期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 -, 页码 420-431出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2012.08.001
关键词
Ruthenium complexes; Hydrazones; DNA interaction; Protein binding; Radical scavenging; Cytotoxicity
资金
- Department of Science and Technology (DST), Government of India, New Delhi
Bivalent, ruthenium organometallics containing hydrazone ligands with the composition [RuH(CO)(PPh3)(2)(L1-3)] (4-6) have been synthesised from the reactions of [RuH2(CO)(PPh3)(3)] and benzoic acid pyridine-2-ylmethylene-hydrazide (HL1) (1) /benzoic acid (1-pyridin-2-yl-ethylidene)-hydrazide (HL2) (2)/benzoic acid (phenyl-pyridin-2-yl-methylene)-hydrazide (HL3) (3) and characterised by various physico-chemical techniques. The X-ray crystal structure of one of the above complexes, [RuH(CO)(PPh3)(2)(L-3)] (6) demonstrated a distorted octahedral coordination geometry around the metal centre. Results of our investigation on the effect of substitution (H or CH3 or C6H5) at the azomethine carbon of coordinated hydrazone in these ruthenium chelates on the potential binding with DNA/BSA, free radical scavenging and cytotoxicity is presented. (C) 2012 Elsevier Masson SAS. All rights reserved.
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