期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 81, 期 -, 页码 499-509出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.04.085
关键词
Indole-chalcone fibrates; Antidyslipidemic activity; Triton model; LPL activity; Antioxidant activity
资金
- CSIR-CDRI Network project: Towards holistic understanding of complex diseases: Unraveling the threads of complex disease (THUNDER) Project [BSC0102]
- CSIR, New Delhi, India
A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents. (C) 2014 Elsevier Masson SAS. All rights reserved.
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