Letter
Clinical Neurology
Mayu Ishiguro, Hiroyo Yoshino, Yuanzhe Li, Aya Ikeda, Manabu Funayama, Kenya Nishioka, Nobutaka Hattori
Summary: Compound heterozygosity of ATP10B is considered a risk factor for young-onset Parkinson's disease, but genetic screening in this study found little evidence of pathogenicity for the identified gene variants in patients with young-onset sporadic PD and autosomal recessive PD.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Geriatrics & Gerontology
Yi Guo, Yan Sun, Zhi Song, Wen Zheng, Wei Xiong, Yan Yang, Lamei Yuan, Hao Deng
Summary: The study did not find significant roles of SNCA gene variants in the development of Parkinson's disease in the Han Chinese population. Literature review indicates that patients with SNCA duplication or triplication are more likely to exhibit psychiatric signs and cognitive decline/dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Alfonsina Tirozzi, Nicola Modugno, Nicole Piera Palomba, Rosangela Ferese, Alessia Lombardi, Enrica Olivola, Alessandro Gialluisi, Teresa Esposito
Summary: The study found that late PD onset and male gender have a protective effect against LID risk, with disease duration being the most prominent feature influencing LID risk. Therefore, personalized therapeutic protocols are important for PD patients in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Bernabe Bustos, Kimberley Billingsley, Cornelis Blauwendraat, J. Raphael Gibbs, Ziv Gan-Or, Dimitri Krainc, Andrew B. Singleton, Steven J. Lubbe
Summary: Bustos et al. conducted the first genome-wide meta-analysis of common short tandem repeats (STRs) in Parkinson's disease and identified four new independent risk factors. They found that STRs contribute to the heritability of Parkinson's disease and that STR-associated genes are enriched in Parkinson's disease-relevant tissues and pathways.
Article
Clinical Neurology
Lola Cook, Jeanine Schulze, Jennifer Verbrugge, James C. Beck, Karen S. Marder, Rachel Saunders-Pullman, Christine Klein, Anna Naito, Roy N. Alcalay
Summary: This study evaluated the types of clinical genetic testing offered for Parkinson's disease (PD) and found 502 unique clinical genetic tests, including 11 diagnostic PD panels. The differences in panel sizes were mainly due to the inclusion of genes linked to atypical parkinsonism and dystonia disorders. Expert opinion is urgently needed to determine the genes to be included in a commercial multi-gene panel for PD.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Alessio Di Fonzo, Marco Percetti, Edoardo Monfrini, Ilaria Palmieri, Alberto Albanese, Micol Avenali, Anna Bartoletti-Stella, Fabio Blandini, Gloria Brescia, Giovanna Calandra-Buonaura, Rosa Campopiano, Sabina Capellari, Isabel Colangelo, Giacomo Pietro Comi, Giada Cuconato, Rosangela Ferese, Caterina Galandra, Stefano Gambardella, Barbara Garavaglia, Andrea Gaudio, Emiliano Giardina, Federica Invernizzi, Paola Mandich, Rossana Mineri, Celeste Panteghini, Chiara Reale, Lucia Trevisan, Stefania Zampatti, Pietro Cortelli, Enza Maria Valente
Summary: This study attempts to harmonize the reporting of PD genetic testing across multiple diagnostic labs and highlights the current challenges in interpreting genetic variants from NGS-multigene panels, which has significant implications for counseling.
MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Yige Wang, Yuwen Zhao, Hongxu Pan, Qian Zeng, Xiaoxia Zhou, Yaqin Xiang, Zhou Zhou, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jifeng Guo, Beisha Tang, Qiao Yu, Zhenhua Liu
Summary: This study comprehensively investigated the association between rare variants in dystonia-related genes and Parkinson's disease (PD) in a large Chinese cohort. The results suggested that variants in several dystonia-related genes, particularly COL6A3 and TH, are potentially associated with PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Gabriel Torrealba-Acosta, Eric Yu, Tanya Lobo-Prada, Javier Ruiz-Martinez, Ana Gorostidi-Pagola, Ziv Gan-Or, Kenneth Carazo-Cespedes, Jean-Francois Trempe, Ignacio F. Mata, Jaime Fornaguera-Trias
Summary: Most research on PD has focused on European populations, resulting in underrepresentation of Latin American populations. This study characterized PD patients of Costa Rican origin and sequenced genes associated with familial PD and atypical parkinsonism. Physical activity correlated with better motor performance, while increased education was associated with better cognitive function. No association was found between tested genes and PD, but rare variants in LRRK2 and non-synonymous GBA variants were identified.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Thomas Gasser
Summary: The identification of disease-causing mutations or strong risk factors for Parkinson's disease in specific genes has led to a better understanding of disease pathogenesis. Many gene and mutation-specific targeted disease-modifying treatments are being developed and studied. Therefore, it is important to raise awareness and offer genetic testing to patients considering innovative trials.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Clinical Neurology
Gian Pal, Lola Cook, Jeanine Schulze, Jennifer Verbrugge, Roy N. Alcalay, Marcelo Merello, Carolyn M. Sue, Soraya Bardien, Vincenzo Bonifati, Sun Ju Chung, Tatiana Foroud, Emilia Gatto, Anne Hall, Nobutaka Hattori, Tim Lynch, Karen Marder, Deborah Mascalzoni, Ivana Novakovic, Avner Thaler, Deborah Raymond, Mehri Salari, Ali Shalash, Oksana Suchowersky, Niccolo E. Mencacci, Tanya Simuni, Rachel Saunders-Pullman, Christine Klein
Summary: Testing for genetic markers in Parkinson's disease is increasingly common, and although there are no proven gene-targeted therapies, clinical trials are underway. However, there is a lack of consensus and guidelines in genetic testing practices, and various gaps and controversies need to be addressed, including appropriateness of testing, variation based on ethnicity, long-term outcomes, and resource needs.
MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Karim E. Shalaby, Omar M. A. El-Agnaf
Summary: Gene therapy has the potential to replace current treatments for Parkinson's disease and has been shown to be safe and effective in current trials.
Article
Neurosciences
Yong-Ping Chen, Xiao-Jing Gu, Ru-Wei Ou, Ling-Yu Zhang, Yan-Bing Hou, Kun-Cheng Liu, Bei Cao, Qian-Qian Wei, Wei Song, Bi Zhao, Ying Wu, Jing-Qiu Cheng, Hui-Fang Shang
Summary: Recent genetic studies have identified rare and likely pathogenic variants in the PSAP gene, particularly in the SapC domain, showing a role in idiopathic Parkinson's disease in the Chinese population. An intronic variant potentially linked to reduced risk for PD was also found. Patients carrying these pathogenic variants typically exhibit typical PD motor symptoms, respond well to levodopa treatment, and show slow disease progression without cognitive impairment.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lai Kuan Lee, Nur Anis Raihana Mhd Rodzi
Summary: This review reports the discovery of coffee-gene interaction for the protective management of Parkinson's Disease (PD), and outlines the mechanisms by which coffee regulates gene expressions and influences the pathogenesis of PD. Furthermore, the neuroprotective mechanisms of coffee for the amelioration of PD are elucidated.
Article
Clinical Neurology
Na Song, Yan Wang, Liangxing Zhou, Junli Zhang, Fan Wu, Mengpeng Li, Wei Wang, Yanming Liu, Xianjie Lu, Qingfa Chen, Nan Zhang, Yongjian Yan, Fabin Han
Summary: This study sequenced the LRP10 gene in 129 Chinese patients with PD and identified four potentially pathogenic mutations, providing further evidence for the association between LRP10 and PD in Chinese patients.
