Article
Clinical Neurology
Jia Zhou, Rui He, Xiaoyu Xu, Xiaoer Wei, Minghua Li, Feng Wang, Yuehua Li
Summary: Diffusion kurtosis imaging (DKI) has an added diagnostic value in patients with transient ischemic attack (TIA) by detecting abnormalities in patients with normal diffusion-weighted imaging (DWI) findings that are consistent with clinical symptoms. The presence of abnormality on baseline DKI is associated with a higher risk of recurrent stroke, and the location of the DKI abnormality corresponds to the development of new ischemic lesions in recurrent stroke patients with TIA.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Azael C. Novo, Pedro A. Pinzon-Benavides, Pablo Rozas-Fernandez, Mar Martinez-Palicio, Aida Garcia-Rua, Celia Anton-Gonzalez, Ignacio Casado-Menendez, Roberto Suarez-Moro, M. Teresa Temprano-Fernandez
Summary: Early use of MRI in suspected TIA patients helps gather evidence of CRIS and optimizes diagnostic and therapeutic approaches. Differentiated therapeutic management should be provided for TIA and CRIS patients.
REVISTA DE NEUROLOGIA
(2022)
Article
Peripheral Vascular Disease
Pan Chen, Qiong Wu, Xuewei Xie, Jing Jing, Hongqiu Gu, Xianwei Wang, Xia Meng, Liping Liu, Yilong Wang, Yongjun Wang
Summary: Little is known about the relationship between baseline systolic blood pressure (SBP) and subsequent clinical events in patients with different lesion patterns on diffusion weighted imaging (DWI). However, this study found that patients with non-lacunar infarction had the highest risk of recurrent stroke, and high baseline SBP was significantly associated with increased risk of short- and long-term recurrent strokes in these patients.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Clinical Neurology
Aoibhin Clarke, Catriona Reddin, Robert Murphy, Martin J. O'Donnell
Summary: The study aimed to determine whether prior use of antiplatelet therapy affects the effectiveness of dual antiplatelet therapy in patients with acute minor ischaemic stroke or transient ischaemic attack. The results showed that there was no significant difference in the effectiveness of dual antiplatelet therapy between patients with and without prior aspirin therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Raed A. Joundi, Amy Y. X. Yu, Eric E. Smith, Charlotte Zerna, Andrew M. Penn, Robert F. Balshaw, Kristine Votova, Maximilian B. Bibok, Melanie Penn, Viera Saly, Janka Hegedus, Shelagh B. Coutts
Summary: The relationship between the duration of transient neurological events and the presence of diffusion-weighted lesions varies depending on symptom type. For focal-only symptoms, there is a continuous increase in the probability of DWI lesion with longer duration, particularly in women. However, for nonfocal or mixed symptoms, the probability of DWI lesion remains constant regardless of duration.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Yuji Shiga, Shiro Aoki, Naohisa Hosomi, Ryota Nomura, Masahiro Nakamori, Tomohisa Nezu, Keisuke Tachiyama, Teppei Kamimura, Naoto Kinoshita, Ryo Shimomura, Yuki Hayashi, Hayato Matsushima, Eiji Imamura, Hiroki Ueno, Shinichi Wakabayashi, Kazuhiko Nakano, Tatsuo Kohriyama, Hirofumi Maruyama
Summary: This study identified an association between the presence of cnm-positive S. mutans and DWI hyperintensities in patients with acute ICH.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marta Olive-Gadea, David Cano, Marc Rodrigo-Gisbert, Marian Muchada, Estefania Montiel, Maria Baladas, Ester Sanchez-Gavilan, Carolina Paredes, Alvaro Garcia-Tornel, Marta Rubiera, Manuel Requena, Marc Ribo, Carlos A. Molina
Summary: Patient-reported outcome measures (PROMs) provide valuable information for assessing the long-term outcomes of stroke patients. This study used a mobile app to evaluate PROMs in patients with minor stroke or transient ischemic attack and found a correlation between patient-reported outcomes and clinician-assessed outcomes, although some differences were observed.
