Review
Biotechnology & Applied Microbiology
Lauren S. Talman, Amie L. Hiller
Summary: Disturbances of gait are present in all stages of Huntington's disease, significantly impacting the quality of life for affected individuals. A cross-disciplinary approach to gait evaluation in HD using objective measures is highlighted in this scoping review.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Erica Menegatti, Simona Mandini, Anselmo Pagani, Beatrice Mandini, Valentina Zerbini, Tommaso Piva, Andrea Raisi, Marinella Fabbri, Marco Fogli, Gianni Mazzoni, Paolo Zamboni, Sergio Gianesini
Summary: This study investigates the effect of active stretching (AS) training on lower limb venous function and quality of life in patients with chronic venous insufficiency (CVI). The results show that AS training leads to a reduction in leg volume, an increase in ejection fraction rate, and improvements in postural outcomes. This suggests that an appropriate adapted physical exercise program could be beneficial in managing CVI patients.
Article
Neurosciences
Samuel Stuart, Alan Godfrey, Martina Mancini
Summary: The study found that the UpRight Go feedback device may improve neck/upper-back posture in PD during sitting and standing, but not during walking. Postural alignment response to the device may depend on attentional mechanisms.
Article
Health Care Sciences & Services
Allyson Flynn, Elisabeth Preston, Sarah Dennis, Colleen G. Canning, Natalie E. E. Allen
Summary: This study aimed to determine if physiotherapy supported by telehealth helped people with Parkinson disease (PwP) to adhere to a home-based exercise program and maintain their physical activity, and to understand their experiences of using telehealth during the COVID-19 pandemic. The results showed that telehealth physiotherapy enabled PwP to continue exercising at home and maintain their physical activity, and the flexibility of both the client and the service was crucial.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Engineering, Biomedical
Radhika Desai, Miguel Blacutt, Gregory Youdan, Nora E. Fritz, Lisa M. Muratori, Jeffrey M. Hausdorff, Monica Busse, Lori Quinn
Summary: This study evaluated postural control and gait in individuals with and without Huntington's disease using wearable sensors. Significant differences were found in postural control and gait measures between early and mid-disease stage, as well as non-Huntington's disease peers. Measures such as total sway, root mean square, and gait speed were important in classifying disease status. Root mean square during standing with feet apart significantly predicted clinical measure of chorea, while root mean square and total sway during standing with feet together significantly predicted clinical measure of tandem walking.
CLINICAL BIOMECHANICS
(2022)
Review
Behavioral Sciences
Carola Cosentino, Martina Putzolu, Susanna Mezzarobba, Margherita Cecchella, Tiziano Innocenti, Gaia Bonassi, Alessandro Botta, Giovanna Lagravinese, Laura Avanzino, Elisa Pelosin
Summary: The difficulty in assessing FOG and the variety of existing cues make it challenging to determine the most appropriate cueing modality and targets for personalized treatments for FOG. This systematic review aimed to determine the effectiveness of cues in reducing FOG and improving gait parameters, and whether medication state affects cue-related results.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Chemistry, Analytical
Yusuf Ozgur Cakmak, Can Olcek, Burak Ozsoy, Prashanna Khwaounjoo, Gunes Kiziltan, Hulya Apaydin, Aysegul Gunduz, Ozgur Oztop Cakmak, Sibel Ertan, Yasemin Gursoy-Ozdemir, Didem Gokcay
Summary: The study evaluates the potential use of a non-contact hand motion tracking system to extract GP information in Parkinson's Disease. The frequency of P/S contributes significantly to the prediction of GP, along with speed and acceleration. Additionally, there is a negative correlation between hand motion speed and BA score/combined UPDRS score.
Review
Psychology, Multidisciplinary
Taleb Fadaei Dehcheshmeh, Ali Shamsi Majelan, Behnaz Maleki
Summary: Despite its importance and significant impact on life, the relationship between posture and psyche has not been sufficiently studied and paid attention to. This review systematically summarizes the scientific framework of research on the relationship between depression and posture. The findings of the included studies suggest that people with depression tend to have a more slumped posture and spine abnormalities, especially in girls and high school ages.