NEUROLOGICAL SCIENCES
(2023)
Review
Immunology
Alexi Nott, Inge R. Holtman
Summary: Microglia, as the macrophages in the brain, play a vital role in brain homeostasis and are implicated in various brain disorders. Neuroinflammation has emerged as a potential therapeutic target for neurodegeneration, but the specific function of microglia in different neurodegenerative disorders is still being actively studied.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
You Ni, Dingding Shen, Ying Zhang, Yaying Song, Yining Gao, Qinming Zhou, Lu He, Dou Yin, Ying Wang, Fan Song, Meiyuan Chen, Yajun Lian, Yuan Chen, Xing Zhao, Xiang Zhang, Xiangjun Chen, Yuting Wang, Ling Zhang, Nanxun Mo, Dong Lv, Jun Liu, Zhifeng Mao, Lisheng Peng, Sheng Chen
Summary: The clinical spectrum of anti-IgLON5 disease is diverse, with symptoms including sleep disturbances, cognitive impairment, and movement disorders. Some patients may have parainfectious causes, and coexisting neural autoantibodies or other autoimmune diseases were identified in some cases. Most patients showed improvement with immunotherapy, and overall clinical outcomes were favorable for the majority of patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
You Ni, Zhao Yang, Qinming Zhou, Jun Liu, Haiyan Zhou, Sheng Chen
Summary: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with diverse clinical manifestations and difficulties in diagnosis. Chinese NIID patients have clinical features including an average onset age of 60.18 years, average duration of 4.06 years, and tremor as the most common initial symptom. MRI findings show high-intensity U-fibers signals, focal leukoencephalopathy, and cortical swelling. Reversible asymmetric leukoencephalopathy can also indicate the disease.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Xiaojiao Xu, Jingjing Zhang, Song Li, Murad Al-Nusaif, Qinming Zhou, Sheng Chen, Weidong Le
Summary: The study found that neuroinflammation in the early pathogenesis of ALS is associated with increased immune-related genes, and BST2 may serve as a potential target for ameliorating microglia-mediated neuroinflammation pathologies in ALS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Immunology
Qinming Zhou, Tianxiao Zhang, Huanyu Meng, Dingding Shen, Yao Li, Lu He, Yining Gao, Yizongheng Zhang, Xinyun Huang, Hongping Meng, Biao Li, Min Zhang, Sheng Chen
Summary: This study found that there are changes in cerebral blood flow (CBF) in different brain regions of multiple sclerosis (MS) patients, and these changes are related to disease severity. Compared to healthy individuals, the average CBF in MS patients is higher, and patients with significantly increased CBF have worse disease severity. Additionally, there is a strong association between CBF and disease scores and serum biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Yizongheng Zhang, Qinming Zhou, Lisheng Peng, Sheng Chen
ANNALS OF NEUROLOGY
(2023)
Review
Cell Biology
Yi-Zong Heng Zhang, You Ni, Yi-Ning Gao, Ding-Ding Shen, Lu He, Dou Yin, Huan-Yu Meng, Qin-Ming Zhou, Ji Hu, Sheng Chen
Summary: Anti-IgLON5 disease is a complex autoimmune disorder of the nervous system associated with autoantibodies against IgLON5. It has characteristics of both autoimmunity and neurodegeneration, and the neuronal damage induced by IgLON5 antibody is irreversible. The disease is difficult to diagnose and treat, and further research is needed to better understand it.
NEURAL REGENERATION RESEARCH
(2023)
Article
Immunology
Qinming Zhou, Dou Yin, Jianfang Ma, Sheng Chen
Summary: This study presents three cases of autoimmune encephalitis (AE) treated with ofatumumab (OFA), an anti-CD20 antibody. OFA was administered subcutaneously at a dose of 20 mg two or three times within three weeks. The patients had mild adverse effects but showed favorable responses with reduced antibody titer and clinical symptom improvement. During a three-month follow-up, their symptoms remained stable or even improved. OFA injection is demonstrated to be a safe and effective therapeutic option for treating AE.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Letter
Clinical Neurology
Dingding Shen, Qinming Zhou, Huanyu Meng, Min Zhang, Lisheng Peng, Sheng Chen
JOURNAL OF NEUROLOGY
(2023)
Review
Cell Biology
Xinyue Deng, Lamei Yuan, Joseph Jankovic, Hao Deng
Summary: PLA2G6-associated neurodegeneration (PLAN) is a continuum of clinically and genetically heterogeneous neurodegenerative disorders with overlapping features. It is caused by variants in the PLA2G6 gene, which encodes an enzyme involved in membrane homeostasis, signal transduction, mitochondrial dysfunction, and α-synuclein aggregation. This review discusses the structure and function of the PLA2G6 gene, various PLAN disease phenotypes, and future research strategies.
