Article
Behavioral Sciences
Esteban Urrieta, Martha L. Escobar
Summary: Metaplasticity refers to the persistent modification in the ability to induce synaptic plasticity by previous activity, which contributes to network function and cognitive processes. Training in behavioral tasks can modify the possibility of inducing subsequent synaptic plasticity, such as long-term potentiation and depression.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Biochemistry & Molecular Biology
Fubing Han, Fenghua Xu, Qianqian Zhu, Peng Sun, Yu Zhou, Ming Yu
Summary: This study investigates the effect of virus-mediated overexpression of ghrelin receptor GHS-R1a in the basolateral amygdala (BLA) on conditioned taste aversion (CTA) memory processes. The findings reveal that upregulation of GHS-R1a expression in BLA pyramidal neurons represses CTA extinction while it has no effect on CTA acquisition. Additionally, the study shows that local infusion of the endogenous GHS-R1a antagonist LEAP2 abolishes the inhibitory effect of increased GHS-R1a on CTA memory extinction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Fuminori Kawabata, Yuta Yoshida, Yuki Inoue, Yuko Kawabata, Shotaro Nishimura, Shoji Tabata
Summary: The study shows that chickens have a functional fatty acid taste receptor, GPR120, in their oral tissues, but they do not prefer oleic acid solution. Chickens are able to perceive the taste of oleic acid solution, but do not selectively ingest it.
Article
Behavioral Sciences
Antonio D. R. Aguera, Clara Candido, Rocio Donaire, Mauricio R. Papini, Carmen Torres
Summary: This study investigated the behavioral effects of ketamine in animals and found that it increased consummatory suppression and induced conditioned taste aversion to sucrose.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Agriculture, Dairy & Animal Science
Ivonne Cassaigne, Ron Thompson, Richard McKenna, Rodrigo A. Medellin, William Given, Francisco Remolina, Rodrigo Nunez, Diego Woolrich, Fernando Luna
Summary: This study successfully induced conditioned taste aversion in six captive jaguars using Thiabendazole (TBZ), providing an important tool to reduce livestock predation and protect this endangered species.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Neurosciences
Raul Ramos, Chi-Hong Wu, Gina G. Turrigiano
Summary: Generalization is an adaptive mnemonic process that allows animals to use past learning experiences to navigate future scenarios. However, overgeneralization is a characteristic feature of anxiety disorders. This study demonstrates that strong conditioning results in a long-lasting generalized aversion that can persist for at least 2 weeks. The synaptic plasticity mechanisms that govern memory generalization and its persistence are explored, showing that strong conditioning leads to a long-lasting increase in synaptic strengths throughout different layers of the gustatory cortex. Repeated exposure to the generalized tastant causes a rapid attenuation of the generalized aversion and a reversal of the conditioning-induced increases in synaptic strength. These changes are more pronounced in the superficial layers. The data suggest that layer-specific synaptic plasticity mechanisms separately govern the persistence and generalization of memory for conditioned taste aversion.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hiroki Toyoda, Ayano Katagiri, Takafumi Kato, Hajime Sato
Summary: Intranasal administration of rotenone impairs conditioned taste aversion memory in mice by decreasing GABAergic synaptic transmission and causing LTD impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Jiajie Mo, Jianguo Zhang, Wenhan Hu, Lin Sang, Xiaoqiu Shao, Chao Zhang, Kai Zhang
Summary: This study investigated the metabolic and electrophysiological characteristics of temporal lobe LEAT epileptic network using PET and SEEG techniques. Patients with temporal lobe LEAT showed a more widespread epileptic network compared to controls, with significant differences in metabolic patterns.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Jianfeng Liu, Ruyan Wu, Bernard Johnson, Yanan Zhang, Qing Zhu, Jun-Xu Li
Summary: This study found that selective TAAR1 agonists can induce conditioned taste aversion, highlighting the need for careful evaluation before their clinical use in the treatment of mental disorders.
PSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Sarah A. Stern, Estefania P. Azevedo, Lisa E. Pomeranz, Katherine R. Doerig, Violet J. Ivan, Jeffrey M. Friedman
Summary: The insular cortex plays a crucial role in regulating conditioned overconsumption in response to learned cues by controlling a specific circuit, which is active during feeding and suppresses satiety signals in the central amygdala.
