Article
Nutrition & Dietetics
Fanny Petermann-Rocha, Stuart R. Gray, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales
Summary: The study revealed the joint association of different combinations of sarcopenia and frailty with adverse health outcomes, with the combination of sarcopenic/frail showing the strongest association with incidence and mortality of cardiovascular disease, respiratory disease, and cancer.
CLINICAL NUTRITION
(2021)
Article
Otorhinolaryngology
Khodayar Goshtasbi, Jack L. Birkenbeuel, Brandon M. Lehrich, Arash Abiri, Yarah M. Haidar, Tjoson Tjoa, Edward C. Kuan
Summary: Preoperative frailty has a significant impact on short-term outcomes following complex head and neck surgeries, including shorter operation time, longer length of stay, and higher rates of complications.Adjusting for age, sex, race, body mass index, smoking, and other factors, the modified frailty index can independently predict surgical outcomes and help in preoperative counseling and postoperative planning for complex head and neck surgery patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Surgery
Michelle A. Wan, James M. Clark, Miriam Nuno, David T. Cooke, Lisa M. Brown
Summary: This study demonstrates that the currently used frailty indices are not effective predictors of 30-day morbidity and mortality in patients undergoing high-risk surgery.
Article
Surgery
Kat L. Parmar, Jennifer Law, Ben Carter, Jonathan Hewitt, Jemma M. Boyle, Patrick Casey, Ishaan Maitra, Ian S. Farrell, Lyndsay Pearce, Susan J. Moug
Summary: This study on frailty in older adults undergoing emergency laparotomy found that 20% of older adults were frail, which was directly associated with increased risks of postoperative mortality and morbidity. Frailty scoring can aid decision-making and development of novel postoperative strategies.
Review
Clinical Neurology
Xinyi Wang, Rebecca J. St George, Quan Bai, Son N. Tran, Jane Alty
Summary: Essential Tremor (ET) is a common tremor disorder, but there is a high rate of misdiagnosis, especially in late-onset cases. Late-onset ET has been found to be associated with higher risk of cognitive impairment and dementia, higher mortality rate, faster progression, lack of family history, altered cortical electrical activity, prolonged pupillary responses, and reduced alcohol sensitivity compared to earlier-onset ET. The clinical manifestations of late-onset ET differ from earlier-onset ET, particularly with a higher risk of dementia and mortality. These findings are important for clinicians in selecting candidates for deep brain stimulation surgery and for advanced care planning.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Surgery
Vanessa P. Ho, Wyatt P. Bensken, David F. Warner, Jeffrey A. Claridge, Heena P. Santry, Jacinta C. Robenstine, Christopher W. Towe, Siran M. Koroukian
Summary: This study examines the associations between multimorbidity domain combinations and long-term mortality in older patients with emergency general surgery (EGS) conditions. The findings suggest that functional limitations may be the most important risk factor for long-term survival in these patients.
Article
Cardiac & Cardiovascular Systems
Joshua Solomon, Emmanuel Moss, Jean-Francois Morin, Yves Langlois, Renzo Cecere, Benoit de Varennes, Kevin Lachapelle, Nicolo Piazza, Giuseppe Martucci, Melissa Bendayan, Palina Piankova, Victoria Hayman, Marie-Claude Ouimet, Lawrence G. Rudski, Jonathan Afilalo
Summary: The study evaluated the use of the EFT in patients undergoing coronary artery bypass grafting procedures. It was found that the EFT could predict patient survival and had a significant impact on the survival rates. After adjustment, each incremental EFT point was associated with a higher risk of mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Chun-Qing Li, Hao Kong, Zhen-Zhen Xu, Jia-Hui Ma, Xue-Ying Li
Summary: This study compared the predictive abilities of two frailty indices (mFI and RAI-rev) in predicting life-threatening morbidity and mortality in older patients undergoing high-risk abdominal surgery. The results showed that both frailty indices displayed poor discrimination for postoperative life-threatening morbidity and mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Food Science & Technology
Yen-Hui Liao, Chien-Tai Hong, Tsai-Wei Huang
Summary: The study aimed to investigate the effects of Botulinum toxin (BoNT) on tremor and found that it significantly reduced hand tremor severity. Additionally, it did not cause significant muscular weakness adverse effects within 6 weeks of treatment.
Article
Gastroenterology & Hepatology
Lorena Puchades, Julia Herreras, Ana Ibanez, Erick Reyes, Gonzalo Crespo, Manuel Rodriguez-Peralvarez, Luis Cortes, Trinidad Serrano, Ainhoa Fernandez-Yunquera, Eva Montalva, Marina Berenguer
Summary: This study evaluated the predictive value of the liver frailty index in outpatients in the European liver transplant setting, showing that frailty does not impact pretransplant mortality and/or delisting, but is predictive of higher complication rates and longer post-transplant length of stay. The findings highlight the importance of measuring physical frailty systematically during clinic visits and support further research on rehabilitation strategies in liver transplant settings with short waiting times.
