期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 80, 期 -, 页码 316-324出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.04.070
关键词
Ruthenium(II) complexes; Microwave-assisted synthesis; Apoptosis induction; c-myc G4 DNA
资金
- Science and Technology Item Foundation of Guangzhou [2013J4100072]
- Young Teachers Foundation of Guangdong Pharmaceutical University
Two ruthenium(II) complexes, [Ru(L)(2)(p-tFMPIP)](ClO4)(2) (L = bpy, 1; phen, 2; p-tFMPIP = 2-(4-(tri-fluoromethyphenyl)-1H-imidazo[4,5f][1,10] phenanthroline)), were prepared by microwave-assisted synthesis technology. The inhibitory activity evaluated by MIT assay shown that 2 can inhibit the growth of MDA-MB-231 cells with inhibitory activity (IC50) of 16.3 mu M which was related to the induction of apoptosis. Besides, 2 exhibit low toxicity against normal HAcat cells. The inhibitory growth activity of both complexes related to the induction of apoptosis was also confirmed. Furthermore, the studies on the interaction of both complexes with c-myc G4 DNA shown that 1 and 2 can stabilize the conformation of c-myc G4 DNA in groove binding mode, which has been rational explained by using DFT theoretical calculation methods. In a word, this type of ruthenium(II) complexes can act as potential apoptosis inducers with low toxicity in clinic by stabilizing c-myc G4 DNA. (C) 2014 Elsevier Masson SAS. All rights reserved.
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