Article
Multidisciplinary Sciences
Charles W. Dickey, Anna Sargsyan, Joseph R. Madsen, Emad N. Eskandar, Sydney S. Cash, Eric Halgren
Summary: Research shows that there is a strong tonic and phase-locked increase in firing and co-firing during spindles, especially those occurring with down-to-upstate transitions, within 25 ms. Co-firing, spindle co-occurrence, and spindle coherence are greatest within approximately 2 mm.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Klara Kaleb, Victor Pedrosa, Claudia Clopath
Summary: Despite the stability of neural activity, the aspects conserved and how flexibility for learning and memory is maintained remain not fully understood. Experimental studies suggest the existence of network-centered control in addition to neuron-centered control. Input-dependent inhibitory plasticity (IDIP) can explain various phenomena and provide diverse functional implications in establishing global network balance.
Article
Biology
Ohad Stoler, Alexandra Stavsky, Yana Khrapunsky, Israel Melamed, Grace Stutzmann, Daniel Gitler, Israel Sekler, Ilya Fleidervish
Summary: Mitochondrial activity plays a crucial role in synaptic plasticity, and the firing pattern of pre- and postsynaptic neurons affects mitochondrial function. Our study revealed that postsynaptic spike firing induces rapid mitochondrial Ca2+ responses, with larger responses observed in cell bodies and apical dendrites. Additionally, the coincidence of an EPSP with a backpropagating spike generated prominent mitochondrial Ca2+ hotspots. These findings suggest that mitochondria decode spike firing patterns into Ca2+ signals, which in turn influence metabolic output and may lead to long-term changes in synaptic efficacy.
Article
Neurosciences
Emma Louise Louth, Rasmus Langelund Jorgensen, Anders Rosendal Korshoej, Jens Christian Hedemann Sorensen, Marco Capogna
Summary: The study found that dopamine exerts different modulatory effects on excitatory synaptic plasticity in mouse and human cortical neurons. These results emphasize the importance of dopamine in regulating cognition and may provide insights for therapeutic interventions to recover brain function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Tadaki Koseki, Daisuke Kudo, Kaito Yoshida, Mitsuhiro Nito, Keita Takano, Masafumi Jin, Shigeo Tanabe, Toshiaki Sato, Hiroshi Katoh, Tomofumi Yamaguchi
Summary: This study investigated the excitability of the motor cortex, somatosensory cortex, and spinal motor neurons after the combined stimulation of NMES and tsDCS. The results showed that NMES + tsDCS significantly increased MEP duration and significantly decreased SICI levels.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaokuang Ma, Jing Wei, Yuehua Cui, Baomei Xia, Le Zhang, Antoine Nehme, Yi Zuo, Deveroux Ferguson, Pat Levitt, Shenfeng Qiu
Summary: The study demonstrates that regulation of MET signaling is a key mechanism in controlling cortical circuit development and normal behavior. Prolonged MET signaling alters the molecular composition of synaptic proteins, affects dendritic spine maturation and neural connectivity, leading to developmental abnormalities and impaired behavior in adulthood.
Article
Neurosciences
Chadlia Karoui, Kuzma Strelnikov, Pierre Payoux, Anne-Sophie Salabert, Chris J. James, Olivier Deguine, Pascal Barone, Mathieu Marx
Summary: Cochlear implantation can restore the normal functional pattern of auditory cortical activity and improve sound localization in individuals with asymmetric hearing loss (AHL). The contralateral dominance for the nonimplanted ear strongly correlates with sound localization performance.
Article
Psychology, Biological
Carmenrita Infortuna, Ludovico Mineo, Steven Buffer, Florian P. Thomas, Maria Rosaria Anna Muscatello, Eugenio Aguglia, Antonio Bruno, Rocco Antonio Zoccali, Asad Sheikh, Eileen Chusid, Zhyiong Han, Fortunato Battaglia
Summary: The study found that acute stress can impair homeostatic plasticity in the brain, which may play a crucial role in the pathogenesis of neurological and psychiatric diseases.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Neurosciences
Richard G. Carson, Antonio Capozio, Emmet McNickle, Alexander T. Sack
Summary: The study aimed to determine whether associative effects are induced when the first stimulus of a cortico-cortical pair is tACS or subthreshold TMS. Although both interventions led to sustained increases in corticospinal excitability (approximately 20-30 minutes), the evidence supporting the experimental hypotheses was generally stronger for the paired TMS-TMS condition compared to the tACS-TMS condition.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Audiology & Speech-Language Pathology
Lucilla Vestito, Laura Mori, Carlo Trompetto, Marina Tomatis, Giulia Alessandria, Fabrizio De Carli, Leonardo Cocito, Fabio Bandini
Summary: The Boston Naming Test (BNT) is widely used in clinical practice to detect naming difficulties in patients with language disorders and evaluate semantic memory integrity. This study introduces the first Italian version of the 15-item BNT and provides normative data based on a sample of 275 healthy Italian-speaking adults. The results demonstrate the influence of demographic variables, particularly education, on naming performance.
