Article
Clinical Neurology
Giacomo Koch, Elias Paolo Casula, Sonia Bonni, Ilaria Borghi, Martina Assogna, Marilena Minei, Maria Concetta Pellicciari, Caterina Motta, Alessia D'Acunto, Francesco Porrazzini, Michele Maiella, Clarissa Ferrari, Carlo Caltagirone, Emiliano Santarnecchi, Marco Bozzali, Alessandro Martorana
Summary: In a 24-week trial, repetitive transcranial magnetic stimulation of the precuneus was found to slow down cognitive and functional decline in patients with Alzheimer's disease. The study suggests that targeting the default mode network could be a novel therapeutic approach for Alzheimer's disease patients.
Article
Clinical Neurology
Anna Rosenberg, Alina Solomon, Hilkka Soininen, Pieter Jelle Visser, Kaj Blennow, Tobias Hartmann, Miia Kivipelto
Summary: The study explored the utility of IWG-1 criteria in recruiting individuals for AD clinical trials and found that the criteria reliably identified individuals with AD pathology. More pragmatic and easily applicable selection criteria may be preferred in certain situations.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Geriatrics & Gerontology
Yotam Lavy, Tzvi Dwolatzky, Zeev Kaplan, Jonathan Guez, Doron Todder
Summary: The study found that using an EEG-based neurofeedback system can significantly improve memory performance in patients with mild cognitive impairment (MCI), with this improvement lasting for at least one month.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Fang Yu, David M. Vock, Lin Zhang, Dereck Salisbury, Nathaniel W. Nelson, Lisa S. Chow, Glenn Smith, Terry R. Barclay, Maurice Dysken, Jean F. Wyman
Summary: The study found that for older adults with mild-to-moderate Alzheimer's disease, exercise may help reduce the decline in global cognition. However, aerobic exercise did not show superior cognitive effects compared to stretching, possibly due to the lack of power in the pilot trial.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Chemistry, Medicinal
Omid Reza Tamtaji, Reza Heidari-soureshjani, Zatollah Asemi, Ebrahim Kouchaki
Summary: The study aimed to investigate the effects of spirulina intake on cognitive function and metabolic status in patients with Alzheimer's disease (AD). A randomized, double-blind, controlled clinical trial was conducted involving 60 AD patients. The results showed that spirulina intake for 12 weeks significantly improved cognitive function and glucose homeostasis, while reducing high-sensitivity C-reactive protein levels. These findings suggest that spirulina may have beneficial effects in AD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Health Care Sciences & Services
Shirlene Vianna Moreira, Francis Ricardo dos Reis Justi, Carlos Falcao de Azevedo Gomes, Marcos Moreira
Summary: This study suggests that a music therapy intervention can be promising for improving episodic memory in older adults, especially those with dementia.
Article
Clinical Neurology
Bruno Dubois, Jesus Lopez-Arrieta, Stanley Lipschitz, Doskas Triantafyllos, Luiza Spiru, Svitlana Moroz, Olena Venger, Patrick Vermersch, Alain Moussy, Colin D. D. Mansfield, Olivier Hermine, Magda Tsolaki
Summary: The study found that the tyrosine kinase inhibitor masitinib, when administered orally, can be beneficial as an adjunct treatment for mild-to-moderate Alzheimer's disease. It showed significant improvement in cognitive and functional abilities, with side effects consistent with known information. Further research is ongoing to validate these results.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Michael K. Scullin, Winston E. Jones, Richard Phenis, Samantha Beevers, Sabra Rosen, Kara Dinh, Andrew Kiselica, Francis J. Keefe, Jared F. Benge
Summary: This study found that older adults with cognitive disorders can benefit from smartphone-based memory strategies, leading to improvements in prospective memory functioning and independence. Participants who used the digital recorder or reminder app more frequently showed better prospective memory performance and greater improvements in daily living activities.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Neurosciences
Patricio Solis-Urra, Cristina Molina-Hidalgo, Yolanda Garcia-Rivero, Claudia Costa-Rodriguez, Jose Mora-Gonzalez, Beatriz Fernandez-Gamez, Marcos Olvera-Rojas, Andrea Coca-Pulido, Angel Toval, Dario Bellon, Alessandro Sclafani, Isabel Martin-Fuentes, Eva Maria Trivino-Ibanez, Carlos de Teresa, Haiqing Huang, George Grove, Charles H. Hillman, Arthur F. Kramer, Andres Catena, Francisco B. Ortega, Manuel Gomez-Rio, Kirk I. Erickson, Irene Esteban-Cornejo
