期刊
EUROPEAN JOURNAL OF NEUROLOGY
卷 22, 期 2, 页码 253-260出版社
WILEY-BLACKWELL
DOI: 10.1111/ene.12467
关键词
apathy; behavioral disorders; cognitive dysfunctions; frontal dysfunctions; Parkinson's disease
资金
- Department of Psychology, Second University of Naples, Caserta, Italy
- IDC Hermitage Capodimonte
- University of Naples 'Parthenope', Italy
- Department of Neurological Sciences, University of Naples 'Federico II', Italy
- IDC Hermitage-Capodimonte
- University of Salerno, Italy
- Boehringer Ingelheim
- Novartis
- Schwarz Pharma/UCB
- Merck-Serono
- Solvay
- Lundbeck
Background and purposeApathy may be either a symptom of major depression or a behavioral disturbance occurring in concomitance with depression or alone in Parkinson's disease (PD). The aim of the present study was to determine the progression of cognitive impairment in drug-naive untreated PD patients with or without clinically significant apathy. MethodsSixty-two PD patients with a disease duration <2years and without history of present or past therapy with pro-dopaminergic agents were included and underwent the Apathy Evaluation Scale (S-AES), a clinical interview based on diagnostic criteria for apathy and a comprehensive neuropsychological battery to assess memory, frontal functions and visuospatial functions. Two years after the first assessment, all patients were re-evaluated on the S-AES, a clinical interview and neuropsychological tests. ResultsAccording to the cut-off value of the S-AES and diagnostic criteria for apathy, eight patients experienced apathy at both baseline and follow-up (A+A+), nine patients had apathy only at follow-up (A-A+), 37 patients never experienced apathy (A-A-) and eight patients showed apathy at the baseline only (A+A-). Cognitive performance significantly declined in all four groups. At both baseline and follow-up A+A+ performed worse than A-A- on visuospatial and frontal tests; A-A+ had lower scores than A-A- on the interference task of the Stroop test (IT-ST). Regression analysis showed that poor performance on the IT-ST at baseline was the only independent predictor of onset of apathy at follow-up. ConclusionsThe results indicated a relationship between apathy and dysexecutive syndrome in early PD. Reduced scores on the IT-ST may predict development of apathy in PD patients.
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