Editorial Material
Geriatrics & Gerontology
Ekow A. Mensah, Jane A. H. Masoli, Chakravarthi Rajkumar
Summary: With the ageing population increasing, the burden of cardiovascular disease is rising. Age and Ageing have compiled collections of their key cardiovascular themed papers, focusing on blood pressure, coronary heart disease, and heart failure. This commentary summarizes studies published in Age and Ageing that highlight the importance of a multidisciplinary, person-centered approach to care, conscientious identification and management of risk factors, and prevention strategies to ultimately reduce the burden of stroke care on healthcare financing.
Article
Cardiac & Cardiovascular Systems
Christian Boehme, Lena Domig, Silvia Komarek, Thomas Toell, Lukas Mayer, Benjamin Dejakum, Stefan Krebs, Raimund Pechlaner, Alexandra Bernegger, Christoph Mueller, Gerhard Rumpold, Andrea Griesmacher, Marion Vigl, Gudrun Schoenherr, Christoph Schmidauer, Julia Ferrari, Wilfried Lang, Michael Knoflach, Stefan Kiechl
Summary: This study aims to conduct a long-term follow-up of patients with ischaemic stroke or transient ischaemic attack to investigate whether the STROKE-CARD care program can prevent recurrent cardiovascular events and improve quality of life in the long run.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Medicine, General & Internal
Ke-Hang Xie, Ling-Ling Liu, Yun-Ru Liang, Chu-Yin Su, Hua Li, Run-Ni Liu, Qing-Qing Chen, Jia-Sheng He, Yong-Kun Ruan, Wang-Kai He
Summary: The study found that red blood cell distribution width (RDW) can predict subsequent stroke in patients with transient ischaemic attack (TIA). The RDW values of patients with ischaemic stroke (IS) and haemorrhagic stroke (HS) after TIA were significantly higher than patients with TIA. RDW was independently associated with stroke, especially ischaemic stroke, after TIA.
ANNALS OF MEDICINE
(2022)
Article
Neurosciences
Qingqing Xu, Yan Zhu, Xi Zhang, Dan Kong, Shaofeng Duan, Lili Guo, Xindao Yin, Liang Jiang, Zaiyi Liu, Wanqun Yang
Summary: This study aimed to explore whether radiomics features extracted from DWI and FLAIR images can predict the clinical outcome of patients with acute ischaemic stroke. A radiomics nomogram combining patient characteristics was built and evaluated in test and validation sets. Ultimately, decision curve analysis confirmed the clinical value of this nomogram in predicting stroke prognosis.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Kailash Krishnan, Zhe Kang Law, Jatinder S. Minhas, Philip M. Bath, Thompson G. Robinson, Nikola Sprigg, Akash Mavilakandy, Timothy J. England, David Eveson, Amit Mistri, Jesse Dawson, Jason P. Appleton
Summary: Acute stroke is a leading cause of disability and mortality, necessitating urgent evaluation and treatment. This review examines four antiplatelet treatments for non-cardioembolic stroke prevention and highlights gaps in the evidence for potential future trials.
Article
Clinical Neurology
Jiahuan Guo, Jiaokun Jia, Jia Zhang, Xinmin Liu, Guangshuo Li, Xingquan Zhao, Yanfang Liu
Summary: The stress hyperglycaemia ratio (SHR) is associated with the severity and adverse outcomes of ischaemic stroke in young adults. Higher SHR values are linked to more severe stroke and poor functional outcomes at 90-day follow-up, especially in non-diabetic patients. This study suggests that SHR may be an important marker for assessing the prognosis of ischaemic stroke in young adults.