Summary: Alzheimer's disease is the leading cause of dementia globally and has significant socio-economic impact. Physical exercise has been proposed as an effective non-pharmaceutical intervention to improve cognitive function and delay dementia progression. This randomized controlled trial aims to investigate the effects of a 24-week resistance exercise program on executive function and related brain and molecular biomarkers in cognitively normal older adults, aged 65-80 years. The findings from this study will contribute to a better understanding of the mechanisms involved in exercise-mediated cognitive improvements in aging populations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Aladdin H. Shadyab, Andrea Z. LaCroix, Howard H. Feldman, Christopher H. van Dyck, Ozioma C. Okonkwo, Steven P. Tam, J. Kaci Fairchild, Kathleen A. Welsh-Bohmer, Genevieve Matthews, Daniel Bennett, Alexandre A. Shadyab, Kimberly A. Schafer, Rosemary H. Morrison, Sean A. Kipperman, Jennifer Mason, Donna Tan, Ronald G. Thomas, Carl W. Cotman, Laura D. Baker
Summary: Effective recruitment strategies for older adults with MCI into nonpharmacological intervention trials are lacking. However, mass mailings of infographic materials significantly increased recruitment rates in this 18-month exercise trial, accounting for 52% of randomized participants. Other sources included memory clinic rosters, electronic health records, and national/local registries.
ALZHEIMERS & DEMENTIA
(2021)
Article
Chemistry, Medicinal
Elaheh Foroumandi, Roghayeh Javan, Leili Moayed, Hossein Fahimi, Fereshteh Kheirabadi, Mahboubeh Neamatshahi, Fazeleh Shogofteh, Azam Zarghi
Summary: This study investigated the effects of fenugreek seed extract on memory, depression, quality of life, blood pressure, and serum malondialdehyde (MDA) and total antioxidant capacity (TAC) levels in adult AD patients. The results showed that fenugreek seed extract supplementation for 4 months significantly increased TAC levels and reduced MDA levels. Additionally, memory, quality of life, depression, systolic blood pressure, and diastolic blood pressure improved in the intervention group compared to baseline.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Julia Maria Falkenreck, Michelle Celine Kunkler, Anja Ophey, Hannah Weigert, Andrea Friese, Petra Jahr, Gereon Nelles, Elke Kalbe, M. Cristina Polidori
Summary: This study compared the short-term effects of multicomponent cognitive training with general health counseling on cognitive abilities and health-related quality of life in healthy adults. The results showed that multicomponent cognitive training did not have a significant impact on overall cognition, but there were improvements in some cognitive subtests and quality of life measures that were clinically meaningful.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Xingqi Wu, Gong-Jun Ji, Zhi Geng, Lu Wang, Yibing Yan, Yue Wu, Guixian Xiao, Liying Gao, Qiang Wei, Shanshan Zhou, Ling Wei, Yanghua Tian, Kai Wang
Summary: Accelerated intermittent theta-burst stimulation (iTBS) in the left dorsolateral prefrontal cortex (DLPFC) has been shown to enhance associative memory (AM) in patients with Alzheimer's disease (AD). Results indicate that patients in the active group showed significant improvements in AM at week 2 and week 10, particularly those with higher baseline Mini-Mental State Examination (MMSE) scores.
Article
Clinical Neurology
Glen Wunderlich, Zuzana Blahova, Miguel Garcia, Frank Jessen
Summary: This study assessed the efficacy and safety of BI 425809 in treating cognitive impairment associated with probable Alzheimer's disease dementia. The results showed that BI 425809 did not lead to clinically meaningful changes from baseline in patients with mild-to-moderate probable Alzheimer's disease dementia.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Kay Deckers, Sebastian Kohler, Tiia Ngandu, Riitta Antikainen, Tiina Laatikainen, Hilkka Soininen, Timo Strandberg, Frans Verhey, Miia Kivipelto, Alina Solomon
Summary: Individuals in early dementia prevention trials may benefit differently from interventions based on their initial risk levels, as measured by the LIBRA score. The FINGER intervention was effective in reducing LIBRA scores over time, regardless of baseline demographics or cognition. LIBRA may serve as a useful surrogate/intermediate endpoint and surveillance tool to monitor intervention success during trial execution.
ALZHEIMERS & DEMENTIA
(2021)