CURRENT PSYCHOLOGY
(2023)
Review
Clinical Neurology
Ling Pan, Andrew Feigin
Summary: The article discusses new potential disease-modifying therapies for Huntington's disease that are currently being tested in human clinical trials and in preclinical development. These therapies include DNA/gene therapies, RNA modulation, and targeting abnormal downstream pathways, showing promise in addressing the complex pathogenesis of the disease.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Neurosciences
Tauana Callais Franco do Nascimento, Flavia Martins Gervasio, Antonia Pignolo, Guilherme Augusto Santos Bueno, Aline Araujo do Carmo, Darlan Martins Ribeiro, Marco D'Amelio, Felipe Augusto dos Santos Mendes
Summary: This study investigated the relationships between trunk posture, GPS, and gait spatiotemporal parameters in patients with PD. The results showed that trunk posture influenced GPS domains, mainly of the ankle and the knee, but was not related to spatiotemporal parameters during gait.
Article
Clinical Neurology
Gabriele Imbalzano, Domiziana Rinaldi, Giovanna Calandra-Buonaura, Manuela Contin, Federica Amato, Giulia Giannini, Luisa Sambati, Claudia Ledda, Alberto Romagnolo, Gabriella Olmo, Pietro Cortelli, Maurizio Zibetti, Leonardo Lopiano, Carlo Alberto Artusi
Summary: This study aimed to explore the challenges in treating FoG and other PD axial symptoms and analyze the effects of progressively increasing levodopa doses on the resistance of FoG, posture, speech, and altered gait features. The results showed that in a short-term evaluation, increasing LCIG dose can improve dopa-resistant FoG and gait issues in most advanced PD patients with good overall control of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Rehabilitation
Raima M. Amin, James J. Phillips, Andrew T. Humbert, Brenna A. Cholerton, Valerie D. Short, Melissa J. Smith, Cyrus P. Zabetian, Ignacio F. Mata, Valerie E. Kelly
Summary: This study aimed to determine the impact of baseline cognition on gait outcomes in Parkinson's disease patients after a treadmill training program. The results showed that patients with better baseline memory performance and milder disease severity had greater improvements in gait speed.
DISABILITY AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Georgios Krekoukias, Vasiliki Sakellari, Elisavet Anastasiadi, Georgios Gioftsos, Zacharias Dimitriadis, Konstantinos Soultanis, Ioannis D. Gelalis
Summary: The study aimed to evaluate kinetic and kinematic characteristics during gait analysis in patients with chronic low back pain before and after physiotherapy, including manual therapy techniques. The results showed that manual therapy treatment group demonstrated a tendency towards symmetry between the right and left side during gait.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Orthopedics
E. C. Bell, J. A. Wallis, A. J. Goff, K. M. Crossley, P. O'Halloran, C. J. Barton
Summary: This study investigated the effects of land-based exercise therapy on physical activity in people with knee osteoarthritis (KOA). The findings suggest that walking and mixed-exercise programs can improve physical activity in the short-term for KOA patients, while resistance-training alone does not have a significant impact. Combining resistance-training with education may increase physical activity in the medium-term, highlighting the importance of developing more effective long-term interventions for KOA patients.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Behavioral Sciences
Jacob W. Hinkel-Lipsker, Nicole M. Stoehr, Isaiah J. Lachica, Sean M. Rogers
Summary: The study investigated how physical fatigue affects young, healthy individuals' ability to navigate through obstacles, finding that fatigue leads to decreased toe clearance, increased heel clearance, and faster walking speed.