Article
Neuroimaging
Patrick Bedard, Pattamon Panyakaew, Hyun-Joo Cho, Mark Hallett, Silvina G. Horovitz
Summary: This study aimed to understand the differential pathophysiology of essential tremor and dystonic tremor. The results showed altered functional connectivity in the cerebellum for essential tremor patients, higher fractional anisotropy in the middle cerebellar peduncle for dystonic tremor patients, and reduced mean diffusivity in the cerebellum for both tremor groups. The findings suggest that the cerebellum is affected differently in both essential tremor and dystonic tremor.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Luca Angelini, Giulia Paparella, Alessandro De Biase, Annalisa Maraone, Matteo Panfili, Isabella Berardelli, Antonio Cannavacciuolo, Antonella Di Vita, Roberta Margiotta, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
Summary: This study investigated the progression of Essential Tremor (ET) manifestations through clinical and neurophysiological evaluation. The results showed that ET progression is characterized by the spread of tremor in multiple body segments and the emergence of soft signs. Female sex, absence of family history, and rest tremor at baseline were identified as predictive factors of worse disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno
Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Christian Habib Ayoub, Elia Abou Chawareb, Abdallah El Kasti, Eliane Alhalabi, Jose M. El-Asmar, Anthony Abou Mrad, Albert El Hajj
Summary: The purpose of the study was to assess the ability of the 5-item frailty index (5-IFi) score to predict 30-day morbidity and mortality post-radical nephrectomy. Using the ACS-NSQIP database, patients who underwent RN from 2011 to 2020 were selected. The 5-IFi score was found to be an independent predictor of prolonged length of stay, morbidity, and mortality after RN, and can be used for preoperative risk assessment and patient counseling.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Surgery
Pau Forte-Genesca, Eduard Casajuana Urgell, Carles Diaz-Duran, Lorena Romero-Montana, Ezequiel Paredes-Marinas, Albert Clara-Velasco
Summary: This study examined the relationship between multiple CT-derived measurements of sarcopenia and the 5-year survival after AAA repair. The results showed that these measurements were significantly associated with survival, but their inclusion did not improve survival prediction accuracy.
WORLD JOURNAL OF SURGERY
(2023)
Review
Clinical Neurology
Devlina Roy, Ritwik Ghosh, Souvik Dubey, Mahua Jana Dubey, Julian Benito-Leon, Biman Kanti Ray
Summary: Neurological and neuropsychiatric manifestations of COVID-19 are diverse, involving both central and peripheral nervous systems. Most psychological effects stem from pandemic-related regulatory, socioeconomic, and psychosocial changes.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2021)
Review
Geriatrics & Gerontology
Felix Bermejo-Pareja, Israel Contador, Teodoro del Ser, Javier Olazaran, Sara Llamas-Velasco, Saturio Vega, Julian Benito-Leon
Summary: MCI is the most commonly mentioned predementia entity, recognized as a harbinger of dementia caused by various etiologies, mainly MCI due to Alzheimer's disease. The operational definition of MCI has shortcomings, as does the recent miNCD construct. Current data suggest that miNCD is a stricter predementia condition with lower prevalence than MCI, less sensitivity to cognitive decline, and possibly a higher conversion rate to dementia.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Immunology
Ritwik Ghosh, Kaustav De, Devlina Roy, Arpan Mandal, Subrata Biswas, Subhrajyoti Biswas, Swagatam Sengupta, Dinabandhu Naga, Mrinalkanti Ghosh, Julian Benito-Leon
Summary: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease characterized by the presence of pathogenic antibodies to aquaporin-4 (AQP-4) water channels. Various viral infections, including COVID-19, have been suggested to trigger NMOSD. However, while cases of spinal cord involvement following SARS-CoV-2 infection have been reported, AQP-4-antibody-seropositive NMOSD following COVID-19 is still rare.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Behavioral Sciences
Aida Arroyo, Jose A. Perianez, Marcos Rios-Lago, Genny Lubrini, Jorge Andreo, Julian Benito-Leon, Elan D. Louis, Juan Pablo Romero
Summary: The study found that the slowing of information processing in PD was mainly associated with impaired processing speed of the motor and perceptual-alertness components analyzed. These results may help in designing new neurorehabilitation strategies that focus on improving perceptual and alertness mechanisms.
