Review
Clinical Neurology
Massimo Filippi, Roberta Balestrino, Silvia Basaia, Federica Agosta
Summary: This article reviews studies applying neuroimaging to GBA-associated parkinsonism. The results show that GBA-PD patients exhibit a more aggressive disease progression in neuroimaging compared to iPD, with significant differences in cortical burden. Contrasting evidence is available regarding imaging and clinical findings in GBA-NMC, although subtle differences have been reported compared to healthy controls without mutations.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Miriam H. Terkelsen, Victor S. Hvingelby, Nicola Pavese
Summary: This review discusses the latest literature on GABAergic alterations in parkinsonian disorders, highlighting its role in motor symptoms, gait disturbances, cognition, and hallucinations. The review suggests potential research strategies for future neuroimaging studies on GABAergic changes in these disorders.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuting Li, Jianhua Feng, Teng Zhang, Kexin Shi, Yao Ding, Xiaohui Zhang, Chentao Jin, Jiayue Pan, Le Xue, Yi Liao, Xiawan Wang, Cheng Zhuo, Hong Zhang, Mei Tian
Summary: Atypical BECTS showed more widespread and severe hypo-metabolism than typical BECTS, and the combination of metabolic characteristics and clinical variables has the potential for clinical use in distinguishing between typical and atypical BECTS.
EUROPEAN RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nicolas Nicastro, Umberto Nencha, Pierre R. Burkhard, Valentina Garibotto
Summary: This study summarizes the current evidence on dopaminergic molecular imaging in the diagnostic evaluation of Parkinson's disease (PD), atypical parkinsonian syndromes, and dementia with Lewy bodies (DLB), as well as its potential to distinguish these conditions and estimate disease progression. Dopamine imaging has an outstanding potential for early detection of neurodegeneration.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Behavioral Sciences
Amina Nasri, Mouna Ben Djebara, Ikram Sghaier, Saloua Mrabet, Sabrina Zidi, Amina Gargouri, Imen Kacem, Riadh Gouider
Summary: This study explored the epidemiological features of atypical parkinsonian syndromes (APS) in a Tunisian population, showing a hospital prevalence of 20.6% with dementia with Lewy bodies (DLB) as the most common subtype. Age of onset proved to be a decisive factor for differential diagnosis, with males predominating in all subgroups except for multiple system atrophy (MSA).
BRAIN AND BEHAVIOR
(2021)
Review
Clinical Neurology
Sule Tinaz
Summary: Accurate and timely diagnosis of atypical parkinsonian syndromes (APS) remains a challenge. However, recent advances in MRI technology have introduced promising imaging modalities to aid in the diagnosis of APS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Biomedical
Ricardo Martins, Francisco Oliveira, Fradique Moreira, Ana Paula Moreira, Antero Abrunhosa, Cristina Januario, Miguel Castelo-Branco
Summary: This study explores the feasibility of developing a computer-aided diagnostic system for Parkinsonian syndromes using dynamic PET and MRI data. By combining structural and molecular imaging features, improvements were seen in binary classification of healthy/diseased status and comparable performance to DVR features in multiclass classifications.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Tian, Chuantao Zuo, A. Cahid Civelek, Ignasi Carrio, Yasuyoshi Watanabe, Keon Wook Kang, Koji Murakami, John O. Prior, Yan Zhong, Xiaofeng Dou, Congcong Yu, Chentao Jin, Rui Zhou, Fengtao Liu, Xinyi Li, Jiaying Lu, Hong Zhang, Jian Wang
Summary: This article introduces the international consensus and practice guideline, aiming to promote the standardized use of presynaptic dopaminergic PET imaging in parkinsonism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Piriyankan Ananthavarathan, B. Patel, S. Peeros, R. Obrocki, N. Malek
Summary: Non-motor symptoms (NMS) are common in both Parkinson's disease and atypical parkinsonian syndromes, including excessive daytime sleepiness, urinary dysfunction, and apathy. Recognizing and addressing these symptoms early is crucial for improving patients' quality of life.
JOURNAL OF NEUROLOGY
(2023)
Article
Neuroimaging
Anais El Ouartassi, Caroline Giordana, Aurelie Schiazza, David Chardin, Jacques Darcourt
Summary: This study aims to investigate the application patterns of [F-18]-FDOPA positron emission tomography imaging in corticobasal syndrome and compare them with patterns found in Parkinson's disease and progressive supranuclear palsy through visual and semi-quantitative analysis. It also aims to find correlations with clinical features and [F-18]-FDG positron emission tomography imaging. Retrospective study was conducted on 27 corticobasal syndrome patients who underwent [F-18]-FDOPA positron emission tomography imaging, comparing them with matched Parkinson's disease patients, progressive supranuclear palsy patients, and normal controls.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Medicine, General & Internal
Piotr Alster, Natalia Madetko, Bartosz Migda, Michal Nieciecki, Michal Kutylowski, Leszek Krolicki, Andrzej Friedman
Summary: Progressive supranuclear palsy syndrome (PSPS) and corticobasal syndrome (CBS) are clinical manifestations of tauopathic Parkinsonian syndromes. This study found significant asymmetry of perfusion of the amygdala in corticobasal syndrome, with more pronounced abnormalities observed in the left amygdala among patients with more severe Parkinsonian syndromes in CBS on the right. The comparison of the perfusion of tauopathic Parkinsonian syndromes should be extended by asymmetry analysis.
