Novel metal based anti-tuberculosis agent: Synthesis, characterization, catalytic and pharmacological activities of copper complexes

Copper complexes of molecular formulae, [CuL1(OAc)], [CuL2(H2O)], [CuL3(H2O)], [CuL4(H2O)], [CuL5(H2O)] where L-1-L-5 represents Schiff base ligands by the condensation of 3-hydroxyflavone with 4-aminoantipyrine (L-1)/o-aminophenol (L-2)/o-aminobenzoic acid (L-3)/o-aminothiazole (L-4)/thio-semicarbazide (L-5)], have been prepared. They were characterized using analytical and spectral techniques. The DNA binding properties of copper complexes were studied using electronic absorption spectra and viscosity measurements. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. Furthermore, the copper complexes have been found to promote pUC18 DNA cleavage in the presence of oxidant. Anti-tuberculosis activity was also performed. (C) 2012 Elsevier Masson SAS. All rights reserved.