Article
Rehabilitation
Birgit Vahlberg, Birgitta Lindmark, Lena Zetterberg, Karin Hellstrom, Tommy Cederholm
DISABILITY AND REHABILITATION
(2017)
Article
Rehabilitation
Birgit Vahlberg, Tommy Cederholm, Birgitta Lindmark, Lena Zetterberg, Karin Hellstrom
DISABILITY AND REHABILITATION
(2017)
Article
Neurosciences
Marina Papoutsi, Nikolaus Weiskopf, Douglas Langbehn, Ralf Reilmann, Geraint Rees, Sarah J. Tabrizi
HUMAN BRAIN MAPPING
(2018)
Article
Clinical Neurology
Chris Frost, Amy Mulick, Rachael I. Scahill, Gail Owen, Elizabeth Aylward, Blair R. Leavitt, Alexandra Durr, Raymund A. C. Roos, Beth Borowsky, Julie C. Stout, Ralf Reilmann, Douglas R. Langbehn, Sarah J. Tabrizi, Cristina Sampaio
MOVEMENT DISORDERS
(2017)
Article
Clinical Neurology
Jeffrey D. Long, James A. Mills, Blair R. Leavitt, Alexandra Durr, Raymund A. Roos, Julie C. Stout, Ralf Reilmann, Bernhard Landwehrmeyer, Sarah Gregory, Rachael I. Scahill, Douglas R. Langbehn, Sarah J. Tabrizi
Article
Dentistry, Oral Surgery & Medicine
S. Rohrbach, F. Buettner, D. Pollex, P. Mathmann, L. Weinhold, R. Schubert, R. Reilmann
JOURNAL OF ORAL REHABILITATION
(2018)
Letter
Clinical Neurology
Ralf Reilmann, Robin Schubert, Stefan Bohlen, Christian Sass
MOVEMENT DISORDERS
(2018)
Letter
Clinical Neurology
Oliver W. J. Quarrell, Martha A. Nance, Peg Nopoulos, Ralf Reilmann, Mayke Oosterloo, Sarah J. Tabrizi, Hannah Furby, Carsten Saft, Raymund A. C. Roos, Ferdinando Squitieri, G. Bernhard Landwehrmeyer, Jean-Marc Burgunder
MOVEMENT DISORDERS
(2019)
Article
Clinical Neurology
Joaquin A. Vizcarra, Alvaro Sanchez-Ferro, Walter Maetzler, Luca Marsili, Lucia Zavala, Anthony E. Lang, Pablo Martinez-Martin, Tiago A. Mestre, Ralf Reilmann, Jeffrey M. Hausdorff, E. Ray Dorsey, Serene S. Paul, Judith W. Dexheimer, Benjamin D. Wissel, Rebecca L. M. Fuller, Paolo Bonato, Ai Huey Tan, Bastiaan R. Bloem, Catherine Kopil, Margaret Daeschler, Lauren Bataille, Galit Kleiner, Jesse M. Cedarbaum, Jochen Klucken, Aristide Merola, Christopher G. Goetz, Glenn T. Stebbins, Alberto J. Espay
MOVEMENT DISORDERS
(2019)
Article
Clinical Neurology
E. Schaeffer, S. Streich, I. Wurster, R. Schubert, R. Reilmann, S. Wolfram, D. Berg
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Multidisciplinary Sciences
Marine Lunven, Jennifer Hamet Bagnou, Katia Youssov, Alexis Gabadinho, Rafika Fliss, Justine Montillot, Etienne Audureau, Blanche Bapst, Graca Morgado, Ralf Reilmann, Robin Schubert, Monica Busse, David Craufurd, Renaud Massart, Anne Rosser, Anne-Catherine Bachoud-Levi
Summary: The digitized arithmetic task (DAT) is a fast, reliable, motor-free cognitive task applicable in several languages, able to unmask cognitive decline correlated with striatal atrophy in small cohorts of Huntington's disease patients. It is likely to be a useful endpoint in future trials for HD and other neurodegenerative diseases.
Article
Clinical Neurology
Christopher A. Ross, Ralf Reilmann, Francisco Cardoso, Elizabeth A. McCusker, Claudia M. Testa, Julie C. Stout, Blair R. Leavitt, Thong Pei, Bernhard Landwehrmeyer, Asuncion Martinez, Jamie Levey, Teresa Srajer, Jee Bang, Sarah J. Tabrizi
MOVEMENT DISORDERS CLINICAL PRACTICE
(2019)
Article
Clinical Neurology
Elisabeth Anens, Lena Zetterberg, Charlotte Urell, Margareta Emtner, Karin Hellstrom
Correction
Veterinary Sciences
Ann Essner, Lena Zetterberg, Karin Hellstrom, Pia Gustas, Hans Hogberg, Rita Sjostrom
ACTA VETERINARIA SCANDINAVICA
(2017)
Article
Gerontology
Susanna Tuvemo Johnson, Cathrin Martin, Elisabeth Anens, Ann-Christin Johansson, Karin Hellstrom
JOURNAL OF APPLIED GERONTOLOGY
(2018)