期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 74, 期 -, 页码 225-233出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.12.061
关键词
Coumarin; Heterocycles; Iodine; Anticancer; Anti-mycobacterial; SAR
资金
- Vision Group of Science and Technology (VGST), Department of IT, BT, Science & Technology, Government of Karnataka [VGST/P-15/K-FIST Level-1/2010-11/744]
A series of new iodinated-4-aryloxymethylcoumarins 6, 8 and 10 have been obtained from the reaction of various 4-bromomethylcoumarins 4 with 2-iodophenol 5, 3-iodophenol 7 and 4-iodophenol 9 respectively. All the title compounds were screened for anticancer activity against two cancer cell lines (MDA-MB human adenocarcinoma mammary gland and A-549 human lung carcinoma) and two mycobacterial strains (Mycobacterium tuberculosis H-37 RV and Mycobacterium phlei). The SAR results indicate that nine compounds are potent, among these 10h and 10i having chlorine are most effective. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure activity relationship for this new class of iodinated-4-aryloxymethyl-coumarins. (C) 2014 Elsevier Masson SAS. All rights reserved.
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