CEREBROVASCULAR DISEASES
(2023)
Article
Multidisciplinary Sciences
Jong-Ho Park, Sun U. Kwon, Hyuk Sung Kwon, Sung Hyuk Heo
Summary: Prior ICH is associated with WMH severity, increasing the risk of both ischemic and hemorrhagic stroke. In patients with ICH, advanced WMH is linked to higher risk of ischemic stroke, while mild WMH is associated with increased risk of hemorrhagic stroke.
SCIENTIFIC REPORTS
(2021)
Article
Rehabilitation
Jenni Andersson, Britt-Marie Stalnacke, Ann Sorlin, Gustaf Magaard, Xiaolei Hu
Summary: The study found that most disabilities after transient ischaemic attack involved emotion, strength, and participation domains, with women and elderly subjects reporting more disabilities. Activities of daily living/instrumental activities of daily living, participation, and overall recovery showed significant, although low-to-moderate, associations with other SIS domains.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Clinical Neurology
Fine Dietrich, Alexandros A. Polymeris, Melina Verbeek, Stefan T. Engelter, Kurt E. Hersberger, Sabine Schaedelin, Isabelle Arnet, Philippe A. Lyrer
Summary: The study suggests that a major disruption of social life (i.e., the imposed COVID-19 lockdown) is unlikely to significantly affect the medication intake behavior of patients with high pre-established adherence, but might have an impact on patients with previously suboptimal adherence.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Giulio Bicciato, Markus Arnold, Aidan Gebhardt, Mira Katan
Summary: The purpose of this review is to discuss the potential clinical implementation of promising blood biomarkers in order to achieve a more individualized treatment allocation and lower recurrence rates of ischemic stroke. Recent findings suggest that blood-based biomarkers have the potential to improve the identification of underlying causes as well as risk stratification of patients, leading to a refinement of decision algorithms for treatment allocation in secondary ischemic stroke prevention.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jeanne du Fay de Lavallaz, Alexandra Prepoudis, Maria Janina Wendebourg, Eva Kesenheimer, Diego Kyburz, Thomas Daikeler, Philip Haaf, Julia Wanschitz, Wolfgang N. Loescher, Bettina Schreiner, Mira Katan, Hans H. Jung, Britta Maurer, Angelika Hammerer-Lercher, Agnes Mayr, Danielle M. Gualandro, Annemarie Acket, Christian Puelacher, Jasper Boeddinghaus, Thomas Nestelberger, Pedro Lopez-Ayala, Noemi Glarner, Samyut Shrestha, Robert Manka, Joanna Gawinecka, Salvatore Piscuoglio, John Gallon, Sophia Wiedemann, Michael Sinnreich, Christian Mueller
Summary: This study aimed to confirm the cardiac specificity of cTnT in patients with various skeletal muscle disorders (SMDs). The results showed that elevations in cTnT concentrations in patients with active chronic SMDs are common and not attributable to cardiac disease, while this phenomenon was not observed for cTnI. The re-expression of cTnT in skeletal muscle may partially explain this.
Article
Clinical Neurology
Benjamin Wagner, Johannes Lorscheider, Andrea Wiencierz, Kristine Blackham, Marios Psychogios, Daniel Bolliger, Gian Marco De Marchis, Stefan T. Engelter, Philippe Lyrer, Patrick R. Wright, Urs Fischer, Pasquale Mordasini, Stefania Nannoni, Francesco Puccinelli, Timo Kahles, Giovanni Bianco, Emmanuel Carrera, Andreas R. Luft, Carlo W. Cereda, Georg Kagi, Johannes Weber, Krassen Nedeltchev, Patrik Michel, Jan Gralla, Marcel Arnold, Leo H. Bonati
Summary: This large study found that patients with anterior circulation stroke treated with general anesthesia during endovascular treatment had worse functional outcomes compared to those treated without general anesthesia. This finding appears to be independent of patient characteristic differences between the groups.