Article
Clinical Neurology
Fatma Zehra Calikusu, Sema Akkus, Esra Kochan Kizilkilic, Burc Cagri Poyraz, Ali Tarik Altunc, Gunes Kiziltan, Aysegul Gunduz
Summary: The study aimed to determine and describe the frequency and features of uncommon manifestations of atypical parkinsonian syndromes. The findings showed that atypical clinical features were present in different types of atypical parkinsonian syndromes with similar prevalence rates. These atypical features may include eyelid myoclonus, typical hummingbird sign on MRI, and ataxia, suggesting the possibility of genetic syndromes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Feng-Tao Liu, Xin-Yi Li, Jia-Ying Lu, Ping Wu, Ling Li, Xiao-Niu Liang, Zi-Zhao Ju, Fang-Yang Jiao, Ming-Jia Chen, Jing-Jie Ge, Yi-Min Sun, Jian-Jun Wu, Tzu-Chen Yen, Jian-Feng Luo, Chuantao Zuo, Jian Wang
Summary: This study systematically investigated the localization and magnitude of F-18-Florzolotau uptake in patients with the parkinsonian subtype of multiple system atrophy (MSA-P). The results showed elevated F-18-Florzolotau uptake in the putamen, globus pallidus, and dentate in MSA-P patients, which was not observed in patients with Parkinson's disease (PD). This increased signal was significantly associated with the core symptoms of MSA-P.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
G. Pin, J. Laboure, E. Guedj, O. Felician, S. Grimaldi, J. P. Azulay, M. Ceccaldi, L. Koric
Summary: This study investigated the metabolic brain correlates of ocular motor dysfunction in early Progressive Supranuclear Palsy (PSP) patients. The findings suggest the early involvement of Superior Colliculi (SC) in saccadic dysfunction, as decreased metabolism in SC correlates with decreased gain of vertical saccades, increased metabolism in SC and dorsal nuclei in the pons correlates with increased mean velocity of horizontal saccades, and decreased metabolism in posterior parietal region correlates with increased latency of horizontal saccades.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
T. Horowitz, S. Grimaldi, J. -P. Azulay, E. Guedj
Summary: Nuclear medicine techniques, such as PET and SPECT, play a significant role in the diagnosis of parkinsonism by providing biomarkers and distinguishing different types of parkinsonian syndromes.
REVUE NEUROLOGIQUE
(2022)
Article
Clinical Neurology
Alexander Rau, Nils Schroeter, Ganna Blazhenets, Andrea Dressing, Lea Walter, Elias Kellner, Tobias Bormann, Hansjorg Mast, Dirk Wagner, Horst Urbach, Cornelius Weiller, Philipp T. Meyer, Marco Reisert, Jonas A. Hosp
Summary: Using diffusion microstructure imaging, researchers found widespread interstitial oedema in subacute COVID-19 inpatients, which is associated with cognitive impairment and changes in brain metabolism.
Article
Neurosciences
Cornelius Weiller, Marco Reisert, Volkmar Glauche, Mariachristina Musso, Michel Rijntjes
Summary: Intelligible communication and covert conscious thought require the integration of external representations and inner abstract concepts. Through studying participants in the Human Connectome Project, researchers have identified two hub regions in the brain that connect different cognitive processes, facilitating recursion and forethought.