Article
Food Science & Technology
Carlo Trompetto, Lucio Marinelli, Laura Mori, Luca Puce, Chiara Avanti, Elena Saretti, Giulia Biasotti, Roberta Amella, Filippo Cotellessa, Domenico A. Restivo, Antonio Curra
Summary: This observational study investigated pain in stroke patients with upper limb spastic dystonia. The study found that a significant number of patients experienced pain, and treatment with incobotulinumtoxin-A reduced both pain and muscle tone.
Article
Neurosciences
Lucio Marinelli, Carlo Trompetto, Luca Puce, Fiammetta Monacelli, Laura Mori, Carlo Serrati, Francesco Fattapposta, Maria Felice Ghilardi, Antonio Curra
Summary: Paratonia increases with normal aging and cognitive decline progression. Facilitatory paratonia is due to involuntary contraction of the shortening muscle, while oppositional paratonia is primarily due to involuntary contraction of the lengthening muscle. EMG activity during passive movements correlates with paratonia clinical scores and is velocity-dependent.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Letter
Clinical Neurology
Lucilla Vestito, Laura Mori, Carlo Trompetto, Diego Bagnasco, Rikki F. Canevari, Marta Ponzano, Davide Subbrero, Ester Cecchella, Cristina Barbara, Piero Clavario, Fabio Bandini
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Physiology
Luca Puce, Karim Chamari, Lucio Marinelli, Laura Mori, Marco Bove, Emanuela Faelli, Marco Fassone, Filippo Cotellessa, Nicola Luigi Bragazzi, Carlo Trompetto
Summary: This study compared the effects of drafting in swimming on the drafter in terms of muscle fatigue, muscle activity, and swimming efficiency. The results showed that drafting can reduce muscle fatigue and improve swimming efficiency, with the best effect observed in swimming behind the leader (BD).
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Claudio Solaro, Rachele Di Giovanni, Erica Grange, Giampaolo Brichetto, Margit Mueller, Andrea Tacchino, Rita Bertoni, Francesco Patti, Angelo Pappalardo, Luca Prosperini, Letizia Castelli, Rosalba Rosato, Davide Cattaneo, Davide Marengo
Summary: The study aims to evaluate the associations between Manual Ability Measure-36 (MAM-36) and objective measures, including the Nine Hole Peg Test (9-HPT), Box and Block Test (BBT), and Hand Grip Strength (HGS) in people with multiple sclerosis (PwMS). The study found small correlations between MAM-36 and these objective measures, with different correlations seen in different subgroups. Combining 9-HPT and HGS can enhance the assessment of upper limb function in daily activities.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Michela Ponzio, Maria Cristina Monti, Giulia Mallucci, Paola Borrelli, Sara Fusco, Andrea Tacchino, Giampaolo Brichetto, Livio Tronconi, Cristina Montomoli, Roberto Bergamaschi
Summary: Comorbidity is common in people with multiple sclerosis and can have negative impacts on diagnosis, treatment, and management of the disease. It also has health, social, and economic consequences for these patients.
NEUROLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Carlo Trompetto, Lucio Marinelli, Laura Mori, Nicola Bragazzi, Giulia Maggi, Filippo Cotellessa, Luca Puce, Lucilla Vestito, Franco Molteni, Giulio Gasperini, Nico Farina, Luciano Bissolotti, Francesco Sciarrini, Marzia Millevolte, Fabrizio Balestrieri, Domenico Antonio Restivo, Carmelo Chisari, Andrea Santamato, Alessandra Del Felice, Paolo Manganotti, Carlo Serrati, Antonio Curra
Summary: By blocking neurotransmitters, BoNT-A can effectively treat muscle over-activity and pain in stroke patients. It has also been shown to increase p-ROM, which is mainly affected by muscle contracture. The study investigated the relationship between p-ROM and pain in post-stroke patients treated with BoNT-A.