Article
Clinical Neurology
Maurizio Paciaroni, Valeria Caso, Giancarlo Agnelli, Maria Giulia Mosconi, Michela Giustozzi, David Julian Seiffge, Stefan T. Engelter, Philippe Lyrer, Alexandros A. Polymeris, Lilian Kriemler, Annaelle Zietz, Jukka Putaala, Daniel Strbian, Liisa Tomppo, Patrik Michel, Davide Strambo, Alexander Salerno, Suzette Remillard, Manuela Buehrer, Odessa Bavaud, Peter Vanacker, Susanna Zuurbier, Laetitia Yperzeele, Caroline M. J. Loos, Manuel Cappellari, Andrea Emiliani, Marialuisa Zedde, Azmil Abdul-Rahim, Jesse Dawson, Robert Cronshaw, Erika Schirinzi, Massimo Del Sette, Christoph Stretz, Narendra Kala, Michael Reznik, Ashley Schomer, Brian Mac Grory, Mahesh Jayaraman, Ryan McTaggart, Shadi Yaghi, Karen L. Furie, Luca Masotti, Elisa Grifoni, Danilo Toni, Angela Risitano, Anne Falcou, Luca Petraglia, Enrico Maria Lotti, Marina Padroni, Lucia Pavolucci, Piergiorgio Lochner, Giorgio Silvestrelli, Alfonso Ciccone, Andrea Alberti, Michele Venti, Laura Traballi, Chiara Urbini, Odysseas Kargiotis, Alessandro Rocco, Marina Diomedi, Simona Marcheselli, Pietro Caliandro, Aurelia Zauli, Giuseppe Reale, Kateryna Antonenko, Eugenia Rota, Tiziana Tassinari, Valentina Saia, Francesco Palmerini, Paolo Aridon, Valentina Arnao, Serena Monaco, Salvatore Cottone, Antonio Baldi, Cataldo D'Amore, Walter Ageno, Samuela Pegoraro, George Ntaios, Dimitrios Sagris, Sotirios Giannopoulos, Maria Kosmidou, Evangelos Ntais, Michele Romoli, Leonardo Pantoni, Silvia Rosa, Pierluigi Bertora, Alberto Chiti, Isabella Canavero, Carlo Emanuele Saggese, Maurizio Plocco, Elisa Giorli, Lina Palaiodimou, Eleni Bakola, Georgios Tsivgoulis, Fabio Bandini, Antonio Gasparro, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Raffaele Ornello, Simona Sacco, Nemanja Popovic, Umberto Scoditti, Antonio Genovese, Licia Denti, Yuriy Flomin, Michelangelo Mancuso, Elena Ferrari, Maria Chiara Caselli, Leonardo Ulivi, Nicola Giannini, Gian Marco De Marchis
Summary: Patients with atrial fibrillation who suffer a stroke despite being on nonvitamin K antagonist oral anticoagulant therapy face a high risk of recurrent ischemic stroke and bleeding. Further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischemic stroke and bleeding.
Article
Clinical Neurology
Martina B. Goeldlin, Achim Mueller, Bernhard M. Siepen, Madlaine Mueller, Davide Strambo, Patrik Michel, Michael Schaerer, Carlo W. Cereda, Giovanni Bianco, Florian Lindheimer, Christian Berger, Friedrich Medlin, Roland Backhaus, Nils Peters, Susanne Renaud, Loraine Fisch, Julien Niederhaeuser, Emmanuel Carrera, Elisabeth Dirren, Christophe Bonvin, Rolf Sturzenegger, Timo Kahles, Krassen Nedeltchev, Georg Kaegi, Jochen Vehoff, Biljana Rodic, Manuel Bolognese, Ludwig Schelosky, Stephan Salmen, Marie-Luise Mono, Alexandros A. Polymeris, Stefan T. Engelter, Philippe Lyrer, Susanne Wegener, Andreas R. Luft, Werner Z'Graggen, David Bervini, Bastian Volbers, Tomas Dobrocky, Johannes Kaesmacher, Pasquale Mordasini, Thomas R. Meinel, Marcel Arnold, Javier Fandino, Leo H. Bonati, Urs Fischer, David J. Seiffge
Summary: Knowledge about different etiologies of non-traumatic intracerebral hemorrhage (ICH) and their outcomes is scarce. Hypertension is the leading etiology of ICH, but other etiologies are also common. Around one-third of patients achieve functional independence at 3 months, but the mortality rate is high. The risk of ischemic stroke within 3 months of ICH is higher than the risk of recurrent hemorrhage, except for patients with cerebral amyloid angiopathy (CAA).