AGEING RESEARCH REVIEWS
(2023)
Review
Genetics & Heredity
Lamei Yuan, Ruikang Yang, Hao Deng
Summary: Auricular fistula is a common congenital malformation characterized by a small opening in the skin and a subcutaneous cyst. It can vary in classification based on the position and direction of the fistula. The etiopathogenesis is believed to be an incorrect fusion of six auricular hillocks. This article provides a comprehensive review of auricular fistula, focusing on the congenital preauricular fistula, including its clinical manifestations, embryological development, genetics, examinations, treatments, and associated syndromes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Clinical Neurology
Sijia Du, Cheng Yuan, Qinming Zhou, Xinyun Huang, Hongping Meng, Meidi Chen, Hanzhong Wang, Qiu Huang, Suncheng Xiang, Dahong Qian, Biao Li, Sheng Chen, Min Zhang
Summary: In this study, a deep learning-based method was developed to extract radiomics features from PET and MR images for prediction of ARR in MS patients. The results showed that the deep learning and PET/MR radiomics-based model is an effective tool in assisting ARR classification of MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Yining Gao, Hongxia Li, Huoqing Luo, You Ni, Yifan Feng, Lu He, Qinming Zhou, Ji Hu, Sheng Chen
Summary: This study investigated the underlying mechanisms of movement disorders caused by anti-IgLON5 antibodies. The results showed that mice injected with these antibodies exhibited persistent movement impairments for up to 3 months, which may be related to impaired dopaminergic pathway and neurodegenerative changes induced by the antibodies.
Article
Health Care Sciences & Services
Zhiguo Li, Chao Zhang, Ting Chang, Xinghu Zhang, Huan Yang, Feng Gao, Jinzhou Feng, Hongbo Liu, Sheng Chen, Lihua Wang, Chunsheng Yang, Huining Li, Yuesong Pan, Jacqueline Palace, Fu-Dong Shi
Summary: This prospective multicenter cohort study evaluated the diagnostic accuracy of cell-based assay (CBA), radioimmunoprecipitation assay (RIPA), and enzyme-linked immunosorbent assay (ELISA) in detecting AChR and MuSK autoantibodies for the diagnosis of myasthenia gravis (MG).
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Immunology
Ruinan Shen, Dingding Shen, Qinming Zhou, Min Zhang, Sheng Chen
Summary: The SARS-CoV-2 vaccine is considered the most effective method to prevent infection, but in very rare cases, autoimmune neurological diseases may occur. This article reports three rare cases of autoimmune encephalitis with definite auto-antibody after SARS-CoV-2 vaccination, all of whom had good prognosis after treatment. 18F-DPA-714 PET/MRI may be a powerful tool for quantitative analysis of neuroinflammation in patients of autoimmune encephalitis.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Article
Neurosciences
Huanyu Meng, Shuyu Zheng, Shaicun Yuan, Qinming Zhou, Yining Gao, You Ni, Lu He, Dou Yin, Min Zhang, Sheng Chen
Summary: This study reports a method using F-18-florbetapir positron emission tomography-magnetic resonance imaging (PET/MRI) to evaluate myelin recovery in GFAP-A patients. The study found that after treatment, there was a significant increase in F-18-florbetapir uptake in the brain lesions of the patient, along with a reduced disability score.
TRANSLATIONAL NEUROSCIENCE
(2022)