Review
Health Care Sciences & Services
Luca Puce, Carlo Biz, Carlo Trompetto, Lucio Marinelli, Antonio Curra, Luca Cavaggioni, Matteo Formica, Vittorio Vecchi, Maria Chiara Cerchiaro, Khaled Trabelsi, Nicola Luigi Bragazzi, Pietro Ruggieri
Summary: Para-rowing is a rowing format that allows people with disabilities to participate, thanks to adapted equipment and rules. It made its debut at the 2008 Paralympic Games. Rigorous research is needed to support the pursuit of sporting excellence by para-rowers.
Article
Clinical Neurology
Andrea Tacchino, Rachele Di Giovanni, Erica Grange, Maria Marcella Spirito, Michela Ponzio, Mario Alberto Battaglia, Giampaolo Brichetto, Claudio Marcello Solaro
Summary: This study evaluates the equivalence between paper-and-pencil and electronic versions of patient-reported outcome (PRO) measures in people with multiple sclerosis (PwMS). The results suggest a high level of equivalence between the two versions, and show that PwMS prefer the electronic method.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Marcello Mario Mascia, Daniele Belvisi, Marcello Esposito, Roberta Pellicciari, Assunta Trinchillo, Carmen Terranova, Salvatore Bertino, Laura Avanzino, Francesca Di Biasio, Francesco Bono, Vincenzo Laterza, Christian Lettieri, Roberto Eleopra, Giovanni Fabbrini, Pierangelo Barbero, Laura Bertolasi, Maria Concetta Altavista, Roberto Erro, Roberto Ceravolo, Anna Castagna, Maurizio Zibetti, Anna Rita Bentivoglio, Giovanni Cossu, Luca Magistrelli, Cesa Scaglione, Alberto Albanese, Maria Sofia Cotelli, Salvatore Misceo, Antonio Pisani, Tommaso Schirinzi, Luca Maderna, Giovanna Squintani, Alfredo Berardelli, Giovanni Defazio
Summary: The study found that cerebrovascular risk factors may be associated with specific features of idiopathic adult onset dystonia, such as blepharospasm and sensory trick.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Psychology, Biological
Alessandro Botta, Mingqi Zhao, Jessica Samogin, Elisa Pelosin, Gaia Bonassi, Giovanna Lagravinese, Dante Mantini, Alessio Avenanti, Laura Avanzino
Summary: Using high-density electroencephalography (hd-EEG), this study found that the processing of fearful emotional body language (EBL) activates somatosensory areas early on and suppresses motor activity in healthy individuals. These findings provide high-temporal resolution evidence of the interplay between somatosensory and motor areas during the observation of EBL, shedding light on the sensorimotor mechanism supporting freezing behavior.
Article
Medicine, General & Internal
Jessica Podda, Andrea Tacchino, Anna Verri, Mario Alberto Battaglia, Giampaolo Brichetto, Michela Ponzio
Summary: The aim of this study was to develop and validate the Caregivers' Knowledge of Multiple Sclerosis (CareKoMS), a self-assessed questionnaire, to test MS knowledge in caregivers of people with MS. The results indicate that CareKoMS is a reliable self-assessed questionnaire that can be used in clinical practice and research.
Article
Clinical Neurology
Edoardo Monfrini, Laura Avanzino, Giovanni Palermo, Giulia Bonato, Gloria Brescia, Roberto Ceravolo, Giovanna Cantarella, Paola Mandich, Holger Prokisch, Karin Storm Vans Gravesande, Giulia Straccia, Antonio Elia, Chiara Reale, Celeste Panteghini, Giovanna Zorzi, Roberto Eleopra, Roberto Erro, Miryam Carecchio, Barbara Garavaglia, Michael Zech, Luigi Romito, Alessio Di Fonzo
Summary: This case collection expands the genetic and clinical spectrum of VPS16-related disease, prompting movement disorder specialists to suspect mutations of this gene not only in patients with isolated dystonia.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Health Care Sciences & Services
Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Placido Bramanti, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto
Summary: This paper describes the design, development, and usability testing of MS Fitness Intervention Training (MS-FIT), a Kinect-based tool implementing customized Pilates exercises for people with MS. The user-centered design approach was used to create an accessible and challenging tool for balance training. The usability testing showed that MS-FIT is a promising system for enhancing the motivation and engagement of people with MS in performing exercises.
JMIR SERIOUS GAMES
(2023)