Article
Clinical Neurology
Alexandros A. Polymeris, Annaelle Zietz, Fabian Schaub, Louisa Meya, Christopher Traenka, Sebastian Thilemann, Benjamin Wagner, Lisa Hert, Valerian L. Altersberger, David J. Seiffge, Flurina Lyrer, Tolga Dittrich, Ines Piot, Josefin Kaufmann, Lea Barone, Ludvig Dahlheim, Sophie Flammer, Nikolaos S. Avramiotis, Nils Peters, Gian Marco De Marchis, Leo H. Bonati, Henrik Gensicke, Stefan T. Engelter, Philippe A. Lyrer
Summary: Both once-daily and twice-daily direct oral anticoagulants show lower risk for recurrent ischemic stroke, major bleeding, and all-cause death compared to vitamin K antagonists in atrial fibrillation patients with recent stroke. There is no clear evidence that one dosing regimen of direct oral anticoagulants is more advantageous than the other.
EUROPEAN STROKE JOURNAL
(2022)
Article
Clinical Neurology
David J. Seiffge, Alexandros A. Polymeris, Zhe Kang Law, Kailash Krishnan, Annaelle Zietz, Sebastian Thilemann, David Werring, Rustam Al-Shahi Salman, Robert A. Dineen, Stefan T. Engelter, Philip M. Bath, Nikola Sprigg, Philippe Lyrer, Nils Peters
Summary: In this study, the type of intracerebral hemorrhage (ICH) did not show significant differences in terms of hematoma expansion (HE) or favorable outcome. Tranexamic acid was found to significantly reduce the risk of HE, regardless of the type of ICH, but was not associated with a favorable outcome. Patients with lobar CAA-ICH did not independently have an increased risk of HE, suggesting different dynamics compared to other types of ICH.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Roman F. Sztajzel, Stefan T. Engelter, Leo H. Bonati, Marie-Luise Mono, Agnieska Slezak, Rebekka Kurmann, Krassen Nedeltchev, Henrik Gensicke, Christopher Traenka, Ralf W. Baumgartner, Christophe Bonvin, Lorenz Hirt, Friedrich Medlin, Annika Burow, Georg Kaegi, Monika Kapauer, Jochen Vehoff, Karl O. Lovblad, Francois Curtin, Philippe A. Lyrer
Summary: This study aimed to determine the prognostic value of plaque surface echogenicity alone or combined with degree of stenosis for ischemic stroke or transitory ischemic attack (TIA). The results showed that a high proportion of low echogenicity on the surface of the plaque was strongly predictive of stroke or TIA occurrence, regardless of the degree of stenosis. These findings can help clinicians assess the risk and take preventive measures for adverse events in patients with carotid stenosis.
JOURNAL OF NEUROIMAGING
(2022)
Article
Multidisciplinary Sciences
Lea Beier, Shihai Lu, Lionel Riou Franca, Sabrina Marler, Gregory Y. H. Lip, Menno Huisman, Christine Teutsch, Jonathan L. Halperin, Kristina Zint, Hans-Christoph Diener, Laurie Baker, Chang-Sheng Ma, Miney Paquette, Dorothee B. Bartels, Sergio J. Dubner, Philippe Lyrer, Jochen Senges, Kenneth J. Rothman
Summary: The results of the third phase of the GLORIA-AF registry program show that OACs have become the standard treatment option for newly diagnosed AF patients, with most patients being prescribed a NOAC. However, there is still a significant proportion of patients who remain undertreated in certain regions.