Article
Psychology, Biological
Shaoyi Su, Zimo Wei, Helai Huang, Tomohiko Yoshizawa, Tadashi Inui, Makoto Funahashi
Summary: This study aims to investigate the effects of cisplatin and emetine on conditioned taste aversion and demonstrates it using a taste reactivity test in rats. It is found that the readministration of saccharin after gustatory conditioning with cisplatin or emetine induces gaping reactions. The study shows that cisplatin and emetine can induce taste aversion, and it is also observed that gaping reactions almost never occur with intraperitoneal injections of emetine alone.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Jean-Pascal Morin, Emmanuel Rodriguez-Nava, Victor Manuel Torres-Garcia, Omar Alejandro Contreras-Vazquez, Cesar Armando Castellanos-Perez, Jorge Tovar-Diaz, Gabriel Roldan-Roldan
Summary: The sense of taste provides information regarding the nutrient content, safety or potential toxicity of an edible through a combination of innate and learned taste preferences. Recent evidence suggests a role of cholinergic muscarinic signaling in the amygdala for the learning and storage of emotional memories, particularly in conditioned taste aversion.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Futing Zou, Guo Wanjia, Emily J. J. Allen, Yihan Wu, Ian Charest, Thomas Naselaris, Kendrick Kay, Brice A. A. Kuhl, J. Benjamin Hutchinson, Sarah DuBrow
Summary: Using 7T fMRI, the study found that hippocampal area CA1 and the entorhinal cortex predict temporal context memory for scene images by re-expressing activity patterns during subsequent encounters over a period of months. This suggests that CA1 and the entorhinal cortex play a crucial role in preserving temporal memories.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Dai Hatakeyama, Nozomi Chikamoto, Kanta Fujimoto, Takashi Kitahashi, Etsuro Ito
Summary: In this study, the authors compared the results of single-cell qPCR using different quantification and reverse transcription methods. They found that the relative and absolute quantification methods had similar efficacy and validity, but the reverse transcription step significantly influenced mRNA quantification results.
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Majd Bahna, Attila Racz, Inja Ilic, Anna-Laura Potthoff, Tobias Baumgartner, Theodor Rueber, Albert Becker, Alexander Radbruch, Florian Mormann, Rainer Surges, Hartmut Vatter, Matthias Schneider
Summary: This study aimed to evaluate the impact of piriform cortex (PiC) resection on long-term seizure outcome in patients with mesial temporal lobe epilepsy (mTLE) treated with selective amygdalo-hippocampectomy (tsSAHE). The results showed that the extent of PiC resection strongly correlated with long-term seizure outcome, suggesting PiC to be a key target volume in tsSAHE for achieving long-term seizure freedom.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Oscar Salvador Barrera-Vazquez, Juan Carlos Gomez-Verjan, Ricardo Ramirez-Aldana, Paola Garcia-dela Torre, Nadia Alejandra Rivero-Segura
Summary: This study conducted a systematic review of literature from 2015-2021 to analyze and identify the most common microRNAs expressed during acute ischemic stroke (AIS), as well as the pathways, genes, and compounds that influence their expression. The study identified two sets of microRNAs associated with AIS and revealed a network of toxicants and drugs related to AIS for the first time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Kioko Guzman-Ramos, Daniel Osorio-Gomez, Federico Bermudez-Rattoni
Summary: Catecholaminergic transmission plays a vital role in cognitive functions, and plastic changes in learning and memory processes depend heavily on catecholaminergic activity. This review assesses the changes in the catecholaminergic systems involved in the mechanisms underlying cognitive impairment in Alzheimer's disease associated with metabolic dysfunctions.
Article
Neurosciences
Elvi Gil-Lievana, Gerardo Ramirez-Mejia, Oscar Urrego-Morales, Jorge Luis-Islas, Ranier Gutierrez, Federico Bermudez-Rattoni
Summary: Taste memory is stored in the brain through plasticity changes in the neural network, with dopamine playing a critical role. The dopamine pathway from the ventral tegmental area (VTA) to the insular cortex (IC) is necessary for consolidating taste recognition memory.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Lorelei Ayala-Guerrero, Paola Garcia-delaTorre, Sergio Sanchez-Garcia, Kioko Guzman-Ramos
Summary: This study evaluated the value of GFAP as a peripheral biomarker of central dysfunction. The results showed higher levels of serum GFAP in patients with NCD compared to the control group. GFAP levels and T2D were identified as good predictors of NCD risk. This suggests that peripheral GFAP could be used as an objective measurement of central damage and help in the assessment and treatment of cognitive impairment in diabetic patients.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Behavioral Sciences
Daniel Osorio-Gomez, Kioko Guzman-Ramos, Federico Bermudez-Rattoni
Summary: To survive, animals must be able to recognize relevant stimuli and distinguish them from inconspicuous information. Perceptual salience defines how memory integrates inconspicuous stimuli into relevant memory traces without altering physical attributes or valence. Familiarity is important for successful recognition memory. Dopaminergic activity is related to the perceptual salience of stimuli, enabling learning and consolidation processes.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Editorial Material
Medicine, Research & Experimental
Ana Carolina Sepulveda-vildosola, Mardia Lopez-Alarcon, Paola Garcia de la Torre
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Psychology, Biological