BRAIN AND BEHAVIOR
(2021)
Letter
Clinical Neurology
Angela Domingo-Santos, Andres Labiano-Fontcubert, Yolanda Aladro-Benito, M. Luisa Martinez-Gines, Lucia Ayuso-Peralta, Veronica Puertas-Martin, Marta Cerezo-Garcia, Yolanda Higueras-Hernandez, Virginia Mato-Abad, Juan Alvarez-Linera, Juan Antonio Hernandez-Tamames, Julian Benito-Leon
Summary: In a study of patients with radiologically isolated syndrome (RIS), it was found that 35.3% of patients exhibited cognitive impairment, with lower brain and gray matter volumes compared to healthy controls. After a median follow-up period of 4.5 years, the cognitively impaired RIS subgroup showed a higher conversion rate to multiple sclerosis (MS), suggesting that cognitive impairment may be an independent risk factor for conversion to MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Sonia Mayo, Irene Gomez-Manjon, Fco. Javier Fernandez-Martinez, Ana Camacho, Francisco Martinez, Julian Benito-Leon
Summary: Based on a review of patients diagnosed with EMA (or EMA-like phenotype) with a genetic diagnosis, four genes could potentially be associated with this syndrome, while three other genes require further study for their possible connection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Julian Benito-Leon, Ma Dolores del Castillo, Alberto Estirado, Ritwik Ghosh, Souvik Dubey, J. Ignacio Serrano
Summary: A few standard laboratory tests can effectively differentiate severity subgroups among patients with COVID-19.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Clinical Neurology
Ritwik Ghosh, Subhrajyoti Biswas, Arnab Mandal, Kaustav De, Srijit Bandyopadhyay, Sona Singh Sardar, Arpan Mandal, Julian Benito-Leon
Summary: This case report describes a 14-year-old Indian girl with scrub typhus-associated abducens nerve palsy, who did not exhibit fever and the classic dermatological manifestation of the disease. The patient responded well to doxycycline therapy after common infectious, autoimmune, and neoplastic causes were excluded.
NEURO-OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Subhrajyoti Biswas, Ritwik Ghosh, Dipayan Roy, Adrija Ray, Kaustav De, Subrata Biswas, Dinabandhu Naga, Julian Benito-Leon
Summary: Scrub typhus, a mite-born rickettsial zoonosis, can lead to a variety of clinical manifestations including limbic encephalitis. This case report highlights the successful diagnosis and treatment of scrub typhus associated encephalitis in a previously healthy young Indian woman.
Review
Clinical Neurology
Subhrajyoti Biswas, Ritwik Ghosh, Arpan Mandal, Alak Pandit, Dipayan Roy, Samya Sengupta, Kaustav De, Bikash Chandra Swaika, Julian Benito-Leon
Summary: This case report describes a patient with autonomic dysfunction preceding the onset of Miller Fisher syndrome post COVID-19 infection. The patient, who tested positive for anti-ganglioside antibodies, showed a good response to treatment with intravenous immunoglobulin. The article also discusses the potential pathogenic mechanisms of COVID-19 induced Miller Fisher syndrome and provides a review of reported cases.
Article
Chemistry, Analytical
Cecilia Garcia Cena, Mariana Campos Costa, Roque Saltaren Pazmino, Cristina Peixoto Santos, David Gomez-Andres, Julian Benito-Leon
Summary: There is evidence of eye movement alterations in neurological diseases, and this study is the first to describe potential eye movement alterations in post-COVID-19 condition using video-oculography. The study found that patients with the post-COVID-19 condition had eye movement alterations, mainly in centripetal latency in visually guided saccades, success rate in memory-guided saccades, latency in antisaccades, and its standard deviation, suggesting the involvement of frontoparietal networks. Further research is needed to understand the functional consequences of these eye movement alterations.
Review
Biochemistry & Molecular Biology
Sonia Mayo, Irene Gomez-Manjon, Francisco Javier Fernandez-Martinez, Ana Camacho, Francisco Martinez, Julian Benito-Leon
Summary: Epilepsy is a common neurological disorder with a complex genetic basis. Although many genes associated with epilepsy have been identified, there are still cases where the genetic cause is unknown. Recent research has shown that somatic mutations specific to brain tissue may play a role in the phenotypic spectrum of epilepsy. These mutations cannot be detected in blood cells, but can be identified in cell-free DNA. Further studies are needed to explore this mechanism and its potential for diagnosing refractory epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dipayan Roy, Anupama Modi, Ritwik Ghosh, Raghumoy Ghosh, Julian Benito-Leon
Summary: This study aimed to investigate the gene expression pattern and regulatory network in the visceral adipose tissue of obese pediatric individuals. The results identified pathways and diseases related to obesity and its associated complications, emphasizing the importance of the TGF-beta signaling pathway, immune system, and adipocytic apoptotic pathway in pediatric obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Cecilia E. Garcia Cena, David Gomez-Andres, Irene Pulido-Valdeolivas, Victoria Galan Sanchez-Seco, Angela Domingo-Santos, Sara Moreno-Garcia, Julian Benito-Leon
Summary: This study aimed to assess the cognitive status of patients with relapsing-remitting multiple sclerosis (MS) by measuring eye movement. The results showed significant alterations in eye movement behavior among MS patients, but without a common pattern. This may be due to the heterogeneous distribution of white matter involvement in MS, and further research is needed to determine the cause of these changes.
Article
Oncology
Souvik Dubey, Ritwik Ghosh, Subhankar Chatterjee, Mahua Jana Dubey, Samya Sengupta, Subham Chatterjee, Biman Kanti Ray, Pedro J. Modrego, Julian Benito-Leon
Summary: Brain tumors have long been considered a prevalent cause of potentially reversible cognitive impairment, with patterns of impairment depending on location, lateralization, classification, and treatment effects. Detailed eye movement and motor examinations are crucial for diagnosing cognitive impairment due to brain tumors and ruling out other coexisting etiologies.
CASE REPORTS IN ONCOLOGY
(2021)