Article
Clinical Neurology
Marta Kubacka, Annaelle Zietz, Sabine Schaedelin, Alexandros A. Polymeris, Lisa Hert, Johanna Lieb, Benjamin Wagner, David Seiffge, Christopher Traenka, Valerian L. Altersberger, Tolga Dittrich, Joachim Fladt, Urs Fisch, Sebastian Thilemann, Gian Marco De Marchis, Henrik Gensicke, Leo H. Bonati, Philippe Lyrer, Stefan T. Engelter, Nils Peters
Summary: Global cortical atrophy (GCA) is associated with the clinical prognosis of stroke patients with atrial fibrillation (AF) receiving oral anticoagulation.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Tolga D. Dittrich, Peter B. Sporns, Lilian F. Kriemler, Salome Rudin, Anh Nguyen, Annaelle Zietz, Alexandros A. Polymeris, Christopher Traenka, Sebastian Thilemann, Benjamin Wagner, Valerian L. Altersberger, Ines Piot, Filip Barinka, Martin Haensel, Henrik Gensicke, Stefan T. Engelter, Philippe A. Lyrer, Raoul Sutter, Christian H. Nickel, Mira Katan, Nils Peters, Lars Michels, Zsolt Kulcsar, Grzegorz M. Karwacki, Marco Pileggi, Carlo Cereda, Susanne Wegener, Leo H. Bonati, Urs Fischer, Marios Psychogios, Gian Marco De Marchis
Summary: This study examined the safety and efficacy outcomes of mechanical thrombectomy (MT) in patients with anterior circulation large vessel occlusions (LVO) who fulfilled or did not fulfill the DEFUSE-3 and DAWN trial inclusion criteria. The results showed that there were no significant differences in outcomes between patients who fulfilled the criteria and those who did not, suggesting the need for randomized trials with broader inclusion criteria for MT.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Tolga D. Dittrich, Peter B. Sporns, Lilian F. Kriemler, Salome Rudin, Anh Nguyen, Annaelle Zietz, Alexandros A. Polymeris, Christopher Tranka, Sebastian Thilemann, Benjamin Wagner, Valerian L. Altersberger, Ines Piot, Filip Barinka, Susanne Mueller, Martin Haensel, Henrik Gensicke, Stefan T. Engelter, Philippe A. Lyrer, Raoul Sutter, Christian H. Nickel, Mira Katan, Nils Peters, Zsolt Kulcsar, Grzegorz M. Karwacki, Marco Pileggi, Carlo Cereda, Susanne Wegener, Leo H. Bonati, Urs Fischer, Marios Psychogios, Gian Marco De Marchis
Summary: This study evaluated the efficacy and safety of mechanical thrombectomy (MT) in adult stroke patients with anterior circulation large vessel occlusion presenting in the late time window not fulfilling the DEFUSE-3 and DAWN inclusion criteria. The study found that MT was associated with higher odds of favorable functional outcomes without an increased risk of symptomatic intracranial hemorrhage. These findings support the use of more permissive inclusion criteria for MT in the late time window.
Article
Clinical Neurology
Tolga D. Dittrich, Mara Aujesky, Salome Rudin, Annaelle Zietz, Benjamin Wagner, Alexandros Polymeris, Valerian L. Altersberger, Tim Sinnecker, Henrik Gensicke, Stefan T. Engelter, Philippe Lyrer, Viviane Hess, Raoul Sutter, Christian H. Nickel, Leo H. Bonati, Urs Fischer, Marios Psychogios, Mira Katan, Gian Marco De Marchis
Summary: This study retrospectively included data from 2715 patients with acute stroke and found that 5.9% (161/2715) of patients had pulmonary lesions on CTA. Approximately one-third of these lesions (58/161) were suspicious for malignancy. Further investigation confirmed primary or secondary pulmonary malignancy in two-thirds of patients (12/16) and they received oncologic therapy.
EUROPEAN STROKE JOURNAL
(2023)