Susana Hernandez-Ramirez, Pamela Salcedo-Tello, Daniel Osorio-Gomez, Federico Bermudez-Rattoni, Gustavo Pacheco-Lopez, Guillaume Ferreira, Pauline Lafenetre, Kioko R. Guzman-Ramos
Summary: Childhood and adolescent exposure to obesogenic environments has been linked to various health disorders, including neurocognitive impairment. This study demonstrates that voluntary physical exercise can have a restorative effect on metabolic and cognitive dysfunctions associated with long-term exposure to a high-fat diet.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Donovan K. Galvez-Marquez, Mildred Salgado-Menez, Perla Moreno-Castilla, Luis Rodriguez-Duran, Martha L. Escobar, Fatuel Tecuapetla, Federico Bermudez-Rattoni
Summary: This study found that decreasing catecholamine release from the locus coeruleus terminals in the hippocampus can impact the updating of spatial contextual memory. Photoinhibtion of these terminals impaired the consolidation of object location memory and led to a decrease in both dopamine and noradrenaline levels. This data suggests that dopamine plays a role in the mechanisms of spatial contextual memory updating.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Sergio Sanchez-Garcia, Karla Moreno-Tamayo, Ricardo Ramirez-Aldana, Carmen Garcia-Pena, Raul Hernan Medina-Campos, Paola Garcia dela Torre, Nadia Alejandra Rivero-Segura
Summary: Sleep disorders, including insomnia, are common in aging and have been linked to cognitive decline in older adults. Decreased levels of neurotransmitters, neurohormones, and neurotrophins during the aging process contribute to impaired cognitive function. BDNF, a neurotrophic factor in the brain, has been suggested as a potential target for preventing cognitive decline, but administering exogenous BDNF does not improve cognitive function. A study found that insomnia, not cognitive decline, is significantly associated with BDNF concentration, independent of other variables. This suggests that timely treatment of insomnia may be more beneficial in preventing cognitive decline during aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Oscar Urrego-Morales, Elvi Gil-Lievana, Gerardo Ramirez-Mejia, Luis Francisco Rodriguez-Duran, Martha Lilia Escobar, Ilse Delint-Ramirez, Federico Bermudez-Rattoni
Summary: Protein palmitoylation, mediated by PATs enzymes, regulates various aspects of protein function, including trafficking, mobilization, localization, interaction, and distribution. This process plays a crucial role in modifying synaptic architecture and altering synaptic connections, thereby influencing memory formation and retrieval. In this study, inhibition of PATs in the hippocampus impaired spatial learning, but did not affect memory expression during retrieval. Additionally, inhibiting PATs before electrical stimulation impaired long-term potentiation induction. These findings suggest that PATs activity is essential for neural plasticity, which is required for memory acquisition and consolidation.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Neurosciences
Gerardo Ramirez-Mejia, Elvi Gil-Lievana, Oscar Urrego-Morales, Donovan Galvez-Marquez, Eduardo Hernandez-Ortiz, Jose Alberto Carrillo-Lorenzo, Federico Bermudez-Rattoni
Summary: This study suggests that dopamine released from the ventral tegmental area (VTA) into the insular cortex (IC) is essential for the acquisition and consolidation of object recognition memory. Short-term training can enhance the formation of recognition memory, while long-term training strengthens and stabilizes recognition memory. Interestingly, the activity or motivation to explore objects is not affected by the photostimulation or photoinhibition of the dopaminergic VTA-IC pathway.
Review
Neurosciences
Daniel Osorio-Gomez, Maria Isabel Miranda, Kioko Guzman-Ramos, Federico Bermudez-Rattoni
Summary: Long-term memory is achieved through consolidation and can be updated by new information or prediction errors. This review discusses the neurobiological systems involved in memory updating, including recognition memory and emotional memories. It also examines the potential clinical implications of memory updating in drug addiction, phobias, and post-traumatic stress disorder.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Luis F. Rodriguez-Duran, Diana L. Lopez-Ibarra, Gabriela Herrera-Xithe, Federico Bermudez-Rattoni, Daniel Osorio-Gomez, Martha L. Escobar
Summary: The dopamine and glutamate projections play a crucial role in modulating synaptic plasticity within the insular cortex (IC). Simultaneous stimulation of both dopaminergic and glutamatergic projections can induce long-term potentiation (LTP), which is essential for memory consolidation. The combined effects of dopamine and glutamate are pivotal in the formation of motivational memories.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Cell Biology
Eduardo Hernandez-Ortiz, Jorge Luis-Islas, Fatuel Tecuapetla, Ranier Gutierrez, Federico Bermudez-Rattoni
Summary: The insular cortex modulates the acquisition of drug-related affective states by directly connecting with ventral tegmental area dopamine neurons. Stimulation of VTA terminals in the anterior insular cortex induces rewarding contextual memory and triggers dopamine release within the VTA. Amphetamine administration alters the excitability of VTA neurons modulated by the insular cortex, affecting contextual rewarding behavior.
Article
Neurosciences
Andres Agoitia, Apolinar Cruz-Sanchez, Israela Balderas, Federico Bermudez-Rattoni
Summary: This study investigated the role of the anterior insular cortex (aIC) and its glutamatergic projection to amygdala nuclei (aIC-AMY) in the expression of conditioned place preference (CPP) during early and late abstinence. The results suggest that aIC and aIC-AMY projection play an inhibitory role in CPP expression after late abstinence.
PSYCHOPHARMACOLOGY
(2023)