Article
Neurosciences
Nils Schroeter, Ganna Blazhenets, Lars Frings, Wolfgang H. Jost, Cornelius Weiller, Michel Rijntjes, Philipp T. Meyer, Joachim Brumberg
Summary: This study used [F-18]FDG PET to assess glucose metabolism in the substantia nigra (SN) of patients with Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP), and found that it can be used as a marker to distinguish neurodegenerative parkinsonian syndromes (NP) from controls. The method showed good diagnostic accuracy, especially for PD patients without the expression of a specific metabolic pattern.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Jonas A. Hosp, Andrea Dressing, Anika Engesser, Volkmar Glauche, Dorothee Kummerer, Ema B. Vaidelyte, Mariachristina Musso, Michel Rijntjes, Cornelius Weiller
Summary: This study explores the role of the dopaminergic ventral tegmental midbrain nuclei-motor cortex (VTMC) tract in post-stroke recovery. The study found that both the VTMC tract and the corticospinal tract (CST) degenerate after stroke, but only the degeneration of the VTMC tract is associated with lesion size. Regression analysis showed that changes in VTMC tract integrity are more strongly related to independence in daily activities, upper limb motor impairment, and cortical symptoms compared to CST, which is mainly associated with the degree of hemiparesis.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Mariacristina Musso, Eckart Altenmueller, Marco Reisert, Jonas Hosp, Ralf Schwarzwald, Bettina Blank, Julian Horn, Volkmar Glauche, Christoph Kaller, Cornelius Weiller, Martin Schumacher
Summary: Conducting is a well-structured system used to convey information about the rhythm and dynamic of a musical piece. Conductors communicate the musical tempo to the orchestra, creating a unified and expressive musical gestalt. This study found that conducting activates specific regions of the brain, including the supplementary and premotor cortex, superior temporal gyrus, and Broca's area, which are involved in sensorimotor mapping and language processing.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Editorial Material
Clinical Neurology
Cornelius Weiller, Michel Rijntjes
Article
Radiology, Nuclear Medicine & Medical Imaging
Tassilo Schiebler, Ivayla Apostolova, Franziska Lara Mathies, Catharina Lange, Susanne Klutmann, Ralph Buchert
Summary: This study evaluated the impact of attenuation and scatter correction on the visual interpretation and semi-quantitative analysis of dopamine transporter-SPECT in a large patient sample. The findings suggest that attenuation and scatter correction have minimal impact on the clinical utility of DAT-SPECT for the detection of nigrostriatal degeneration.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Anja Maeurer, Gudrun Himmel, Catharina Lange, Franziska Mathies, Ivayla Apostolova, Oliver Peters, Ralph Buchert
Summary: Individualized interpretation of detailed neuropsychological testing can differentiate between primary neurodegenerative and other etiologies of cognitive impairment in geriatric inpatients, including those with delirium in remission.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Nils Schroeter, Antonia Weiller, Michel Rijntjes, Andreas Harloff, Horst Urbach, Juraj Kukolja, Juergen Bardutzky, Cornelius Weiller, Lena-Alexandra Beume
Summary: Telemedicine plays an important role in emergency neurology, and head and/or gaze deviation can serve as a reliable biomarker for ischemic stroke and large vessel occlusions (LVOs), making it easier to assess.
JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivayla Apostolova, Tassilo Schiebler, Catharina Lange, Franziska Lara Mathies, Wencke Lehnert, Susanne Klutmann, Ralph Buchert
Summary: This study compared the effects of using a single I-123-FP-CIT template image and multiple templates representative of normal and different levels of Parkinson-typical reduction for stereotactical normalization of DAT-SPECT images. The results showed that using multiple templates for normalization could improve the separation between normal and abnormal putamen SBR, leading to better detection of nigrostriatal degeneration.
Article
Clinical Neurology
Nils Schroeter, Tobias Bormann, Michel Rijntjes, Ganna Blazhenets, Raissa Berti, Bastian E. A. Sajonz, Horst Urbach, Cornelius Weiller, Philipp T. Meyer, Alexander Rau, Lars Frings
Summary: This study suggests that microangiopathic white matter lesions do not have a significant impact on neurocognitive performance in Parkinson's disease, while neuronal dysfunction does.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Ralph Buchert, Florian Wegner, Hans-Juergen Huppertz, Georg Berding, Matthias Brendel, Ivayla Apostolova, Carsten Buhmann, Alexander Dierks, Sabrina Katzdobler, Martin Klietz, Johannes Levin, Nima Mahmoudi, Andreas Rinscheid, Sophia Rogozinski, Jost-Julian Rumpf, Christine Schneider, Sophia Stoecklein, Phoebe G. Spetsieris, David Eidelberg, Mike P. Wattjes, Osama Sabri, Henryk Barthel, Guenter Hoeglinger
Summary: This study evaluated FDG-PET in a sample of 41 PSP patients and found that automatic covariance pattern analysis outperformed visual interpretation in detecting PSP-RS and provided useful sensitivity for vPSP. Pattern expression analysis is clinically useful in suspected PSP to complement visual reading and voxel-based testing.
MOVEMENT DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roland Opfer, Julia Krueger, Lothar Spies, Ann-Christin Ostwaldt, Hagen H. Kitzler, Sven Schippling, Ralph Buchert
Summary: The study developed an automatic method for accurate and robust thalamus segmentation in T1w-MRI. A 3D convolutional neural network (3D-CNN) was trained using ground truth generated with FSL-FIRST. The results showed that the 3D-CNN method achieved accurate and stable thalamus segmentation.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Rau, Nils Schroeter, Michel Rijntjes, Fabian Bamberg, Wolfgang H. H. Jost, Maxim Zaitsev, Cornelius Weiller, Stephan Rau, Horst Urbach, Marco Reisert, Maximilian F. F. Russe
Summary: This study compared the performance of a Deep Neural Patchwork (DNP) with other established segmentation algorithms in accurately delineating atrophic structures in multiple system atrophy (MSA), Parkinson's disease (PD), and healthy controls. The results showed that DNP had significantly better performance in delineating the putamen compared to other algorithms, and it also demonstrated superior diagnostic accuracy in distinguishing MSA, PD, and healthy controls.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Kruger, Roland Opfer, Lothar Spies, Dennis Hedderich, Ralph Buchert
Summary: This study aimed to develop a deep convolutional neural network (CNN) for the detection of disease-specific brain atrophy without the need for a scanner-specific normal database. The CNN demonstrated similar performance to conventional methods and could potentially aid in the diagnosis of neurodegenerative diseases.
EUROPEAN RADIOLOGY
(2023)
