期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 75, 期 -, 页码 195-202出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.01.006
关键词
Selenopheno[2,3-d]pyrimidines; Triazolothiadiazoles; Synthesis; Antimicrobial activities; Antioxidant properties; Molecular docking
资金
- UGC-BSR (RFSMS)
A series of 1,2,4-(triazolo[3,4-b][1,3,4]thiadiazol-6-ypselenopheno[2,3-d]pyrimidines (10a-j) were synthesized with various substituted anilines and benzoic acids. Structures of newly synthesized compounds were established by IR, H-1 & C-13 NMR and LC-MS spectral data. The antioxidant activity of the synthesized compounds was evaluated by DPPH, NO and H2O2 radical scavenging methods. The newly synthesized compounds were evaluated for their antimicrobial activity against Gram +ve and Gram -ve bacteria and antifungal activity by well diffusion method. Compounds 10d, 10h and 10i showed promising antioxidant, antibacterial as well as antifungal activity and these were found to be the most potent activity molecules when compared with that of standard drugs. Molecules docking studies have been performed on Staphylococcus aureus (SA) of Gram +ve bacteria. (C) 2014 Elsevier Masson SAS. All rights reserved.
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