen Lin, Ai-Chen Ho, T. Derek Johnson, Paul C. Wang, Joseph Scafidi, Tsang-Wei Tu
Summary: The study compared the metabolic profiles of mouse hippocampi using proton magnetic resonance spectroscopy (H-1-MRS) in vivo and in situ, with or without focused beam microwave irradiation (FBMI) fixation. The results indicate that a proper fixation method is crucial for in situ detection based on the targeted metabolites of specific interests in the brain.
NMR IN BIOMEDICINE
(2021)
Article
Clinical Neurology
Cheng-Ying Ho, Heather M. Ames, Ashley Tipton, Gilbert Vezina, Judy S. Liu, Joseph Scafidi, Masaaki Torii, Fausto J. Rodriguez, Adre du Plessis, Roberta L. DeBiasi
ANNALS OF NEUROLOGY
(2017)